Abstract
The recent increased interest in orodispersible films (ODF) stems from their ideal potential to circumvent several pharmacotherapy-related problems, such as improved medication compliance and adherence, especially in children, elderly and uncooperative patients. Their administration is well accepted by the majority of patients because ODF dissolve upon contact with the saliva in the oral cavity without the need for water intake. ODF application in personalized pharmacotherapy is currently being exploited. Moreover, innovative preparation methods and characterization technologies have been evolving in recent years, highlighting a promising future both from the technological and clinical standpoints. However, the key obstacles to the attainment of full potential of ODF in the pharmaceutical field is the lack of harmonized and well-defined quality characterization procedures, standard evaluation parameters, guidance on appropriate final product properties and specifications. This review provides an appraisal on the ODF characterization methods from slurries to the finished medicinal products with a specific focus on the technologies suitable for identification, quantification, and quality evaluation of extemporaneously prepared ODF on small batches in individualized pharmacotherapy. Generally, there is a paradigm shift from the use of the conventional quality evaluation tools and/or protocols for oral solid dosage forms to characterize ODF to more specific equipment and procedures that suit the peculiarities of the ODF.
Keywords: Orodispersible films, non-destructive assay, quality control, mechanical properties, personalized therapy, therapy pharmaco.
Current Drug Delivery
Title:Trends in the Characterization Methods of Orodispersible Films
Volume: 18 Issue: 7
Author(s): Garba M. Khalid, Francesca Selmin, Umberto M. Musazzi, Chiara G.M. Gennari, Paola Minghetti and Francesco Cilurzo*
Affiliation:
- Department of Pharmaceutical Sciences, Universita degli Studi di Milano, 20133 Milan,Italy
Keywords: Orodispersible films, non-destructive assay, quality control, mechanical properties, personalized therapy, therapy pharmaco.
Abstract: The recent increased interest in orodispersible films (ODF) stems from their ideal potential to circumvent several pharmacotherapy-related problems, such as improved medication compliance and adherence, especially in children, elderly and uncooperative patients. Their administration is well accepted by the majority of patients because ODF dissolve upon contact with the saliva in the oral cavity without the need for water intake. ODF application in personalized pharmacotherapy is currently being exploited. Moreover, innovative preparation methods and characterization technologies have been evolving in recent years, highlighting a promising future both from the technological and clinical standpoints. However, the key obstacles to the attainment of full potential of ODF in the pharmaceutical field is the lack of harmonized and well-defined quality characterization procedures, standard evaluation parameters, guidance on appropriate final product properties and specifications. This review provides an appraisal on the ODF characterization methods from slurries to the finished medicinal products with a specific focus on the technologies suitable for identification, quantification, and quality evaluation of extemporaneously prepared ODF on small batches in individualized pharmacotherapy. Generally, there is a paradigm shift from the use of the conventional quality evaluation tools and/or protocols for oral solid dosage forms to characterize ODF to more specific equipment and procedures that suit the peculiarities of the ODF.
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Cite this article as:
Khalid M. Garba , Selmin Francesca , Musazzi M. Umberto , Gennari G.M. Chiara , Minghetti Paola and Cilurzo Francesco *, Trends in the Characterization Methods of Orodispersible Films, Current Drug Delivery 2021; 18 (7) . https://dx.doi.org/10.2174/1567201818999201210212557
DOI https://dx.doi.org/10.2174/1567201818999201210212557 |
Print ISSN 1567-2018 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5704 |
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