Title:A Decennial Update on the Applications of Trifluroacetic Acid
Volume: 21
Issue: 4
Author(s): Mohammed Mujahid Alam, Ravi Varala*Vittal Seema
Affiliation:
- Scrips Pharma,
Mallapur, Hyderabad, 500076, Telangana, India
Keywords:
Organic synthesis, reagent, solvent, trifluoroacetic acid (TFA), trifluoromethyl group, catalyst.
Abstract: Since its discovery at the beginning of the 20th century, trifluoroacetic acid, commonly
known as TFA, has seen extensive application in organic synthesis both as a solvent and as a catalyst/
reagent. TFA can be used to facilitate a wide variety of chemical transformations, including rearrangements,
functional group deprotections, condensations, hydroarylations and trifluoroalkylations,
among others. The decennial mini-review examines key TFA synthetic applications from the middle
of 2013 to the present, providing the organic chemistry research community with an opportunity to
delve deeply into the numerous and varied applications of this strong acid, water-miscible, and low
boiling point reagent.