Abstract
Background: 2-oxazolines and 2-thiazolines are important heterocycles due to their extensive applications in chemistry, biochemistry, and pharmacology. Most of the precedent methods for preparing these heterocycles involve one or more drawbacks, including harsh reaction conditions, long reaction times, low yields of products, high temperature, and toxic solvents.
Objective: The aim of this study was to develop a new and eco-efficient method for the preparation of 2-oxazolines and 2-thiazolines.
Methods: Amino alcohols were condensed with nitriles in a sealed tube under solvent-free and metal- free conditions.
Results: Our procedure appears to be highly eco-efficient and promotes quantitative access to 2-oxazolines and 2-thiazolines using simple and minimum manipulation.
Conclusion: This simple approach allows high conversion for different nitriles yielded from 78 to 99% and easy isolation of the targeted products without further purification. To the best of our knowledge, our procedure is the most efficient and fast method reported to date in terms of chemical yields, number of steps, and atom economy.
Keywords: Green chemistry, 2-thiazolines, 2-oxazolines, sealed tube, solvent-free, metal-free.
Current Organocatalysis
Title:Efficacious One-pot Synthesis of 2-thiazolines and 2-oxazolines Under Solvent and Metal-Free Conditions
Volume: 8 Issue: 3
Author(s): Wassima Talbi , Jamil Kraiem*, Yakdhane Kacem , Jérôme Marrot and Sylvain Marque *
Affiliation:
- Laboratoire de Developpement Chimique, Galenique et Pharmacologique des Medicaments (LR12ES09), Universite de Monastir, Faculte de Pharmacie de Monastir, Rue Avicenne, 5000, Monastir,Tunisia
- Universite Versailles Saint- Quentin-en-Yvelines, Institut Lavoisier de Versailles (ILV), UMR CNRS 8180, 45 avenue des Etats-Unis, 78 035 Versailles Cedex,France
Keywords: Green chemistry, 2-thiazolines, 2-oxazolines, sealed tube, solvent-free, metal-free.
Abstract:
Background: 2-oxazolines and 2-thiazolines are important heterocycles due to their extensive applications in chemistry, biochemistry, and pharmacology. Most of the precedent methods for preparing these heterocycles involve one or more drawbacks, including harsh reaction conditions, long reaction times, low yields of products, high temperature, and toxic solvents.
Objective: The aim of this study was to develop a new and eco-efficient method for the preparation of 2-oxazolines and 2-thiazolines.
Methods: Amino alcohols were condensed with nitriles in a sealed tube under solvent-free and metal- free conditions.
Results: Our procedure appears to be highly eco-efficient and promotes quantitative access to 2-oxazolines and 2-thiazolines using simple and minimum manipulation.
Conclusion: This simple approach allows high conversion for different nitriles yielded from 78 to 99% and easy isolation of the targeted products without further purification. To the best of our knowledge, our procedure is the most efficient and fast method reported to date in terms of chemical yields, number of steps, and atom economy.
Export Options
About this article
Cite this article as:
Talbi Wassima , Kraiem Jamil *, Kacem Yakdhane , Marrot Jérôme and Marque Sylvain *, Efficacious One-pot Synthesis of 2-thiazolines and 2-oxazolines Under Solvent and Metal-Free Conditions, Current Organocatalysis 2021; 8 (3) . https://dx.doi.org/10.2174/2213337208666210402130444
DOI https://dx.doi.org/10.2174/2213337208666210402130444 |
Print ISSN 2213-3372 |
Publisher Name Bentham Science Publisher |
Online ISSN 2213-3380 |
Call for Papers in Thematic Issues
Impact of Organocatalysis on Homogeneous and Heterogeneous Catalytic Organic Synthesis: Recent Advances and Developments
Catalysis is vital in improving the reaction time, conversion, selectivity, and yield of organic and biological reactions. Heterogeneous and homogeneous catalysis have developed many types of catalysts to perform different organic and industrial reactions. In recent decades, researchers have tried to perform the reactions in a greener and more sustainable ...read more
Related Journals
![](/images/wayfinder.jpg)
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Natural-based Hydrogels: A Journey from Simple to Smart Networks for Medical Examination
Current Medicinal Chemistry Therapeutic Potential and Prospects of L-arginine in Various Diseases and its Clinical Intervention
Current Drug Therapy A New and Convenient Synthesis of the Boceprevir P1 Fragment, β-amino-α-Hydroxy Amide
Letters in Organic Chemistry Cell Microencapsulation Implants into the Central Nervous System
Recent Patents on Nanomedicine Copper Complexes of 8-Aminoquinoline and Uracils as Novel Aromatase Inhibitors
Letters in Drug Design & Discovery The Challenge of Exploiting ABCG2 in the Clinic
Current Pharmaceutical Biotechnology Electrocatalytic Determination of 6-Mercaptopurine Using Multiwall Carbon Nanotubes Paste Electrode in the Presence of Methyldopa
Current Nanoscience G-Quadruplex as Signal Transducer for Biorecognition Events
Current Pharmaceutical Design Biodistribution and Tumor Targeting of Indium and Iodine-labeled Shiga Toxin B-Subunit
Current Radiopharmaceuticals Recent Advances in Radiation Therapy of Cancer Cells: A Step towards an Experimental and Systems Biology Framework
Current Radiopharmaceuticals The Pros and the Cons for the Use of Silybin-Rich Oral Formulations in Treatment of Liver Damage (NAFLD in Particular)
Current Medicinal Chemistry Mitochondrial Genomics and Proteomics
Current Genomics Antioxidant Constituents from the Stem and Leaf of Helicteres hirsuta Loureiro
The Natural Products Journal Interactions of Dietary Flavonoids with Proteins: Insights from Fluorescence Spectroscopy and Other Related Biophysical Studies
Current Drug Metabolism In Vitro Anticancer Evaluation of Some Synthesized 2H-Quinolinone and Halogenated 2H-Quinolinone Derivatives as Therapeutic Agents
Anti-Cancer Agents in Medicinal Chemistry A Novel Information Theoretic Approach to Gene Selection for Cancer Classification Using Microarray Data
Current Bioinformatics Pharmaceutical and Biomedical Potential of PEGylated Dendrimers
Current Pharmaceutical Design Learning from Multiple Classifier Systems: Perspectives for Improving Decision Making of QSAR Models in Medicinal Chemistry
Current Topics in Medicinal Chemistry Biomarker Discovery in Clinical Proteomics: Strategies for Exposing Low Abundant Proteins
Current Proteomics Co-administration of Saffron and Chamomile Give Additive Effects of Antidiabetic and Antioxidant Activity with <i>In vivo</i> Augmentation of Brain BDNF, Acetylcholine Levels and Cognitive Functions in Streptozotocininduced Diabetic Rats
Current Psychopharmacology