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Endocrine, Metabolic & Immune Disorders - Drug Targets

Formerly: Current Drug Targets - Immune, Endocrine & Metabolic Disorders

Volume 22, 14 Issues, 2022
ISSN: 2212-3873 (Online)
ISSN: 1871-5303 (Print)
This journal supports open access

Aims & Scope

This journal is devoted to full-length/ mini reviews and original articles of experimental and clinical studies in the field of endocrine, metabolic, and immune disorders. Specific emphasis is placed on humoral and cellular targets for natural, synthetic, and genetically engineered drugs that enhance or impair endocrine, metabolic, and immune parameters and functions. Moreover, the topics related to the effects of food components and/or nutraceuticals on the endocrine-metabolic-immune axis and on microbioma composition are welcome.

Endocrine, Metabolic & Immune Disorders - Drug Targets

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Volume 22

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Number 1



Perspective Article

An Alternative “Trojan Horse” Hypothesis for COVID-19: Immune Deficiency of IL-10 and SARS-CoV-2 Biology

, 22(1): 1 - 5

Mario Giosuè Balzanelli, Pietro Distratis, Sergey K. Aityan, Felice Amatulli, Orazio Catucci, Angelo Cefalo, Antonia De Michele, Gianna Dipalma, Francesco Inchingolo, Rita Lazzaro, Kieu Cao Diem Nguyen, Davide Palazzo, Marilina Tampoia, Van Hung Pham, Luigi Santacroce* and Ciro Gargiulo Isacco


DOI: 10.2174/1871530321666210127141945





Research Article

Dietary Intakes and Food Habits of Wheelchair Basketball Athletes Compared to Gym Attendees and Individuals who do not Practice Sport Activity

, 22(1): 38 - 48

Elisabetta Toti, Valentina Cavedon, Anna Raguzzini, Anna Lucia Fedullo, Chiara Milanese, Elisabetta Bernardi, Sheila Bellito, Marco Bernardi, Tommaso Sciarra and Ilaria Peluso*


DOI: 10.2174/1871530321666210208213046


Research Article

Appraisal of Anti-Arthritic and Anti-Inflammatory Potential of Folkloric Medicinal Plant <i>Peganum harmala</i>

, 22(1): 49 - 63

Muhammad Furqan Akhtar*, Syed Ahmad Raza, Ammara Saleem*, Irfan Hamid, Mirza Muhammad Faran Ashraf Baig, Ali Sharif, Kashif Sohail, Zeeshan Javaid, Uzma Saleem and Azhar Rasul


DOI: 10.2174/1871530321666210208211310


Research Article




Articles Ahead of Print


Subclinical Hypothyroidism in Patients with Diabetic Retinopathy: Role of Vascular Endothelial Growth Factor


Amr Ali El-Sehrawy*, Enas M . Elkhamisy, Amani E. Badawi, Heba A . Elshahawy, Eman Elsayed, Nehal Tharwat Mohammed and Mervat M El-Eshmawy


DOI: 10.2174/1871530321666210809151258
View Abstract View on PubMed




Combined Treatment with Laser Ablation and Tyrosine-Kinase Inhibitor as A Novel Multimodality Approach to Locally Advanced Thyroid Cancer: A Case Report


Agnese Persichetti, Salvatore Monti, Carmela Coccaro, Federica Presciuttini, Maria Grazia Deiana, Giancarlo Bizzarri, Antonio Bianchini, Vincenzo Triggiani, Enrico Papini* and Rinaldo Guglielmi


DOI: 10.2174/1871530321666210830093522
View Abstract View on PubMed





Eating Disorders and Type 1 Diabetes: A Perspective


Simonetta Marucci*, Giulia De Iaco, Giuseppe Lisco, Francesco Mariano, Vito Angelo Giagulli, Edoardo Guastamacchia, Giovanni De Pergola and Vincenzo Triggiani


DOI: 10.2174/1871530321666211109152353
View Abstract View on PubMed


Menstrual Disorders Related to Eating Disorders


Walter Milano, Paola Ambrosio, Francesca Carizzone, Valeria De Biasio, Maria Gabriella Foia, Biancamaria Saetta, Maria Francesca Milano and Anna Capasso*


