Abstract
Antisense oligonucleotide (ASO) biotechnology has been widely used to inhibit the expression of proteins involved in human disease. ASOs are designed to bind messenger RNA transcripts via Watson-Crick base-pairing and inhibit synthesis of targeted proteins. These proteins include protein kinases, growth factors, glutamate receptors, anti-apoptotic proteins, and proteins involved in genetic disorders. Non-mRNA targets such as the RNA component of the telomerase enzyme are also being explored. Pre-clinical and clinical trials using ASO biotechnology have progressed with standard ASOs such as phosphorothioates, but newer ASO analogs are rapidly being developed with the idea of enhancing specificity and biological activity. A current major research thrust is the design and testing of antisense oligonucleotides as anti-cancer drugs. The primary focus of this review is an analysis of recent uses of ASO biotechnology to inhibit anti-apoptotic gene expression in tumor cells.
Keywords: Anti-Apoptotic Proteins, Antisense Oligonucleotides, Neurodegenerative disorders, Crohns disease, Inflammatory Disorders, Hypertension, Beta-thalassemia, Cystic fibrosis, protein kinase A, testosterone-repressed prostate message, telomease, intrleukin
Current Drug Targets
Title: Targeting the Expression of Anti-Apoptotic Proteins by Antisense Oligonucleotides
Volume: 2 Issue: 2
Author(s): Nicholas Delihas
Affiliation:
Keywords: Anti-Apoptotic Proteins, Antisense Oligonucleotides, Neurodegenerative disorders, Crohns disease, Inflammatory Disorders, Hypertension, Beta-thalassemia, Cystic fibrosis, protein kinase A, testosterone-repressed prostate message, telomease, intrleukin
Abstract: Antisense oligonucleotide (ASO) biotechnology has been widely used to inhibit the expression of proteins involved in human disease. ASOs are designed to bind messenger RNA transcripts via Watson-Crick base-pairing and inhibit synthesis of targeted proteins. These proteins include protein kinases, growth factors, glutamate receptors, anti-apoptotic proteins, and proteins involved in genetic disorders. Non-mRNA targets such as the RNA component of the telomerase enzyme are also being explored. Pre-clinical and clinical trials using ASO biotechnology have progressed with standard ASOs such as phosphorothioates, but newer ASO analogs are rapidly being developed with the idea of enhancing specificity and biological activity. A current major research thrust is the design and testing of antisense oligonucleotides as anti-cancer drugs. The primary focus of this review is an analysis of recent uses of ASO biotechnology to inhibit anti-apoptotic gene expression in tumor cells.
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Cite this article as:
Delihas Nicholas, Targeting the Expression of Anti-Apoptotic Proteins by Antisense Oligonucleotides, Current Drug Targets 2001; 2 (2) . https://dx.doi.org/10.2174/1389450013348678
DOI https://dx.doi.org/10.2174/1389450013348678 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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