Abstract
In the past few decades, drug-eluting stents have made significant contributions to the treatment of coronary heart disease. However, due to the delayed healing of endothelial injuries caused by antiproliferative drugs and insufficient biocompatibility of vascular stent materials, late in-stent thrombosis and restenosis remain major challenges. Surface modification of cardiovascular materials to construct a biological functional layer that can regulate the behavior of blood and vascular cells is an effective way to improve the clinical performance of vascular stents. This paper reviewed the common methods of surface bio-functional modification of cardiovascular materials and especially proposed that take advantage of the new concept of precision medicine, as well as the precise and orderly regulation properties of cardiovascular disease-related gene fragments on vascular biological response behavior, the construction of gene-eluting stents which can in-situ regulate vascular intimal repair at the molecular and genetic level will become an important research direction in the future.
Keywords: Stent, surface modification, gene delivery, restenosis, endothelialization, precision medicine.
Current Drug Delivery
Title:Progress on Precise Regulation of Vascular Intimal Repair by a Surface Coating of Vascular Stent
Volume: 18 Issue: 7
Author(s): Shihui Liu , Junchao Zhi, Shijie Li, Zhuoyue Song, Tao Gong , Changjiang Pan, Chunzhi Tang, Nenggui Xu*Tao Liu*
Affiliation:
- Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006,China
- Medical College of Acu-Moxi and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou 510006,China
Keywords: Stent, surface modification, gene delivery, restenosis, endothelialization, precision medicine.
Abstract: In the past few decades, drug-eluting stents have made significant contributions to the treatment of coronary heart disease. However, due to the delayed healing of endothelial injuries caused by antiproliferative drugs and insufficient biocompatibility of vascular stent materials, late in-stent thrombosis and restenosis remain major challenges. Surface modification of cardiovascular materials to construct a biological functional layer that can regulate the behavior of blood and vascular cells is an effective way to improve the clinical performance of vascular stents. This paper reviewed the common methods of surface bio-functional modification of cardiovascular materials and especially proposed that take advantage of the new concept of precision medicine, as well as the precise and orderly regulation properties of cardiovascular disease-related gene fragments on vascular biological response behavior, the construction of gene-eluting stents which can in-situ regulate vascular intimal repair at the molecular and genetic level will become an important research direction in the future.
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Cite this article as:
Liu Shihui , Zhi Junchao, Li Shijie, Song Zhuoyue , Gong Tao, Pan Changjiang , Tang Chunzhi, Xu Nenggui*, Liu Tao *, Progress on Precise Regulation of Vascular Intimal Repair by a Surface Coating of Vascular Stent, Current Drug Delivery 2021; 18 (7) . https://dx.doi.org/10.2174/1567201818666210212100633
DOI https://dx.doi.org/10.2174/1567201818666210212100633 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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