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摘要
多发性硬化症(MS)是一种与脊髓和大脑有关的自身免疫性疾病,主要影响白质。关于该疾病的复杂性和异源病因,迄今为止,MS的治疗一直是具有挑战性的问题。研究人员正在努力开发新的治疗策略和药物,作为补充疗法。 MS诊断很大程度上取决于磁共振成像(MRI)检查的结果。在这种成像技术中,钆被用作造影剂以揭示打算破坏血脑屏障的活性斑块。它还可以检测与神经系统症状无关的斑块。已经尝试确定在人体解剖学的各种组织层次结构水平(即细胞,蛋白质,RNA和DNA)中与MS的不同维度有关的生物标记。这些生物标记物是用于MS诊断的合适诊断工具。在这篇综述中,我们总结了MRI和生化生物标记物在监测MS患者中的应用。此外,我们强调了MRI和生物标志物在MS受试者诊断中的联合应用。
关键词: 多发性硬化症,磁共振成像,生物标志物,自身免疫性疾病,RNA,DNA。
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