![conference banner](/images/conference-banner.jpeg)
摘要
背景:铁载体是由大部分在低铁条件下生长的微生物和植物产生的小分子铁螯合剂。铁载体允许铁捕获并通过细胞膜转运到细胞质中,在那里铁被释放出来用于生物过程。这些细菌铁吸收系统可用于抗生素结合或作为杀死病原细菌的靶标。由于铁载体在环境和治疗研究中的潜在应用,因此最近对其进行了研究。它们存在于革兰氏阳性菌链霉菌中,是发现新铁载体的重要来源。 目的:这篇综述总结了链霉菌属产生的铁载体分子,强调了其作为生物技术生产者的潜力,还阐明了用于发现可用于治疗细菌感染的铁载体的基因组工具。 方法:使用PUBMED和MEDLINE数据库进行文献检索,关键词为铁载体,次生代谢物,特洛伊木马策略,铁霉素和链霉菌。文献研究集中于书目数据库,包括链霉菌属中鉴定的所有铁载体。此外,通过使用antiSMASH平台,将GenBank链霉菌的参考基因组用于鉴定铁载体生物合成基因簇。 结果:这篇综述着重介绍了链霉菌产生的许多铁载体分子,说明了其化学结构的多样性以及对病原菌的广泛生物活性。此外,使用与抗生素偶联的铁载体可能是克服细菌对药物耐药性的替代方法,并可以提高其治疗效果。 结论:这项审查证实了链霉菌作为铁载体的丰富来源的重要性,并强调了其作为抗菌剂的潜力。
关键词: 铁载体,链霉菌,放线菌,铁霉素,细菌感染,“特洛伊木马”方法。
[http://dx.doi.org/10.1128/MMBR.00019-15] [PMID: 26609051]
[http://dx.doi.org/10.1016/j.resmic.2012.07.005] [PMID: 22922402]
[http://dx.doi.org/10.1155/2013/264020] [PMID: 23691495]
[http://dx.doi.org/10.1038/nrd3975] [PMID: 23629505]
[http://dx.doi.org/10.12688/f1000research.9534.1] [PMID: 27990276]
[PMID: 25859123]
[http://dx.doi.org/10.3122/jabfm.2013.05.120247] [PMID: 24004702]
[http://dx.doi.org/10.1016/j.cmi.2015.12.002] [PMID: 26706614]
[http://dx.doi.org/10.1016/j.jiac.2014.08.001] [PMID: 25172776]
[http://dx.doi.org/10.1056/NEJMra0904124] [PMID: 20463340]
[http://dx.doi.org/10.1378/chest.14-2171] [PMID: 25940252]
[http://dx.doi.org/10.1155/2016/2475067] [PMID: 27274985]
[http://dx.doi.org/10.1016/j.tips.2010.08.002] [PMID: 20843562]
[http://dx.doi.org/10.1016/S1473-3099(17)30753-3] [PMID: 29276051]
[http://dx.doi.org/10.1016/j.jiph.2016.08.007] [PMID: 27616769]
[http://dx.doi.org/10.1016/j.freeradbiomed.2016.10.489] [PMID: 27780750]
[http://dx.doi.org/10.1159/000494627] [PMID: 30605903]
[http://dx.doi.org/10.1139/cjm-2014-0063] [PMID: 24588388]
[http://dx.doi.org/10.1016/j.micres.2017.10.012] [PMID: 29103733]
[http://dx.doi.org/10.1111/1751-7915.12117] [PMID: 24576157]
[http://dx.doi.org/10.1111/ele.12878] [PMID: 29161760]
[http://dx.doi.org/10.1039/C4DT03559C] [PMID: 25764171]
[http://dx.doi.org/10.1021/cr900112r] [PMID: 19754138]
[http://dx.doi.org/10.1093/femsre/fuv049] [PMID: 26684538]
[http://dx.doi.org/10.35196/rfm.2012.1.9]
[http://dx.doi.org/10.1111/2049-632X.12132] [PMID: 24436170]
[http://dx.doi.org/10.1007/s11356-015-4294-0] [PMID: 25758420]
[http://dx.doi.org/10.1006/abbi.1999.1518] [PMID: 10620317]
[http://dx.doi.org/10.1111/mmi.12709] [PMID: 25040830]
[http://dx.doi.org/10.1016/j.tibs.2015.11.012] [PMID: 26725301]
[http://dx.doi.org/10.1371/journal.pone.0034591] [PMID: 22514641]
[http://dx.doi.org/10.1128/AEM.03520-14] [PMID: 25724953]
[http://dx.doi.org/10.1111/mmi.12008] [PMID: 22931126]
