Abstract
The mouse has long been an important component of cancer research. From the realization by Little and Bagg early days of the past century demonstrating a heritable component of sponanteous cancer to the oncogenic manipulations of the germline today, the mouse has been and will continue to be the major mammalian in vivo system to study neoplasic transformation and progression. Use of the mouse has pervaded almost every aspect of cancer research, including discovery of oncogenes, analysis of tumor suppressors, development of novel therapeutic strategies, and exploring the mutagenic effects of chemicals and ionizing radiation, to name a few. The development over the last twenty years of transgenic, homologous recombination and conditional-transgenic or knockout technologies has enormously expanded the breadth and scope of the mouse in cancer research and has contributed significantly to our understanding of the events that lead up to and accompany neoplastic transformation. Although there are significant limitations of modeling human cancers in the mouse, these proven technologies as well as technologies currently under development, will continue to provide experimentally tractable systems in which to explore the genetic and molecular events of cancer initiation and progression. As a result, the mouse as a model for human neoplastic disease will continue to have a significant place in the experimental toolbox of cancer researchers for many years to come.
Keywords: Neoplastic transformation, cancer research, tumor suppressor, oncogenes, conditional transgenic, testicular tumors, pharmacokinetics, virally induced, xenograft system, chemical carcinogenesis, transgenics
Current Genomics
Title: The Mouse In Cancer Research Past, Present, Future
Volume: 2 Issue: 1
Author(s): K. Hunter and D. Cozma
Affiliation:
Keywords: Neoplastic transformation, cancer research, tumor suppressor, oncogenes, conditional transgenic, testicular tumors, pharmacokinetics, virally induced, xenograft system, chemical carcinogenesis, transgenics
Abstract: The mouse has long been an important component of cancer research. From the realization by Little and Bagg early days of the past century demonstrating a heritable component of sponanteous cancer to the oncogenic manipulations of the germline today, the mouse has been and will continue to be the major mammalian in vivo system to study neoplasic transformation and progression. Use of the mouse has pervaded almost every aspect of cancer research, including discovery of oncogenes, analysis of tumor suppressors, development of novel therapeutic strategies, and exploring the mutagenic effects of chemicals and ionizing radiation, to name a few. The development over the last twenty years of transgenic, homologous recombination and conditional-transgenic or knockout technologies has enormously expanded the breadth and scope of the mouse in cancer research and has contributed significantly to our understanding of the events that lead up to and accompany neoplastic transformation. Although there are significant limitations of modeling human cancers in the mouse, these proven technologies as well as technologies currently under development, will continue to provide experimentally tractable systems in which to explore the genetic and molecular events of cancer initiation and progression. As a result, the mouse as a model for human neoplastic disease will continue to have a significant place in the experimental toolbox of cancer researchers for many years to come.
Export Options
About this article
Cite this article as:
Hunter K. and Cozma D., The Mouse In Cancer Research Past, Present, Future, Current Genomics 2001; 2 (1) . https://dx.doi.org/10.2174/1389202013351165
DOI https://dx.doi.org/10.2174/1389202013351165 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
Call for Papers in Thematic Issues
Advanced AI Techniques in Big Genomic Data Analysis
The thematic issue on "Advanced AI Techniques in Big Genomic Data Analysis" aims to explore the cutting-edge methodologies and applications of artificial intelligence (AI) in the realm of genomic research, where vast amounts of data pose both challenges and opportunities. This issue will cover a broad spectrum of AI-driven strategies, ...read more
Advanced Computational Algorithms and Artificial Intelligence in Clinical Pharmacogenomics
In the era of personalized medicine, understanding the relationship between genetics and drug response is crucial. This issue delves into innovative methodologies, leveraging deep computational analysis and artificial intelligence, to enhance the field of Clinical Pharmacogenomics. The interdisciplinary approach harnesses the power of advanced high-throughput genotyping technologies, sophisticated computational analysis, ...read more
Applications of Single-cell Sequencing Technology in Reproductive Medicine
Single cell sequencing (SCS) technology utilizes individual cells' genetic material to sequence their genome, transcriptome, and epigenetics at the molecular level. It offers insights into cell heterogeneity and enables the study of limited biological materials. Since its recognition as a valuable technique in 2011, single cell sequencing has yielded numerous ...read more
Current Genomics in Cardiovascular Research
Cardiovascular diseases are the main cause of death in the world, in recent years we have had important advances in the interaction between cardiovascular disease and genomics. In this Research Topic, we intend for researchers to present their results with a focus on basic, translational and clinical investigations associated with ...read more
Related Journals
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Use of Mouse Models to Evaluate Roles of Nuclear Receptors and their Ligands in the Pathogenesis and Treatment of Atherosclerosis
Current Drug Targets Gliomagenesis and the Use of Neural Stem Cells in Brain Tumor Treatment
Anti-Cancer Agents in Medicinal Chemistry Molecular Pathogenesis of Philadelphia-Positive Chronic Myeloid Leukemia – is it all BCR-ABL?
Current Cancer Drug Targets Steroid Regulation of Drug-Metabolizing Cytochromes P450
Current Drug Metabolism STAT3: A Molecular Target for Cancer Whose Time Has Come
Current Signal Transduction Therapy CASC15: A Tumor-Associated Long Non-Coding RNA
Current Pharmaceutical Design The Epigenetic Origin of Aneuploidy
Current Genomics Drug Discovery Using Yeast as a Model System: A Functional Genomic and Proteomic View
Current Proteomics Gliomas: Current Issues in Diagnosis and Treatment
Current Medical Imaging CDC25A: A Rebel Within the CDC25 Phosphatases Family?
Anti-Cancer Agents in Medicinal Chemistry Bioenergetics and Mitochondrial Dysfunction in Aging: Recent Insights for a Therapeutical Approach
Current Pharmaceutical Design Adult Neurogenesis in the Hypothalamus: Evidence, Functions and Implications
CNS & Neurological Disorders - Drug Targets Therapeutic Effects of Vitamin D in Asthma and Allergy
Mini-Reviews in Medicinal Chemistry Prognostic Biomarkers of Cutaneous Malignancies – Serological, Immunohistochemical and Proteomic Approaches
Current Cancer Therapy Reviews Perspectives in Cell Cycle Regulation: Lessons from an Anoxic Vertebrate
Current Genomics Historical Spice as a Future Drug: Therapeutic Potential of Piperlongumine
Current Pharmaceutical Design Critical microRNAs in Lung Cancer: Recent Advances and Potential Applications
Anti-Cancer Agents in Medicinal Chemistry p53: A Guide to Apoptosis
Current Cancer Drug Targets Subject Index to Volume 3
Current Medicinal Chemistry - Anti-Cancer Agents Stem Cell Differentiation Stage Factors from Zebrafish Embryo: A Novel Strategy to Modulate the Fate of Normal and Pathological Human (Stem) Cells
Current Pharmaceutical Biotechnology