Abstract
RNA molecules are the only known molecules which possess the double property of being depository of genetic information, like DNA, and of displaying catalytic activities, like protein enzymes. RNA molecules intervene in all steps of gene expression and in many other biological activities. Like proteins, RNAs achieve those biological functions by adopting intricate three-dimensional folds and architectures. Further, as in protein sequences, RNA sequences contain signatures specific for three-dimensional motifs which participate in recognition and binding. In regulatory pathways, RNA molecules exist in equilibria between transient structures differentially stabilized by effectors such as proteins or cofactors. Therefore, RNA molecules display their potential as drug targets on different levels, namely in three-dimensional folds, in structural equilibria and in RNA-protein interfaces. Several examples will be described together with the already available techniques for combinatorial synthesis and high-t hroughput screening of potential drug and target RNA molecules.
Keywords: Drug design, High throughput, RNA targets, RNA molecules, Expressed sequence tags
Combinatorial Chemistry & High Throughput Screening
Title: Rational Drug Design and High-Throughput Techniques for RNA Targets
Volume: 3 Issue: 3
Author(s): Thomas Hermann and Eric Westhof
Affiliation:
Keywords: Drug design, High throughput, RNA targets, RNA molecules, Expressed sequence tags
Abstract: RNA molecules are the only known molecules which possess the double property of being depository of genetic information, like DNA, and of displaying catalytic activities, like protein enzymes. RNA molecules intervene in all steps of gene expression and in many other biological activities. Like proteins, RNAs achieve those biological functions by adopting intricate three-dimensional folds and architectures. Further, as in protein sequences, RNA sequences contain signatures specific for three-dimensional motifs which participate in recognition and binding. In regulatory pathways, RNA molecules exist in equilibria between transient structures differentially stabilized by effectors such as proteins or cofactors. Therefore, RNA molecules display their potential as drug targets on different levels, namely in three-dimensional folds, in structural equilibria and in RNA-protein interfaces. Several examples will be described together with the already available techniques for combinatorial synthesis and high-t hroughput screening of potential drug and target RNA molecules.
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Cite this article as:
Hermann Thomas and Westhof Eric, Rational Drug Design and High-Throughput Techniques for RNA Targets, Combinatorial Chemistry & High Throughput Screening 2000; 3 (3) . https://dx.doi.org/10.2174/1386207003331652
DOI https://dx.doi.org/10.2174/1386207003331652 |
Print ISSN 1386-2073 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5402 |
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