摘要
肌肽(β-丙氨酰-L-组氨酸)是一种内源性合成的二肽,存在于不同的人体组织中,例如:在肾脏。肌肽被酶血清肌苷酶降解,由CNDP1基因编码。肌肽在肾脏中参与不同的代谢途径。它降低了促炎和纤维化细胞因子的水平,抑制了晚期糖基化终产物的形成,而且还减少了肾小球膜细胞的增殖。肌肽也可以用作过氧化物和羟基的清除剂以及天然的血管紧张素转化酶抑制剂。 这篇综述总结了关于肌肽在肾脏疾病,特别是慢性肾脏疾病,缺血/再灌注引起的急性肾衰竭,糖尿病性肾病以及药物引起的肾毒性中的作用的实验和人体研究结果。讨论了血清肌肽浓度与CNDP1基因中血清肌苷酶活性和多态性之间的相互作用。 肌肽具有肾脏保护特性。它在治疗和预防不同的肾脏疾病,特别是慢性肾脏疾病(具有全球公共卫生问题)方面具有广阔的发展潜力。肌肽在肾脏中的作用的进一步研究可能为肾脏疾病的治疗提供创新和有效的策略。
关键词: 肌肽,血清肌肽酶,CNDP1基因,慢性肾脏病,糖尿病肾病,肾保护。
[http://dx.doi.org/10.1074/jbc.M109.095505] [PMID: 20097752]
[http://dx.doi.org/10.1152/physrev.00039.2012] [PMID: 24137022]
[http://dx.doi.org/10.1007/s00726-015-2045-7] [PMID: 26206726]
[http://dx.doi.org/10.1016/0098-2997(92)90006-L] [PMID: 9765790]
[http://dx.doi.org/10.1111/j.1471-4159.1978.tb07051.x] [PMID: 621500]
[http://dx.doi.org/10.1016/0006-8993(79)91099-0] [PMID: 487087]
[http://dx.doi.org/10.1016/0009-8981(82)90166-8] [PMID: 7116644]
[http://dx.doi.org/10.1074/jbc.M209764200] [PMID: 12473676]
[http://dx.doi.org/10.1007/s00726-013-1476-2] [PMID: 23479117]
[http://dx.doi.org/10.1080/17461391.2018.1444096] [PMID: 29502490]
[http://dx.doi.org/10.1016/j.maturitas.2016.06.002] [PMID: 27344459]
[http://dx.doi.org/10.1007/s00726-016-2208-1] [PMID: 26984320]
[http://dx.doi.org/10.1016/bs.afnr.2017.12.003] [PMID: 29555069]
[http://dx.doi.org/10.1007/s00424-003-1101-4] [PMID: 12905028]
[http://dx.doi.org/10.1007/s00360-016-1044-7] [PMID: 27803975]
[http://dx.doi.org/10.1016/j.ejphar.2005.02.010] [PMID: 15878720]
[http://dx.doi.org/10.1016/j.cyto.2008.02.011] [PMID: 18397832]
[http://dx.doi.org/10.1093/ndt/gfr324] [PMID: 21750159]
[http://dx.doi.org/10.1046/j.1523-1755.2003.00829.x] [PMID: 12631075]
[PMID: 17179517]
[http://dx.doi.org/10.1055/s-0043-100117] [PMID: 28407658]
[http://dx.doi.org/10.1016/S0304-4165(97)00123-2] [PMID: 9545530]
[http://dx.doi.org/10.1016/j.regpep.2008.12.004] [PMID: 19154760]
[http://dx.doi.org/10.1007/s12291-016-0564-y] [PMID: 28149008]
[http://dx.doi.org/10.1177/0960327111404908] [PMID: 21464095]
[http://dx.doi.org/10.1016/S1734-1140(10)70331-5] [PMID: 20885014]
[http://dx.doi.org/10.1007/BF02578242] [PMID: 7968266]
[http://dx.doi.org/10.1093/ageing/29.3.207] [PMID: 10855900]
[http://dx.doi.org/10.2174/0929867054864796] [PMID: 16181134]
[http://dx.doi.org/10.12659/MSM.890528] [PMID: 24614724]
[http://dx.doi.org/10.1021/jf0260242] [PMID: 12617609]
[http://dx.doi.org/10.1016/j.regpep.2014.09.005] [PMID: 25234296]
[http://dx.doi.org/10.1007/s00726-011-1046-4] [PMID: 21833769]
[http://dx.doi.org/10.1111/pedi.12564] [PMID: 28744992]
