Title:Plant Polyphenols as Neuroprotective Agents in Parkinson’s Disease Targeting Oxidative Stress
Volume: 21
Issue: 5
关键词:
抗氧化剂,帕金森氏病,多酚,氧化应激,神经保护,生物利用度。
摘要: Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disorder
characterized by the degeneration of dopaminergic neurons in the human midbrain. Various ongoing
research studies are competing to understand the pathology of PD and elucidate the mechanisms
underlying neurodegeneration. Current pharmacological treatments primarily focused on improving
dopamine metabolism in PD patients, despite the side effects of long-term usage. In recent years, it is
recognized that oxidative stress-mediated pathways lead to neurodegeneration in the brain, which is
associated with the pathophysiology of PD. The importance of oxidative stress is often less emphasized
when developing potential therapeutic approaches. Natural plant antioxidants have been shown
to mediate the oxidative stress-induced effects in PD, which has gained considerable attention in both
in vitro and in vivo studies. Yet, clinical trials on natural polyphenol compounds are limited, restricting
the potential use of these compounds as an alternative treatment for PD. Therefore, this review
provides an understanding of the oxidative stress-induced effects in PD by elucidating the underlying
events contributing to oxidative stress and explore the potential use of polyphenols in improving the
oxidative status in PD. Preclinical findings have supported the potential of polyphenols in providing
neuroprotection against oxidative stress-induced toxicity in PD. However, limiting factors, such as
safety and bioavailability of polyphenols, warrant further investigations so as to make them the potential
target for clinical applications in the treatment and management of PD.