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Review Article

线粒体相关膜（MAMs）：一种新型的代谢综合征的治疗靶标。

卷 28, 期 7, 2021

发表于: 12 February, 2020

页: [1347 - 1362] 页: 16

弟呕挨: 10.2174/0929867327666200212100644

价格: $65

摘要

线粒体相关的内质网（ER）膜（MAM）是连接ER和线粒体并介导这两个细胞器之间通讯的细胞结构。 已证明MAMs参与钙信号传导，脂质转移，线粒体动态变化，线粒体和ER应激反应。 此外，MAMs对代谢调节至关重要，据报道其功能障碍与代谢综合征有关，包括胰岛素信号下调和高脂血症，肥胖症和高血压的加速发展。 这篇综述涵盖了MAMs在调节胰岛素敏感性中的作用以及MAMs调控细胞代谢的分子机制，并揭示了MAMs作为治疗代谢综合征的潜在治疗靶点的潜力。

关键词: 线粒体，内质网（ER），线粒体相关膜（MAM），代谢综合征，糖尿病，胰岛素抵抗。

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