[http://dx.doi.org/10.1016/j.bbamem.2007.07.026] [PMID: 17916327]
[http://dx.doi.org/10.1007/s00253-010-2550-2] [PMID: 20352420]
[http://dx.doi.org/10.1073/pnas.1304235110] [PMID: 23924612]
[http://dx.doi.org/10.1016/j.molmed.2016.10.005] [PMID: 27825668]
[http://dx.doi.org/10.1039/b804465c] [PMID: 20372697]
[http://dx.doi.org/10.1039/C8NP00012C] [PMID: 29721572]
[http://dx.doi.org/10.1016/j.bjid.2012.08.014] [PMID: 22975171]
[http://dx.doi.org/10.1016/j.biotechadv.2013.10.008] [PMID: 24189093]
[http://dx.doi.org/10.1111/j.1574-6968.2001.tb10556.x] [PMID: 11267771]
[http://dx.doi.org/10.1038/ja.2017.26] [PMID: 28246378]
[http://dx.doi.org/10.1021/np200290j] [PMID: 22014204]
[http://dx.doi.org/10.3390/md11051524] [PMID: 23665958]
[http://dx.doi.org/10.1039/c1dt11804h] [PMID: 22261733]
[http://dx.doi.org/10.1099/mic.0.047977-0] [PMID: 21757492]
[http://dx.doi.org/10.1039/C39900001194]
[http://dx.doi.org/10.1038/sj.bjp.0704507] [PMID: 11906952]
[http://dx.doi.org/10.1039/b801016a] [PMID: 18452021]
[http://dx.doi.org/10.3923/pjbs.2010.546.550] [PMID: 21848068]
[http://dx.doi.org/10.1021/jm400265k] [PMID: 23614627]
[http://dx.doi.org/10.1007/s12291-012-0197-8] [PMID: 26405387]
[http://dx.doi.org/10.1007/BF00173718] [PMID: 1367428]
[http://dx.doi.org/10.1128/JB.160.1.304-312.1984] [PMID: 6480557]
[http://dx.doi.org/10.1007/BF00294289]
[http://dx.doi.org/10.1021/acschembio.7b00597] [PMID: 28945067]
[http://dx.doi.org/10.1021/acs.jnatprod.6b00478] [PMID: 28128554]
[http://dx.doi.org/10.7164/antibiotics.38.1813] [PMID: 3005216]
[PMID: 3108212]
[http://dx.doi.org/10.1007/s10534-008-9199-7] [PMID: 19130258]
[http://dx.doi.org/10.1039/b906679a] [PMID: 20376388]
[http://dx.doi.org/10.3390/molecules24183314] [PMID: 31514464]
[http://dx.doi.org/10.3181/00379727-64-15695] [PMID: 20285459]
[http://dx.doi.org/10.1128/AEM.02517-15] [PMID: 26519385]
[http://dx.doi.org/10.1021/cb300173x] [PMID: 22704654]
[http://dx.doi.org/10.1038/s41467-018-05821-1] [PMID: 30181560]
[http://dx.doi.org/10.1002/hlca.19950780105]
[http://dx.doi.org/10.1007/s10534-009-9218-3] [PMID: 19221879]
[http://dx.doi.org/10.1128/AEM.00586-07] [PMID: 17720843]
[PMID: 14037612]
[http://dx.doi.org/10.1007/BF02157712] [PMID: 13800479]
[PMID: 14157008]
[http://dx.doi.org/10.11554/antibioticsa.16.2_67]]
[http://dx.doi.org/10.2174/0929867003375353] [PMID: 10637361]
[http://dx.doi.org/10.1111/nyas.12024] [PMID: 23346861]
[http://dx.doi.org/10.1016/j.tips.2014.06.007] [PMID: 25108321]
[http://dx.doi.org/10.1021/acs.jmedchem.7b00554] [PMID: 28453272]
