Abstract
Mast cells (MCs) bear many receptors that allow them to respond to a variety of exogenous and endogenous stimuli. However, MC function is dual since they can initiate pathological events or protect the host against infectious challenges.
The role of MCs in disease will be analyzed in a broad sense, describing cellular and molecular mechanisms related to their involvement in auto-inflammatory diseases, asthma, autoimmune diseases and cancer. On the other hand, their protective role in the course of bacterial, fungal and parasitic infections will also be illustrated.
As far as treatment of MC-derived diseases is concerned, allergen immunotherapy as well as other attempts to reduce MC-activation will be outlined according to the recent data. Finally, in agreement with current literature and our own data polyphenols have been demonstrated to attenuate type I allergic reactions and contact dermatitis in response to nickel. The use of polyphenols in these diseases will be discussed also in view of MC involvement.
Keywords: Allergy, asthma, auto-immunity, cancer, inflammation, polyphenols.
[http://dx.doi.org/10.1016/j.it.2017.04.001] [PMID: 28462845]
[http://dx.doi.org/10.1016/j.it.2017.10.005] [PMID: 29196147]
[http://dx.doi.org/10.1111/bjd.13857] [PMID: 25904179]
[http://dx.doi.org/10.1016/j.bbadis.2011.02.009] [PMID: 21354470]
[http://dx.doi.org/10.1016/j.vascn.2010.04.012] [PMID: 20452446]
[http://dx.doi.org/10.1016/j.jaci.2016.08.011] [PMID: 27619824]
[http://dx.doi.org/10.1038/nrcardio.2015.117] [PMID: 26259935]
[http://dx.doi.org/10.1158/2326-6066.CIR-13-0119] [PMID: 24777963]
[http://dx.doi.org/10.1007/978-1-4939-1568-2_7] [PMID: 25388247]
[http://dx.doi.org/10.1111/j.1365-2133.2009.09516.x] [PMID: 19785618]
[http://dx.doi.org/10.1183/13993003.00536-2015] [PMID: 26206871]
[http://dx.doi.org/10.1067/mai.2000.110930] [PMID: 11080719]
[http://dx.doi.org/10.1111/all.12006] [PMID: 22913618]
[http://dx.doi.org/10.1111/bjd.14820] [PMID: 27343477]
[http://dx.doi.org/10.1159/000087644] [PMID: 16107772]
[http://dx.doi.org/10.1111/all.12517] [PMID: 25155287]
[http://dx.doi.org/10.1016/j.coi.2010.08.015] [PMID: 20884193]
[http://dx.doi.org/10.1084/jem.188.12.2343] [PMID: 9858520]
[http://dx.doi.org/10.1016/j.jaci.2015.08.005] [PMID: 26410782]
[http://dx.doi.org/10.1038/jid.2014.222] [PMID: 24844861]
[http://dx.doi.org/10.1016/j.immuni.2012.04.013] [PMID: 22819042]
[http://dx.doi.org/10.1371/journal.pone.0025538] [PMID: 21980488]
[http://dx.doi.org/10.1016/j.celrep.2013.12.029] [PMID: 24412367]
[http://dx.doi.org/10.1111/j.1398-9995.2006.01139.x] [PMID: 16918506]
[PMID: 9300715]
[PMID: 10228025]
[http://dx.doi.org/10.1084/jem.176.5.1381] [PMID: 1402683]
[http://dx.doi.org/10.1016/j.jaci.2017.10.010] [PMID: 29221580]
[http://dx.doi.org/10.1056/NEJM198406213102502] [PMID: 6328300]
[http://dx.doi.org/10.1056/NEJM198507113130201] [PMID: 2582257]
[http://dx.doi.org/10.1016/j.jaci.2012.07.027] [PMID: 22935585]
[http://dx.doi.org/10.2174/1871530314666140325094929] [PMID: 24678739]
[http://dx.doi.org/10.1038/nature14189] [PMID: 25592534]
[http://dx.doi.org/10.1007/s00281-007-0084-1] [PMID: 17805542]
