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摘要
Neuromedin U肽序列在各种物种之间高度保守。 Neuromedin U参与多种生理过程。 它通过两种神经介素U受体NMUR1和NMUR2发挥作用。 这些受体的特征在于与NMUR1明显不同但互补的组织分布,而NMUR1主要存在于外周,而NMUR2在中枢神经系统中含量最高。 神经肽减少啮齿动物食物摄入的能力触发了多种修饰肽配体的设计和合成。 这些配体的目的是开发对肥胖症和糖尿病的治疗可能有益的新型疗法。 大多数化合物要么来源于全长神经介素U序列,要么基于该神经肽的截短直向同源物。 仅开发了一些非肽配体。 这篇综述概述了迄今为止已报道的各种神经介素U类似物和模拟物。
关键词: Neuromedin U,Neuromedin U受体1,Neuromedin U受体2,激动剂,拮抗剂,类似物,拟肽。
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