Title:BK Polyoma Virus Nephropathy in an Immunocompromised Host
Volume: 2
Author(s): Faraz Khan*, Maroun El Khoury, Fahad Kouli and Aaron Han
Affiliation:
- Department of Oncology, American Hospital Dubai, Dubai,United Arab Emirates
Keywords:
PTLD, Burkitt's Lymphoma, BK polyomavirus nephropathy, Lymphoproliferative disorders, Immunosuppression, Chemoimmunotherapy.
Abstract:
Background:
Post-transplant Lymphoproliferative Disorders (PTLD) are a well known late complication after solid organ transplantation, including renal
transplant. Among others, graft failure due to reactivation of BK polyomavirus in the grafted kidney is also a well-recognized complication but
tends to present early in the first several months after transplant.
Case:
Here we present the case of PTLD Burkitt's Lymphoma (BL-PTLD) in a renal transplant patient who was successfully treated with multiagent
chemo-immunotherapy but later developed BK polyomavirus nephropathy (BKVN) with graft failure only after completion of her systemic
therapy for lymphoma and 7 years after the transplant. Relevant literature is reviewed.
Conclusion:
In this case, reactivation and progression of BKVN were most likely associated with immunosuppression from chemo-immunotherapy for her
BL–PTLD, unlike early graft failures associated with BKVN.