[http://dx.doi.org/10.1016/j.pharmthera.2018.02.011] [PMID: 29466702]
[http://dx.doi.org/10.1016/j.molmed.2018.01.004] [PMID: 29433944]
[http://dx.doi.org/10.1084/jem.20082179] [PMID: 19364881]
[http://dx.doi.org/10.1111/imr.12633] [PMID: 29431217]
[http://dx.doi.org/10.1002/art.38747] [PMID: 24943488]
[http://dx.doi.org/10.1016/j.ajpath.2014.08.025] [PMID: 25451151]
[http://dx.doi.org/10.1016/j.immuni.2015.06.003] [PMID: 26084020]
[http://dx.doi.org/10.1007/s00281-015-0491-7] [PMID: 25963520]
[http://dx.doi.org/10.1016/S0140-6736(04)17401-1] [PMID: 15541451]
[http://dx.doi.org/10.1016/j.jdermsci.2013.04.009] [PMID: 23684246]
[PMID: 15868622]
[http://dx.doi.org/10.1146/annurev.immunol.25.022106.141627] [PMID: 19302049]
[http://dx.doi.org/10.1542/peds.2010-2998] [PMID: 21727109]
[http://dx.doi.org/10.1111/j.1600-065X.2007.00506.x] [PMID: 17498049]
[http://dx.doi.org/10.1016/j.jaut.2016.06.015] [PMID: 27396526]
[http://dx.doi.org/10.1016/j.clim.2016.04.009] [PMID: 27108197]
[http://dx.doi.org/10.1038/nm.3806] [PMID: 25686105]
[http://dx.doi.org/10.1111/j.1365-2133.2006.07675.x] [PMID: 17223864]
[http://dx.doi.org/10.1111/bjd.12631] [PMID: 24117368]
[http://dx.doi.org/10.1111/dth.12943] [PMID: 31012218]
[http://dx.doi.org/10.1084/jem.192.10.1441] [PMID: 11085746]
[http://dx.doi.org/10.1046/j.1365-2133.2003.05090.x] [PMID: 12588371]
[http://dx.doi.org/10.1038/sj.jid.5700819] [PMID: 17429439]
[http://dx.doi.org/10.1007/s10753-013-9759-z] [PMID: 24158569]
[http://dx.doi.org/10.1016/j.immuni.2011.03.028] [PMID: 21703544]
[http://dx.doi.org/10.1056/NEJMoa012705] [PMID: 12037149]
[http://dx.doi.org/10.1111/j.1365-2222.2004.01975.x] [PMID: 15196279]
[http://dx.doi.org/10.1016/j.jaci.2009.10.074] [PMID: 20159259]
[http://dx.doi.org/10.1073/pnas.1601914113] [PMID: 27432971]
[http://dx.doi.org/10.1016/S1471-4906(02)02274-3] [PMID: 12200056]
[http://dx.doi.org/10.1016/j.intimp.2017.04.027] [PMID: 28463786]
[http://dx.doi.org/10.2174/138161211795428975] [PMID: 21410430]
[http://dx.doi.org/10.1111/j.1398-9995.2010.02372.x] [PMID: 20415716]
[http://dx.doi.org/10.1016/j.jaci.2015.03.039] [PMID: 25962901]
[PMID: 20184608]
[http://dx.doi.org/10.1111/all.13197] [PMID: 28474352]
[http://dx.doi.org/10.1111/all.13185] [PMID: 28426171]
[http://dx.doi.org/10.1016/S0368-1319(66)80045-5] [PMID: 5975281]
[http://dx.doi.org/10.1161/01.ATV.14.6.966] [PMID: 7515278]
[PMID: 7546279]
[http://dx.doi.org/10.1161/01.CIR.94.11.2787] [PMID: 8941103]
[http://dx.doi.org/10.1084/jem.20160081] [PMID: 27353089]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.107.741595] [PMID: 18606918]
[http://dx.doi.org/10.1007/s00018-013-1349-6] [PMID: 23649149]
[http://dx.doi.org/10.2174/1871530314666140307095630] [PMID: 24606838]
[http://dx.doi.org/10.3389/fimmu.2015.00076] [PMID: 25759691]
[PMID: 28243360]
[http://dx.doi.org/10.1146/annurev.immunol.26.021607.090320] [PMID: 18370925]
[http://dx.doi.org/10.1146/annurev.immunol.21.120601.141025] [PMID: 15771585]
[http://dx.doi.org/10.1016/S0140-6736(16)30173-8] [PMID: 27156434]
[http://dx.doi.org/10.3390/ijms20082040] [PMID: 31027208]
[http://dx.doi.org/10.1002/art.1780390723] [PMID: 8670335]
