Title:Vitamin A: Modulating Effect on Breast Carcinogenesis
Volume: 17
Issue: 2
Author(s): Thaís R. Nogueira*, Victor A. de Oliveira, Irislene C. Pereira, Cecília Maria Resende G. de Carvalho, Gilmara Péres-Rodrigues, Maria do Carmo de Carvalho e Martins, Karoline de Macedo G. Frota, Adriana de Azevedo Paiva and Betânia de Jesus e Silva de Almendra Freitas
Affiliation:
- Department of Nutrition, Federal University of Piaui, UFPI, Piaui State, Teresina,Brazil
Keywords:
Breast cancer, diet, inflammation, isoforms, retinol, tumorigenesis.
Abstract: Breast cancer has a multifactorial etiology and, among the main causal factors, the dietary
profile stands out, mainly the components of the pro-inflammatory diet and their interaction with genetic
characteristics. In this sense, deciphering the molecular networks involved in the proliferation
of cancer cells in breast tissue can determine ways of action of organic compounds that modulate the
pathogenesis of cancer, such as vitamin A and analogs, as well as their possible mechanisms of modulation
of breast tumorigenesis. This is a review study conducted according to the guidelines of the
Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and by consulting
the PubMed and Web of Science databases including articles, published in Portuguese, English and
Spanish, in the last five years. 126 articles were obtained, of which 13 were selected for full analysis
and only 6 were included in the study for meeting the eligibility criteria. The results of the compiled
studies demonstrate the role of some retinol-binding proteins in metabolism, as well as in differentiation,
cell proliferation and inflammation. Although controversial, the results point to the use of these
proteins as possible prognostic markers. The need for further studies in humans is also emphasized in
order to assess the main effects of vitamin isoforms on tumor activity.