Evaluation of the Effect of Chelating Arms and Carrier Agents on t he
Radiotoxicity of TAT Agents

Soghra      Farzipour; Zahra      Shaghaghi; Marziyeh      Raeispour; Maryam      Alvandi; Fatemeh      Jalali; Amirhossein      Yazdi
doi:10.2174/1874471015666220510161047
Abstract

Targeted Alpha Therapy (TAT) is considered an evolving therapeutic option for cancer cells, in which a carrier molecule labeling with an α-emitter radionuclide make the bond with a specific functional or molecular target. α-particles with high Linear Energy Transfer (LET) own an increased Relative Biological Effectiveness (RBE) over common β-emitting radionuclides. Normal tissue toxicity due to non-specific uptake of mother and daughter α-emitter radionuclides seems to be the main conflict in clinical applications. The present survey reviews the available preclinical and clinical studies investigating healthy tissue toxicity of the applicable α -emitters and particular strategies proposed for optimizing targeted alpha therapy success in cancer patients.
Keywords: Targeted alpha therapy, radiotoxicity, radiobiology, dosimetry, chelator, carrier.
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Graphical Abstract

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DOI https://dx.doi.org/10.2174/1874471015666220510161047	Print ISSN 1874-4710
Publisher Name Bentham Science Publisher	Online ISSN 1874-4729
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