[http://dx.doi.org/10.1189/jlb.3HI1215-542R] [PMID: 27034403]
[http://dx.doi.org/10.1186/s13075-016-1036-8] [PMID: 27296719]
[http://dx.doi.org/10.1016/j.autrev.2017.04.001] [PMID: 28411167]
[http://dx.doi.org/10.1016/S0272-6386(98)70022-8] [PMID: 9774120]
[http://dx.doi.org/10.1016/S0140-6736(14)60128-8] [PMID: 24881804]
[http://dx.doi.org/10.1016/j.imlet.2003.11.014] [PMID: 15019275]
[http://dx.doi.org/10.1084/jem.20140066] [PMID: 25267791]
[http://dx.doi.org/10.1038/ni.3326] [PMID: 26692173]
[http://dx.doi.org/10.1038/s41598-017-08516-7] [PMID: 28801578]
[http://dx.doi.org/10.1371/journal.pone.0090424] [PMID: 24587356]
[http://dx.doi.org/10.1016/j.ajpath.2015.09.016] [PMID: 26597881]
[http://dx.doi.org/10.1111/ejh.12747] [PMID: 26872637]
[http://dx.doi.org/10.1182/blood-2008-03-147033] [PMID: 18524989]
[http://dx.doi.org/10.1038/onc.2010.348] [PMID: 20729915]
[http://dx.doi.org/10.1007/s12016-019-08753-w] [PMID: 31256327]
[http://dx.doi.org/10.1007/s101200050017] [PMID: 11957067]
[http://dx.doi.org/10.1158/0008-5472.CAN-12-4479] [PMID: 23633481]
[http://dx.doi.org/10.1046/j.1365-2141.2002.03768.x] [PMID: 12358914]
[http://dx.doi.org/10.1182/blood-2012-03-415638] [PMID: 22837530]
[http://dx.doi.org/10.1172/JCI22089] [PMID: 15520864]
[http://dx.doi.org/10.1038/modpathol.3800094] [PMID: 15044916]
[http://dx.doi.org/10.1200/JCO.2005.01.4910] [PMID: 16219934]
[http://dx.doi.org/10.2353/ajpath.2010.100070] [PMID: 20616342]
[PMID: 1375931]
[http://dx.doi.org/10.1091/mbc.9.4.875] [PMID: 9529385]
[http://dx.doi.org/10.4049/jimmunol.167.7.4008] [PMID: 11564820]
[http://dx.doi.org/10.1101/gad.13.11.1382] [PMID: 10364156]
[http://dx.doi.org/10.1177/41.11.8409368] [PMID: 8409368]
[http://dx.doi.org/10.1159/000353251] [PMID: 24217607]
[http://dx.doi.org/10.1111/1523-1747.ep12468882] [PMID: 2002248]
[http://dx.doi.org/10.1146/annurev.med.55.091902.103822] [PMID: 14746529]
[http://dx.doi.org/10.1007/s00277-002-0575-z] [PMID: 12483363]
[http://dx.doi.org/10.1111/cea.12225] [PMID: 24164252]
[http://dx.doi.org/10.1111/cea.12318] [PMID: 24702655]
[http://dx.doi.org/10.3390/ijms20122976] [PMID: 31216696]
[http://dx.doi.org/10.3390/ijms20122851] [PMID: 31212724]
[http://dx.doi.org/10.1038/nm1615] [PMID: 17643110]
[http://dx.doi.org/10.2174/1381612824666180403123736] [PMID: 29611476]
[http://dx.doi.org/10.2174/1381612824666180327155230] [PMID: 29589541]
[http://dx.doi.org/10.4049/jimmunol.180.11.7565] [PMID: 18490758]
[http://dx.doi.org/10.4049/jimmunol.181.8.5598] [PMID: 18832718]
[http://dx.doi.org/10.1111/imr.12623] [PMID: 29431211]
[http://dx.doi.org/10.1016/j.immuni.2016.11.003] [PMID: 27939674]
[http://dx.doi.org/10.2353/ajpath.2010.090342] [PMID: 20035049]
[http://dx.doi.org/10.1016/j.immuni.2012.10.019] [PMID: 23415912]
[http://dx.doi.org/10.1016/j.imbio.2015.09.004] [PMID: 26421959]
[http://dx.doi.org/10.1007/s10753-014-9951-9] [PMID: 24950781]
[http://dx.doi.org/10.1038/mi.2007.13] [PMID: 19079173]
[http://dx.doi.org/10.1038/srep12287] [PMID: 26192381]
[http://dx.doi.org/10.2174/9781608059850114020013]
[http://dx.doi.org/10.2174/1871530316666160506150349] [PMID: 27150602]
