Abstract
Background: Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early and later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medicinal, clinical and pharmaceutical research. Voltammetry is one of the most commonly used electroanalytical methods. This review aims to gather and discuss studies of voltammetric methods used in determination of dopamine agonists.
Methods: This review includes the use of various voltammetric methods for determination studies of dopamine agonists from pharmaceutical dosage forms and biological samples. These studies were examined in terms of used voltammetric method or methods, working electrode, buffer, pH and validation parameters.
Results: Cabergoline, pramipexole, and ropinirole have more studies, while bromocriptine and apomorphine have fewer studies in the literature. Differential pulse voltammetry and square wave voltammetry methods were the most applied methods for the determination of dopamine agonist drugs from pharmaceuticals and biological samples. But, stripping, cyclic and linear sweep voltammetry methods are less applied methods. In these studies, a lot of modified electrodes were developed and used to analyse dopamine agonists.
Conclusion: The voltammetric methods provide the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations without the necessity for the sample pre-treatment or time consuming extraction steps. Also, the modified electrodes and validated voltammetric methods provide good stability, repeatability, reproducibility and high recovery for the analysis of the analyte.
Keywords: Apomorphine, bromocriptine, cabergoline, determination, dopamine agonists, pramipexole, ropinirole, validation, voltammetric methods.
Current Analytical Chemistry
Title:A Review of Voltammetric Methods for Determination of Dopamine Agonists
Volume: 17 Issue: 8
Author(s): Fatma Ağın*
Affiliation:
- Department of Analytical Chemistry, Faculty of Pharmacy, Karadeniz Technical University, Trabzon,Turkey
Keywords: Apomorphine, bromocriptine, cabergoline, determination, dopamine agonists, pramipexole, ropinirole, validation, voltammetric methods.
Abstract:
Background: Dopamine agonists are useful drugs for the management of patients with Parkinson's disease in the early and later stages of the disease. Parkinson's disease is a progressive neurodegenerative disease that primarily affects dopamine-producing nerve cells in the brain. They bind to dopamine receptors in nerve cells that regulate body movement and motor function. Electroanalytical methods are used in medicinal, clinical and pharmaceutical research. Voltammetry is one of the most commonly used electroanalytical methods. This review aims to gather and discuss studies of voltammetric methods used in determination of dopamine agonists.
Methods: This review includes the use of various voltammetric methods for determination studies of dopamine agonists from pharmaceutical dosage forms and biological samples. These studies were examined in terms of used voltammetric method or methods, working electrode, buffer, pH and validation parameters.
Results: Cabergoline, pramipexole, and ropinirole have more studies, while bromocriptine and apomorphine have fewer studies in the literature. Differential pulse voltammetry and square wave voltammetry methods were the most applied methods for the determination of dopamine agonist drugs from pharmaceuticals and biological samples. But, stripping, cyclic and linear sweep voltammetry methods are less applied methods. In these studies, a lot of modified electrodes were developed and used to analyse dopamine agonists.
Conclusion: The voltammetric methods provide the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations without the necessity for the sample pre-treatment or time consuming extraction steps. Also, the modified electrodes and validated voltammetric methods provide good stability, repeatability, reproducibility and high recovery for the analysis of the analyte.
Export Options
About this article
Cite this article as:
Ağın Fatma *, A Review of Voltammetric Methods for Determination of Dopamine Agonists, Current Analytical Chemistry 2021; 17 (8) . https://dx.doi.org/10.2174/1573411016999200526130915
DOI https://dx.doi.org/10.2174/1573411016999200526130915 |
Print ISSN 1573-4110 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6727 |
Call for Papers in Thematic Issues
Advancements in biomedicine, corrosion inhibition/monitoring, and lubrication of carbon dots
Carbon dots, a class of carbon-based nanomaterials, have garnered substantial interest in various scientific and engineering fields due to their unique properties, including excellent optical properties, outstanding biocompatibility, easy preparation, good dispersity, ultrasmall size, low toxicity and environmental friendliness. This special issue of Current Analytical Chemistry aims to showcase cutting-edge ...read more
Advances in Microfluidic and Sensing Technologies of Biofluids.
Detection of biological fluids is an important means to assess human health and diagnose diseases. Currently, research on blood is relatively mature and widely applied in the medical field. With the development and advancement of microfluidic technology and novel detection methods, attention has turned to human physiological fluids such as ...read more
Analytical methods for environmental and food analysis
In recent years, the study of the chemical composition of food and the environment depends on analytical methods in order to acquire information about the chemical composition, processing, quality control and contamination of soil, water, air, plants and foods, aspects very important for food safety and environmental quality control. There ...read more
Applications of artificial intelligence in chemical analysis
Artificial intelligence (AI) has demonstrated its versatility in almost all scientific fields, especially analytical chemistry, which is leading the way in the integration of AI. According to Chemical Abstract Services, one of the major disciplines contributing to AI-related publications and patents is analytical chemistry. That?s because techniques such as deep ...read more
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Genetics of Atherosclerosis in Murine Models
Current Drug Targets Red Wine Consumption and Prevention of Atherosclerosis: An In Vitro Model Using Human Peripheral Blood Mononuclear Cells
Current Pharmaceutical Design Pharmacogenetics of the Antiplatelet Effect of Aspirin
Current Pharmaceutical Design Apolipoprotein B Antisense Inhibition -Update on Mipomersen
Current Pharmaceutical Design Coal Mine Dust Lung Disease: The Silent Coal Mining Disaster
Current Respiratory Medicine Reviews Pharmacogenomic Considerations of the Insertion / Deletion Gene Polymorphism of the Angiotensin I-Converting Enzyme and Coronary Artery Disease
Current Vascular Pharmacology Pharmacologic Role of Vitamin D Natural Products
Current Vascular Pharmacology Sleep-Related Disorders, Diabetes and Obesity: Understanding the Facts
Current Respiratory Medicine Reviews Cytokine Gene Variants as Predictors of Type 2 Diabetes Mellitus
Current Diabetes Reviews Supplementation, Optimal Status, and Analytical Determination of Vitamin D: Where are we Standing in 2012?
Anti-Cancer Agents in Medicinal Chemistry Newly Diagnosed Dementia and Increased Risk of Hemorrhagic Stroke: A Nationwide Population-based Study
Current Alzheimer Research Bile Acid Reabsorption Inhibitors (BARI): Novel Hypolipidemic Drugs
Current Medicinal Chemistry Outline of Proteins and Signaling Pathways Involved in Heart Failure
Current Protein & Peptide Science Peripartum Cardiomyopathy: Moving Towards a More Central Role of Genetics
Current Cardiology Reviews Study of the Interaction Between Graphene Oxide and Surface-confined Biomolecules to Develop New Kind of Biosensors
Current Nanoscience The Endocannabinoid System: A Promising Target for the Management of Type 2 Diabetes
Current Protein & Peptide Science Neopterin as a Marker for Immune System Activation
Current Drug Metabolism Inverse Regulation of MMP-9 and MMP-2 in Long-Term Follow-up After Acute Coronary Syndrome: Lack of Correlation with Platelet and Endothelial Cell Activation Markers
Vascular Disease Prevention (Discontinued) The Role of Amino Acids in the Modulation of Cardiac Metabolism During Ischemia and Heart Failure
Current Pharmaceutical Design Clinical Trials: How to Assess Confounding and Why So
Current Clinical Pharmacology