Title:Berberine Administration in Treatment of Colitis: A Review
Volume: 21
Issue: 13
关键词:
抗氧化,抗炎,小檗碱,结肠炎,炎症性肠病,冬青叶小檗
摘要: Berberine (Brb) is one of the well-known naturally occurring compounds exclusively found
in Berberis vulgaris and other members of this family, such as Berberis aristata, Berberis aroatica,
and Berberis aquifolium. This plant-derived natural compound has a variety of therapeutic impacts,
including anti-oxidant, anti-inflammatory, anti-diabetic, and anti-tumor. Multiple studies have demonstrated
that Brb has great anti-inflammatory activity and is capable of reducing the levels of proinflammatory
cytokines, while it enhances the concentrations of anti-inflammatory cytokines, making
it suitable for the treatment of inflammatory disorders. Colitis is an inflammatory bowel disease with
chronic nature. Several factors are involved in the development of colitis and it appears that inflammation
and oxidative stress are the most important ones. With respect to the anti-inflammatory and antioxidant
effects of Brb, its administration seems to be beneficial in the treatment of colitis. In the present
review, the protective effects of Brb in colitis treatment and its impact on molecular pathways are
discussed.