[http://dx.doi.org/10.2174/1871530318666171129211350] [PMID: 29189183]
[http://dx.doi.org/10.1038/32190] [PMID: 9510253]
[http://dx.doi.org/10.1084/jem.20042202] [PMID: 16129701]
[http://dx.doi.org/10.1111/pim.1993.15.10.565] [PMID: 7877833]
[http://dx.doi.org/10.1073/pnas.1112268109] [PMID: 22493240]
[PMID: 6345400]
[http://dx.doi.org/10.1128/IAI.00053-17] [PMID: 28264908]
[http://dx.doi.org/10.1056/NEJM199908123410702] [PMID: 10441602]
[http://dx.doi.org/10.1186/1939-4551-7-6] [PMID: 24679069]
[http://dx.doi.org/10.1016/j.jaci.2008.01.072] [PMID: 18374405]
[http://dx.doi.org/10.1016/j.jaci.2003.11.001] [PMID: 14767435]
[http://dx.doi.org/10.1111/all.12608] [PMID: 25773990]
[http://dx.doi.org/10.1016/j.jaci.2017.09.022] [PMID: 29045815]
[http://dx.doi.org/10.4049/jimmunol.172.5.3252] [PMID: 14978133]
[http://dx.doi.org/10.4049/jimmunol.178.7.4658] [PMID: 17372025]
[http://dx.doi.org/10.1067/mai.2001.112263] [PMID: 11295653]
[http://dx.doi.org/10.1016/S0091-6749(97)70106-4] [PMID: 9042055]
[http://dx.doi.org/10.1016/j.jaci.2012.02.014] [PMID: 22464673]
[http://dx.doi.org/10.1002/14651858.CD003559.pub4] [PMID: 24414989]
[http://dx.doi.org/10.1016/j.jaci.2013.05.013] [PMID: 23810097]
[http://dx.doi.org/10.1177/039463201202500217] [PMID: 22697079]
[http://dx.doi.org/10.1080/00325481.2017.1321945] [PMID: 28427296]
[http://dx.doi.org/10.1016/j.jaci.2006.02.028] [PMID: 16751018]
[PMID: 10352311]
[http://dx.doi.org/10.1038/nri3786] [PMID: 25534623]
[http://dx.doi.org/10.1007/5584_2016_29] [PMID: 27334730]
[http://dx.doi.org/10.1016/j.jaci.2014.02.005] [PMID: 24642143]
[http://dx.doi.org/10.1016/j.jaci.2014.03.007] [PMID: 24767877]
[http://dx.doi.org/10.1016/j.jaci.2015.12.1313] [PMID: 26915677]
[http://dx.doi.org/10.1111/bph.12038] [PMID: 23121409]
[http://dx.doi.org/10.1111/cea.12370] [PMID: 25040039]
[http://dx.doi.org/10.1016/j.jaci.2012.07.014] [PMID: 22939756]
[http://dx.doi.org/10.1038/sj.bjp.0707002] [PMID: 17200674]
[http://dx.doi.org/10.1007/s11899-015-0280-3] [PMID: 26404639]
[http://dx.doi.org/10.1158/2159-8290.CD-NB2016-165] [PMID: 28077435]
[http://dx.doi.org/10.1016/j.pharmthera.2012.06.005] [PMID: 22749793]
[http://dx.doi.org/10.1073/pnas.0803725105] [PMID: 19001265]
[http://dx.doi.org/10.1016/j.jaci.2012.10.056] [PMID: 23374268]
[http://dx.doi.org/10.2500/aap.2011.32.3453] [PMID: 21535913]
[http://dx.doi.org/10.1056/NEJMoa052916] [PMID: 17021320]
[http://dx.doi.org/10.1016/j.jaci.2015.12.1299] [PMID: 26853127]
[http://dx.doi.org/10.1016/j.jaci.2016.11.043] [PMID: 28236469]
[http://dx.doi.org/10.1016/j.jaci.2014.09.012]
[http://dx.doi.org/10.1016/j.ebiom.2016.08.022] [PMID: 27650868]
[http://dx.doi.org/10.1016/j.ejphar.2017.09.044] [PMID: 28970014]
[http://dx.doi.org/10.1016/B978-0-12-398456-2.00035-9]
[http://dx.doi.org/10.2174/138161208786264179] [PMID: 18991694]
[http://dx.doi.org/10.2174/138161212798919011] [PMID: 22211687]
[http://dx.doi.org/10.2174/2212707002666150402225920]
[http://dx.doi.org/10.3109/08923970903513139] [PMID: 20100066]
[http://dx.doi.org/10.3109/08923971003604786] [PMID: 20136581]
[http://dx.doi.org/10.2174/1871530317666171003161314] [PMID: 28982342]
![Wayfinder Image](/images/wayfinder.jpg)