DOI: 10.2174/1871530321666210625145345
View Abstract View on PubMed


Abstracts Ahead of Print

Neuroendocrine modulation of food intake and eating behavior


Michele Iovino, Tullio Messana, Giuseppe Lisco, Francesco Mariano, Vito Angelo Giagulli, Edoardo Guastamacchia, Giovanni De Pergola and Vincenzo Triggiani*


DOI: 10.2174/1871530322666220127114326
View Abstract


Immunological and Metabolic Alterations in Esophageal Cancer


Mary Mikhael, Bilal Pasha, Harleen Chela, Veysel Tahan* and Ebubekir Daglilar


DOI: 10.2174/1871530322666220127113752
View Abstract



Vitamin D and Omega-3 Polyunsaturated Fatty Acids in Type 1 Diabetes modulation


Thais Sibioni Berti Bastos*, Tárcio Teodoro Braga and Mariana Rodrigues Davanso


DOI: 10.2174/1871530322666220103114450
View Abstract



A multi-professional approach for transition of care at discharge in hyperglycemic inpatients with covid-19: a single center study


Elena Castellano*, Donatella Gaviglio, Micaela Pellegrino, Laura Gianotti, Giampaolo Magro, Francesco Tassone, Claudia Baffoni, Renza Sibbono, Roberto Attanasio, Alberto Boriano and Giorgio Borretta


DOI: 10.2174/1871530322666220104100944
View Abstract



Immunometabolism in bladder cancer microenvironment


Mohammad Javad Fattahi, Mohammad Reza Haghshenas and Abbas Ghaderi*


DOI: 10.2174/1871530322666220104103905
View Abstract


The pathogenic role of foam cells in atherogenesis: Do they represent novel therapeutic targets?


Lisco Giuseppe, Giagulli Vito Angelo, De Pergola Giovanni, Guastamacchia Edoardo, Jirillo Emilio* and Triggiani Vincenzo


DOI: 10.2174/1871530322666220107114313
View Abstract



Published Contents

Editor's Choice



Can Cytokines be used as an Activation Marker in Rheumatoid Arthritis?

, 2021; 21(8): 1459 - 1465

Fatih Öner Kaya, Yeşim Ceylan, Belkız Öngen İpek, Zeynep Güneş Özünal, Gülbüz Sezgin and Selim Nalbant*


DOI: 10.2174/1871530320666201019115030



Benfotiamine Reduces Dendritic Cell Inflammatory Potency

, 2021; 21(7): 1344 - 1351

Neda Djedovic, Iva Božić, Đorđe Miljković* and Irena Lavrnja


DOI: 10.2174/1871530320999200905114135



Acute Versus Chronic Administration of Calcineurin-Inhibitors Differentially Affect T-Cell Function

, 2021; 21(6): 1083 - 1089

Julia Kirchhof, Benjamin Wilde*, Justine Schmidt, Nils Mülling, Liubov Petrakova, Alexandra Brinkhoff, Manfred Schedlowski and Oliver Witzke


DOI: 10.2174/1871530320999200831161710



The Effects of Pemafibrate in Japanese Patients with Type 2 Diabetes Receiving HMG-CoA Reductase Inhibitors

, 2021; 21(5): 919 - 924

Masataka Kusunoki*, Takahiko Sakazaki, Kazuhiko Tsutsumi, Tetsuro Miyata and Yoshiharu Oshida


DOI: 10.2174/1871530320999200818135553



Downregulation of miR-140 is Correlated with Poor Prognosis and Progression of Thyroid Cancer

, 2021; 21(4): 749 - 755

Qianqian Yu, Wenhai Sun, Hui Hua, Yulian Chi, Xiaomin Liu, Anbing Dong, Yinghe Sun, Jianhua Zhang and Ge Guan*


DOI: 10.2174/1871530320666200724180742



T Cell Proliferative Responses and IgG Antibodies to β2GPI in Patients with Diabetes and Atherosclerosis

, 2021; 21(3): 495 - 503

Mohammad R. Monjezi, Hamed Fouladseresht, Shirin Farjadian, Behrouz Gharesi-Fard, Shahdad Khosropanah and Mehrnoosh Doroudchi*


DOI: 10.2174/1871530320666200505115850



Positive Correlation between Circulating Fetuin-A and Severity of Coronary Artery Disease in Men

, 2021; 21(2): 338 - 344

Reza Afrisham, Maliheh Paknejad, Davod Ilbeigi, Sahar Sadegh-Nejadi, Sattar Gorgani-Firuzjaee* and Mahmoud Vahidi*