[http://dx.doi.org/10.1053/j.jrn.2016.08.004] [PMID: 27641823]
[http://dx.doi.org/10.1038/ki.2011.341] [PMID: 21975860]
[http://dx.doi.org/10.1093/ndt/gfm790] [PMID: 18039642]
[http://dx.doi.org/10.1053/j.ackd.2005.02.001] [PMID: 15822056]
[http://dx.doi.org/10.1136/bmjopen-2017-020623] [PMID: 29567852]
[http://dx.doi.org/10.1139/cjpp-2016-0647] [PMID: 28675793]
[http://dx.doi.org/10.1016/j.cbi.2011.03.017] [PMID: 21501601]
[http://dx.doi.org/10.1371/journal.pone.0017971] [PMID: 21423579]
[http://dx.doi.org/10.1111/j.1582-4934.2010.01101.x] [PMID: 20518851]
[http://dx.doi.org/10.1074/jbc.M113.504753] [PMID: 23928303]
[http://dx.doi.org/10.1046/j.1365-2257.1998.00123.x] [PMID: 9777271]
[http://dx.doi.org/10.1111/cei.13119] [PMID: 29453850]
[http://dx.doi.org/10.1016/S0531-5565(98)00056-4] [PMID: 10197726]
[http://dx.doi.org/10.1016/j.bbrc.2004.09.136] [PMID: 15474517]
[http://dx.doi.org/10.1111/j.1474-9726.2006.00266.x] [PMID: 17266680]
[http://dx.doi.org/10.1016/j.mam.2011.10.004] [PMID: 22020113]
[http://dx.doi.org/10.1007/s00726-012-1251-9] [PMID: 22367578]
[http://dx.doi.org/10.1177/153537020322801007] [PMID: 14610252]
[http://dx.doi.org/10.1016/j.ejphar.2003.09.036] [PMID: 14642792]
[http://dx.doi.org/10.1248/bpb.28.361] [PMID: 15684500]
[http://dx.doi.org/10.1124/jpet.106.110122] [PMID: 16916994]
[http://dx.doi.org/10.1159/000331740] [PMID: 21865735]
[http://dx.doi.org/10.1038/ki.2011.250] [PMID: 21814176]
[PMID: 17325631]
[http://dx.doi.org/10.1016/j.cca.2010.10.016] [PMID: 20971102]
[http://dx.doi.org/10.1007/s00125-011-2178-5] [PMID: 21573905]
[http://dx.doi.org/10.1007/s00125-010-1863-0] [PMID: 20711718]
[http://dx.doi.org/10.2337/diabetes.54.8.2320] [PMID: 16046297]
[http://dx.doi.org/10.1007/s10545-017-0099-2] [PMID: 29027595]
[http://dx.doi.org/10.1093/ndt/gfl717] [PMID: 17205963]
[http://dx.doi.org/10.4103/0971-5916.193280] [PMID: 27834323]
[http://dx.doi.org/10.2337/db08-1303] [PMID: 18753673]
[http://dx.doi.org/10.1007/s00439-009-0667-0] [PMID: 19373489]
[http://dx.doi.org/10.1007/s40620-014-0096-6] [PMID: 24756973]
[http://dx.doi.org/10.2337/db09-1377] [PMID: 20332346]
[http://dx.doi.org/10.1016/j.arcmed.2010.07.006] [PMID: 20851293]
[http://dx.doi.org/10.2337/db07-0128] [PMID: 17601991]
[http://dx.doi.org/10.1016/S0140-6736(68)91924-7] [PMID: 4172777]
[http://dx.doi.org/10.1007/s00726-015-2024-z] [PMID: 26081982]
[http://dx.doi.org/10.1080/14756366.2017.1355793] [PMID: 28776438]
[http://dx.doi.org/10.1093/ndt/17.suppl_2.2] [PMID: 11904350]
