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Current Neuropharmacology


ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

Review Article

Sleep Disturbances and Cognitive Impairment in the Course of Type 2 Diabetes-A Possible Link

Author(s): Anna Brzecka*, Natalia Madetko , Vladimir N. Nikolenko, Ghulam M. Ashraf, Maria Ejma , Jerzy Leszek, Cyryl Daroszewski, Karolina Sarul, Liudmila M. Mikhaleva, Siva G. Somasundaram, Cecil E. Kirkland, Sergey O. Bachurin and Gjumrakch Aliev*

Volume 19, Issue 1, 2021

Published on: 08 March, 2020

Page: [78 - 91] Pages: 14

DOI: 10.2174/1570159X18666200309101750

Price: $65


There is an increasing number of patients worldwide with sleep disturbances and diabetes. Various sleep disorders, including long or short sleep duration and poor sleep quality of numerous causes, may increase the risk of diabetes. Some symptoms of diabetes, such as painful peripheral neuropathy and nocturia, or associated other sleep disorders, such as sleep breathing disorders or sleep movement disorders, may influence sleep quality and quantity. Both sleep disorders and diabetes may lead to cognitive impairment. The risk of development of cognitive impairment in diabetic patients may be related to vascular and non-vascular and other factors, such as hypoglycemia, hyperglycemia, central insulin resistance, amyloid and tau deposits and other causes. Numerous sleep disorders, e.g., sleep apnea, restless legs syndrome, insomnia, and poor sleep quality are most likely are also associated with cognitive impairment. Adequate functioning of the system of clearance of the brain from toxic substances, such as amyloid β, i.e. glymphatic system, is related to undisturbed sleep and prevents cognitive impairment. In the case of coexistence, sleep disturbances and diabetes either independently lead to and/or mutually aggravate cognitive impairment.

Keywords: Insulin, hypoglycemia, hyperglycemia, dementia, sleep apnea, glymphatic system, central nervous system, risk factors.

Graphical Abstract
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