Title:Protective Effects of Polydatin Against Dementia-Related Disorders
Volume: 19
Issue: 2
Author(s): Kim San Tang*
Affiliation:
- School of Pharmacy, Monash University Malaysia, Bandar Sunway, Selangor,Malaysia
Abstract: Dementia is a collection of symptoms affecting a person’s cognition. Dementia is
debilitating, and therefore, finding an effective treatment is of utmost importance. Resveratrol,
which exhibits neuroprotective effects, has low bioavailability. However, its glucoside polydatin is
more bioavailable. Here, the evidence that supports the protective role of polydatin against dementia-
related diseases such as Alzheimer’s disease, vascular dementia, alcohol-related dementia, and
Lewy body dementias is presented. The beneficial effects of polydatin from a mechanistic perspective
are specifically emphasized in this review. Future directions in this area of research are also
discussed.