Title:Targeting Autophagic Pathways by Plant Natural Compounds in Cancer Treatment
Volume: 21
Issue: 12
关键词:
自噬途径,草药,癌症,姜黄素,白藜芦醇,冬凌草素
摘要: Nowadays, natural compounds of plant origin with anticancer effects have gained more attention
because of their clinical safety and broad efficacy profiles. Autophagy is a multistep lysosomal
degradation pathway that may have a unique potential for clinical benefit in the setting of cancer
treatment. To retrieve articles related to the study, the databases of Google Scholar, Web of sciences,
Medline and Scopus, using the following keywords: Autophagic pathways; herbal medicine, oncogenic
autophagic pathways, tumor-suppressive autophagic pathways, and cancer were searched. Although
natural plant compounds such as resveratrol, curcumin, oridonin, gossypol, and paclitaxel have proven
anticancer potential via autophagic signaling pathways, there is still a great need to find new natural
compounds and investigate the underlying mechanisms, to facilitate their clinical use as potential anticancer
agents through autophagic induction.