[http://dx.doi.org/10.3389/fmicb.2014.00290] [PMID: 24971080]
[http://dx.doi.org/10.1016/j.cmi.2018.03.037] [PMID: 29649600]
[http://dx.doi.org/10.3390/molecules24183314] [PMID: 31514464]
[http://dx.doi.org/10.1016/S1369-5274(02)00298-9] [PMID: 11934617]
[http://dx.doi.org/10.1128/JB.00205-06] [PMID: 16707680]
[http://dx.doi.org/10.1021/ja503911p] [PMID: 24927110]
[http://dx.doi.org/10.1016/j.bmc.2012.04.034] [PMID: 22608921]
[http://dx.doi.org/10.1016/S0968-0896(02)00044-5] [PMID: 11937324]
[http://dx.doi.org/10.1021/jm990508g] [PMID: 11405651]
[http://dx.doi.org/10.1039/c3ob40162f] [PMID: 23575952]
[http://dx.doi.org/10.1016/j.bmcl.2017.09.039] [PMID: 28947150]
[http://dx.doi.org/10.1039/c1ob06250f] [PMID: 22052022]
[http://dx.doi.org/10.1007/s10534-015-9830-3] [PMID: 25663417]
[http://dx.doi.org/10.1016/j.bmcl.2006.11.005] [PMID: 17123817]
[http://dx.doi.org/10.1021/bc300610f] [PMID: 23350642]
[http://dx.doi.org/10.1021/ml300150y] [PMID: 23264853]
[http://dx.doi.org/10.1021/acs.jmedchem.7b00102] [PMID: 28287735]
[http://dx.doi.org/10.1016/S1473-3099(18)30554-1] [PMID: 30509675]
[http://dx.doi.org/10.4137/IDRT.S31567] [PMID: 27773991]
[http://dx.doi.org/10.1021/acs.jmedchem.8b00218] [PMID: 29554424]
[http://dx.doi.org/10.1111/1751-7915.12353]
[http://dx.doi.org/10.1016/j.tibtech.2017.10.009] [PMID: 29126570]
[http://dx.doi.org/10.1111/1751-7915.12143] [PMID: 25100265]
[http://dx.doi.org/10.1016/j.synbio.2015.12.002] [PMID: 29062930]
[http://dx.doi.org/10.1007/s12038-017-9663-z] [PMID: 28229977]
[http://dx.doi.org/10.1016/S0076-6879(09)04817-4] [PMID: 19374993]
[http://dx.doi.org/10.1128/MMBR.66.2.223-249.2002] [PMID: 12040125]
[http://dx.doi.org/10.1128/MMBR.00012-07] [PMID: 17804665]
[http://dx.doi.org/10.1590/S1517-83822013000400002] [PMID: 24688489]
[http://dx.doi.org/10.1021/jm700948z] [PMID: 18393407]
[http://dx.doi.org/10.1093/nar/gkx319] [PMID: 28460038]
[http://dx.doi.org/10.1007/s10295-015-1685-7] [PMID: 26433383]
[http://dx.doi.org/10.1128/AEM.01383-16] [PMID: 27451447]
[http://dx.doi.org/10.1038/nchembio731] [PMID: 16408055]
[http://dx.doi.org/10.1007/s10295-013-1327-x] [PMID: 23990133]
[http://dx.doi.org/10.1021/sb3001003] [PMID: 23654282]
[http://dx.doi.org/10.1039/b817069j] [PMID: 19844637]
[http://dx.doi.org/10.1007/s00253-012-4268-9] [PMID: 22825833]
[http://dx.doi.org/10.1016/j.jbiotec.2017.12.024] [PMID: 29307836]
[http://dx.doi.org/10.1039/c3ob40536b] [PMID: 23752895]
[http://dx.doi.org/10.1128/JB.01250-09] [PMID: 19915026]
![Wayfinder Image](/images/wayfinder.jpg)