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Current Analytical Chemistry

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ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

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Review Article

AIE Luminogens as Versatile Bioprobes

Author(s): Moustafa T. Gabr and F. Christopher Pigge*

Volume 17, Issue 3, 2021

Published on: 10 January, 2020

Page: [302 - 316] Pages: 15

DOI: 10.2174/1573411016666200110153737

Price: $65

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Abstract

Background: Luminogens that feature aggregation induced emission (AIE) are typically non-emissive in solution but become highly luminescent upon aggregation in poor solvents or solid state.

Discussion: Unlike conventional fluorophores that exhibit aggregation-caused quenching (ACQ), utilization of AIE luminogens as bioprobes has featured superior photostability, low background signal, large Stokes’ shifts, high sensitivity and turn-on luminescent response.

Conclusion: The versatility of AIE-based luminogens as bioprobes has been demonstrated through various applications in cell organelle imaging, ion sensing and sensitive detection of biomacromolecules. Examples of AIE-based luminogens and their applications as luminescent sensors for biosensing and optical imaging are discussed herein.

Keywords: Aggregation, bioprobes, fluorescence, luminescence, organelle imaging, sensors.

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