[http://dx.doi.org/10.1016/j.ymgme.2011.02.010] [PMID: 21393041]
[http://dx.doi.org/10.3109/10520295.2014.913811] [PMID: 24834928]
[http://dx.doi.org/10.1016/0005-2736(94)90201-1] [PMID: 8075140]
[PMID: 23798302]
[http://dx.doi.org/10.1248/bpb.28.361] [PMID: 15684500]
[http://dx.doi.org/10.12659/MSM.905181] [PMID: 29334583]
[http://dx.doi.org/10.1007/s12291-010-0018-x] [PMID: 23105891]
[http://dx.doi.org/10.1177/0960327115597468] [PMID: 26224044]
[http://dx.doi.org/10.2337/db07-0177] [PMID: 17601992]
[http://dx.doi.org/10.1007/s00726-011-1165-y] [PMID: 22120670]
[http://dx.doi.org/10.1038/srep19348] [PMID: 26783107]
[http://dx.doi.org/10.1038/srep44492] [PMID: 28281693]
[http://dx.doi.org/10.1016/j.diabres.2009.06.001] [PMID: 19577318]
[http://dx.doi.org/10.1371/journal.pone.0054064] [PMID: 23342076]
[http://dx.doi.org/10.1111/j.1464-5491.2009.02846.x] [PMID: 19929986]
[http://dx.doi.org/10.1155/2017/9506730] [PMID: 28553654]
[http://dx.doi.org/10.1203/00006450-199702000-00009] [PMID: 9029640]
[http://dx.doi.org/10.1016/S1566-0702(02)00048-6] [PMID: 12132650]
[http://dx.doi.org/10.1152/ajpregu.00275.2004] [PMID: 15498968]
[http://dx.doi.org/10.1016/j.neulet.2006.11.035] [PMID: 17166664]
[http://dx.doi.org/10.1016/j.atherosclerosis.2013.11.068] [PMID: 24468155]
[http://dx.doi.org/10.1016/j.pop.2014.08.008] [PMID: 25439539]
[http://dx.doi.org/10.4102/phcfm.v9i1.1435] [PMID: 29113441]
[http://dx.doi.org/10.1016/j.pcad.2013.10.005] [PMID: 24438733]
[http://dx.doi.org/10.1038/sj.ki.5002586] [PMID: 17928825]
[http://dx.doi.org/10.2337/db07-0177] [PMID: 17601992]
[http://dx.doi.org/10.1016/j.ejphar.2005.02.010] [PMID: 15878720]
[http://dx.doi.org/10.1002/oby.21434] [PMID: 27040154]
[http://dx.doi.org/10.1371/journal.pone.0138646] [PMID: 26406981]
[http://dx.doi.org/10.1038/srep27224] [PMID: 27265207]
[http://dx.doi.org/10.1042/CS20160395]
[http://dx.doi.org/10.1136/bmjopen-2017-017691] [PMID: 28864708]
[http://dx.doi.org/10.1371/journal.pone.0138707] [PMID: 26439389]
[http://dx.doi.org/10.1152/ajpregu.00425.2015] [PMID: 27009050]
[http://dx.doi.org/10.1038/sj.bjc.6602162] [PMID: 15365568]
[http://dx.doi.org/10.1016/j.cell.2012.03.017] [PMID: 22500797]
[http://dx.doi.org/10.7150/jca.8024] [PMID: 24799956]
[http://dx.doi.org/10.1152/ajprenal.00084.2012] [PMID: 22496410]
[http://dx.doi.org/10.1007/s10157-013-0874-9] [PMID: 24129556]
[http://dx.doi.org/10.1515/jpem-2015-0262] [PMID: 27278783]
[http://dx.doi.org/10.1007/s00726-018-2601-z] [PMID: 29922921]
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