DOI: 10.2174/1871530320666200601164253




Open Access Articles

The Skeletal Effects of Gonadotropin-Releasing Hormone Antagonists: A Concise Review

, 2021; 21(10): 1713 - 1720

Nur-Vaizura Mohamad, Soelaiman Ima-Nirwana and Kok-Yong Chin*




How Much Vitamin D is Too Much? A Case Report and Review of the Literature

, 2021; 21(9): 1653 - 1659

Sara De Vincentis*, Antonino Russo, Marta Milazzo, Amedeo Lonardo, Maria C. De Santis, Vincenzo Rochira, Manuela Simoni and Bruno Madeo




False Positive of <sup>68</sup>Ga-DOTATATE PET-CT in a Paraganglioma

, 2021; 21(7): 1352 - 1355

Benedetta Zampetti, Roberto Attanasio*, Marco Boniardi and Renato Cozzi




Effects of a Low Carb Diet and Whey Proteins on Anthropometric, Hematochemical, and Cardiovascular Parameters in Subjects with Obesity

, 2020; 20(10): 1719 - 1725

Giovanni De Pergola*, Roberta Zupo, Luisa Lampignano, Silvia Paradiso, Isanna Murro, Annagrazia Cecere, Nicola Bartolomeo, Marco M. Ciccone, Gianluigi Giannelli and Vincenzo Triggiani





The Association between Peripheral Blood Cells and the Frailty Syndrome in Patients with Cardiovascular Diseases

, 2020; 20(9): 1419 - 1433

Constantin Bodolea, Elisabeta I. Hiriscau*, Elena-Cristina Buzdugan, Alin I. Grosu, Laurențiu Stoicescu, Ștefan Vesa and Omar Cauli




Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 2: Therapeutic Issues

, 2020; 20(8): 1144 - 1155

Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson




Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Acromegaly - Part 1: Diagnostic and Clinical Issues

, 2020; 20(8): 1133 - 1143

Renato Cozzi*, Maria R. Ambrosio, Roberto Attanasio, Alessandro Bozzao, Laura De Marinis, Ernesto De Menis, Edoardo Guastamacchia, Andrea Lania, Giovanni Lasio, Francesco Logoluso, Pietro Maffei, Maurizio Poggi, Vincenzo Toscano, Michele Zini, Philippe Chanson and Laurence Katznelson




Exercise and Stevia Rebaudiana (R) Extracts Attenuate Diabetic Cardiomyopathy in Type 2 Diabetic Rats: Possible Underlying Mechanisms

, 2020; 20(7): 1117 - 1132

Abdelaziz M. Hussein*, Elsayed A. Eid, Ismaeel Bin-Jaliah, Medhat Taha and Lashin S. Lashin




Insulin Resistance in Apolipoprotein M Knockout Mice is Mediated by the Protein Kinase Akt Signaling Pathway

, 2020; 20(5): 771 - 780

Shuang Yao, Jun Zhang, Yuxia Zhan, Yuanping Shi, Yang Yu, Lu Zheng, Ning Xu* and Guanghua Luo*




Future Perspective of Diabetic Animal Models

, 2020; 20(1): 25 - 38

Shashank Pandey and Magdalena C. Dvorakova*




Pioglitazone Therapy and Fractures: Systematic Review and Meta- Analysis

, 2018; 18(5): 502 - 507

Velichka Pavlova*, Elena Filipova, Katya Uzunova, Krassimir Kalinov and Toni Vekov




Italian Association of Clinical Endocrinologists (AME) and Italian AACE Chapter Position Statement for Clinical Practice: Assessment of Response to Treatment and Follow-Up in Gastroenteropancreatic Neuroendocrine Neoplasms

, 2018; 18(5): 419 - 449

Franco Grimaldi*, Nicola Fazio*, Roberto Attanasio, Andrea Frasoldati, Enrico Papini, Nadia Cremonini, Maria V. Davi, Luigi Funicelli, Sara Massironi, Francesca Spada, Vincenzo Toscano, Annibale Versari, Michele Zini, Massimo Falconi and Kjell Oberg




Shift from Levothyroxine Tablets to Liquid Formulation at Breakfast Improves Quality of Life of Hypothyroid Patients

