Abstract
Microfluidic devices on chip-based systems are becoming increasingly popular, because of many advantages, like low mobile phase consumption and greatly reduced analysis times. The ultimate goal is to design all-including labon- a-chip tools that can be employed in the field and that integrate all elements necessary for an analysis, e.g. one or more separation channels, (multiple) detectors, mixing chambers and sample pretreatment areas. The chip format permits to make any channel pattern, rendering the applications of lab-on-a-chip unlimited. However, overcoming the limitations inherent with the detection systems remains a challenging problem. Whereas UV-detection is predominant in the larger systems, its sensitivity is inadequate due to the minute pathlengths employed in a chip. This review summarizes the shortcomings of UV detection, and discusses some possible solutions. Besides, it presents an overview of the alternative detection methods that have been employed in pharmaceutical and chiral chip analysis, including their positive and negative aspects as well. Finally, the applications reported on the chips are discussed.
Keywords: Detection, Microfluidic device, Lab-on-chip system, Pharmaceutical analysis, Chiral separation
Current Pharmaceutical Analysis
Title: Detection Systems for Microfluidic Devices with a Major Focus on Pharmaceutical and Chiral Analysis
Volume: 5 Issue: 2
Author(s): I. Tanret, D. Mangelings and Y. Vander Heyden
Affiliation:
Keywords: Detection, Microfluidic device, Lab-on-chip system, Pharmaceutical analysis, Chiral separation
Abstract: Microfluidic devices on chip-based systems are becoming increasingly popular, because of many advantages, like low mobile phase consumption and greatly reduced analysis times. The ultimate goal is to design all-including labon- a-chip tools that can be employed in the field and that integrate all elements necessary for an analysis, e.g. one or more separation channels, (multiple) detectors, mixing chambers and sample pretreatment areas. The chip format permits to make any channel pattern, rendering the applications of lab-on-a-chip unlimited. However, overcoming the limitations inherent with the detection systems remains a challenging problem. Whereas UV-detection is predominant in the larger systems, its sensitivity is inadequate due to the minute pathlengths employed in a chip. This review summarizes the shortcomings of UV detection, and discusses some possible solutions. Besides, it presents an overview of the alternative detection methods that have been employed in pharmaceutical and chiral chip analysis, including their positive and negative aspects as well. Finally, the applications reported on the chips are discussed.
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Cite this article as:
Tanret I., Mangelings D. and Heyden Vander Y., Detection Systems for Microfluidic Devices with a Major Focus on Pharmaceutical and Chiral Analysis, Current Pharmaceutical Analysis 2009; 5 (2) . https://dx.doi.org/10.2174/157341209788172951
DOI https://dx.doi.org/10.2174/157341209788172951 |
Print ISSN 1573-4129 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-676X |
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