, 2018; 18(3): 235 - 240

Rinaldo Guglielmi, Franco Grimaldi, Roberto Negro, Andrea Frasoldati, Irene Misischi, Filomena Graziano, Claudia Cipri, Edoardo Guastamacchia, Vincenzo Triggiani* and Enrico Papini




GH Supplementation Effects on Cardiovascular Risk in GH Deficient Adult Patients: A Systematic Review and Meta-analysis

, 2017; 17(4): 285 - 296

Vito A. Giagulli*, Marco Castellana, Raffaella Perrone, Edoardo Guastamacchia, Massimo Iacoviello and Vincenzo Triggiani





Most Cited Articles


Research Article

Probiotics efficacy on oxidative stress values in inflammatory bowel disease: A randomized double-blinded placebo-controlled pilot study

, 2019; 19(3): 373-381.

Andrea Ballini, Luigi Santacroce*, Stefania Cantore, Lucrezia Bottalico, Gianna Dipalma, Skender Topi, Rajiv Saini, Danila De Vito and Francesco Inchingolo


DOI: 10.2174/1871530319666181221150352



Research Article

Hypoglycemic and hypolipemic effects of a new lecithin formulation of bergamot polyphenolic fraction: A double blind, randomized, placebo- controlled study

, 2019; 19(2): 136-143.

Vincenzo Mollace*, Miriam Scicchitano, Sara Paone, Francesca Casale, Carla Calandruccio, Micaela Gliozzi, Vincenzo Musolino, Cristina Carresi, Jessica Maiuolo, Saverio Nucera, Antonella Riva, Pietro Allegrini, Massimo Ronchi, Giovanna Petrangolini and Ezio Bombardelli


DOI: 10.2174/1871530319666181203151513


Review Article

BPA and nutraceuticals, simultaneous effects on endocrine functions

, 2019; 19(5): 594-604.

Stefania D'Angelo, Marika Scafuro and Rosaria Meccariello*


DOI: 10.2174/1871530319666190101120119


Clinical Trial

The neuromodulatory effects of ω-3 fatty acids and nano-curcumin on the COX-2/ iNOS network in migraines: A clinical trial study from gene expression to clinical symptoms

, 2019; 19(6): 874-884.

Mina Abdolahi, Arash Jafarieh, Payam Sarraf, Mohsen Sedighiyan, Abolghasem Yousefi, Abbas Tafakhori, Hamed Abdollahi, Farahnaz Salehinia and Mahmoud Djalali*


DOI: 10.2174/1871530319666190212170140


Research Article

Evaluation of TG-HDL ratio instead of HOMA ratio as insulin resistance marker in overweight and children with obesity

, 2019; 19(5): 676-682.

Eman G. Behiry*, Nazih Mohamed El Nady, Omima M. AbdEl Haie, May Kamel Mattar and Amira Magdy


DOI: 10.2174/1871530319666190121123535


Research Article

Predictors for fibrosis regression in chronic HCV patients after the treatment with DAAS: Results of a real-world cohort study

, 2020; 20(1): 104-111.

Hanan Soliman, Dina Ziada, Marwa Salama, Manal Hamisa, Rehab Badawi, Nehad Hawash, Amal Selim and Sherief Abd-Elsalam*


DOI: 10.2174/1871530319666190826150344


General Research Article

25 hydroxyvitamin D levels are negatively and independently associated with fat mass in a cohort of healthy overweight and obese subjects

, 2019; 19(6): 838-844.

Giovanni De Pergola*, Tommaso Martino, Roberta Zupo, Domenico Caccavo, Claudio Pecorella, Silvia Paradiso, Franco Silvestris and Vincenzo Triggiani


DOI: 10.2174/1871530319666190122094039


Research Article

Anti-cancerous effect of rutin against HPV-C33A cervical cancer cells via g0/g1 cell cycle arrest and apoptotic induction

, 2020; 20(3): 409-418.

Fahad Khan, Pratibha Pandey*, Tarun K. Upadhyay, Asif Jafri, Niraj K. Jha, Rashmi Mishra and Vineeta Singh


DOI: 10.2174/1871530319666190806122257


General Research Article

Elucidation of the chemopreventive role of stigmasterol against Jab1 in gall bladder carcinoma

, 2019; 19(6): 826-837.

Pratibha Pandey, Preeti Bajpai*, Mohammad H. Siddiqui, Uzma Sayyed, Rohit Tiwari, Rafia Shekh, Kumudesh Mishra and V.K. Kapoor


DOI: 10.2174/1871530319666190206124120


Review Article (Mini-Review)

Quality of life in individuals with diabetic foot syndrome

, 2020; 20(9): 1365-1372.

Emmanuel Navarro-Flores and Omar Cauli*


DOI: 10.2174/1871530320666200128154036



Research Article

Overexpression of hepassocin in diabetic patients with nonalcoholic fatty liver disease may facilitate increased hepatic lipid accumulation

, 2019; 19(2): 185-188.

Ghada Abdelmoemen, Samy Abdelkader Khodeir, Ahmed Nabil Zaki, Maha Kassab, Sabry Abou-Saif and Sherief Abd-Elsalam*


DOI: 10.2174/1871530318666180716100543


Research Article

Sex-specific association between serum uric acid and elevated alanine aminotransferase in a military cohort: The chief study

, 2019; 19(3): 333-340.

Jia-Wei Lin, Kun-Zhe Tsai, Kai-Wen Chen, Fang-Ying Su, Yi-Hwei Li, Yen-Po Lin, Chih-Lu Han, Felicia Lin, Yu-Kai Lin, Chung-Bao Hsieh and Gen-Min Lin*


DOI: 10.2174/1871530319666181129163802



Most Accessed Articles



Negative Correlation between Neuregulin-4 and IL-9 Serum Levels in Patients with Coronary Artery Disease

, 2021; 21(11): 2068-2074.

Hossein Farshidi, Nadereh Naderi, Hossein Montazerghaem, Narges Farshidi and Mahsa Rahimzadeh*


DOI: 10.2174/1871530321666210119115527



Post-Exercise Ketosis, Salivary Uric Acid and Interleukin-6 after a Simulated Wheelchair Basketball Match

, 2021; 21(11): 2055-2062.

Anna Raguzzini, Elisabetta Toti, Marco Bernardi, Fabio Castellucci, Valentina Cavedon, Anna Lucia Fedullo, Chiara Milanese, Tommaso Sciarra and Ilaria Peluso*


DOI: 10.2174/1871530321999210111202724





Ethanol Extract of Achillea fragrantissima Enhances Angiogenesis through Stimulation of VEGF Production

, 2021; 21(11): 2035-2042.

Hana M. Hammad*, Amer Imraish, Maysa Al-Hussaini, Malek Zihlif, Amani A. Harb, Tuqa M. Abu Thiab, Zainab Lafi, Zeyad D. Nassar and Fatma U. Afifi


DOI: 10.2174/1871530321666201230113018


Renal Alterations Induced by Chronic Exposure to Therapeutic Doses of Antihypercholestremic Atorvastatin

, 2021; 21(11): 2043-2054.

Amin Al-Doaiss, Yazun Jarrar, Ali Shati, Mohammad Alfaifi, Mohammed Al-Kahtani and Bashir Jarrar*


DOI: 10.2174/1871530321666210106105059



Thyroid Cancer and Nodules in Graves’ Disease: A Single Center Experience

, 2021; 21(11): 2028-2034.

Claudio Casella, Riccardo Morandi*, Apollonia Verrengia, Alessandro Galani, Sarah Molfino, Dhimiter Cuka, Giacomo Groppo, Carlo Cappelli and Nazario Portolani


DOI: 10.2174/1871530321666201230111911


The Role of Nutrition During the COVID-19 Pandemic: What We Know

, 2021; 21(11): 1982-1992.

Elsa Vitale, Manrico Magrone, Vito Galatola and Thea Magrone*


DOI: 10.2174/1871530321666210114154401



UCP2 and CFH Gene Variants with Genetic Susceptibility to Schizophrenia in Turkish Population

, 2021; 21(11): 2084-2089.

Ayse Feyda Nursal*, Pinar Cetinay Aydin, Mustafa Pehlivan, Ulgen Sever and Sacide Pehlivan


DOI: 10.2174/1871530320999201113103730




Editor-in-Chief

graphic
Emilio Jirillo
Department of Basic Medical Sciences Neuroscience and Sensory Organs
University of Bari “Aldo Moro”
Bari
(Italy)
Biography
View Full Editorial Board

COPE Compliant

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Journal History

Current Drug Targets - Immune, Endocrine & Metabolic Disorders was launched in 2001 and later renamed in 2006 as Endocrine, Metabolic & Immune Disorders - Drug Targets.

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