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Drug Metabolism Letters

Continued as: Drug Metabolism and Bioanalysis Letters

Volume 15, 3 Issues, 2022
ISSN: 1874-0758 (Online)
ISSN: 1872-3128 (Print)
This journal supports open access

Aims & Scope

Drug Metabolism Letters publishes letters, original research articles, mini-reviews, thematic issues based on mini-reviews and letters, commentaries, technical notes and drug clinical trial studies on major advances in all areas of drug metabolism and disposition.

In vitro systems including CYP-450; enzyme induction and inhibition; drug-drug interactions and enzyme kinetics; pharmacokinetics, toxicokinetics, species scaling and extrapolations; P-glycoprotein and transport carriers; target organ toxicity and interindividual variability; drug metabolism and disposition studies; extrahepatic metabolism; phase I and phase II metabolism; bioactivation; recent developments for the identification of drug metabolites, reactive intermediate and glutathione conjugates.

Drug Metabolism Letters

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Volume 14

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Number 3



SHORT COMMUNICATION

The Catalytic Activity of GSTM1 In vitro is Independent of MAPK8

, 14(3): 163 - 165

Shannon Robin, Khalil Ben Hassine, Simona Jurkovic Mlakar, Vid Mlakar, Marc Ansari* and Chakradhara Rao S. Uppugunduri*


DOI: 10.2174/1872312814666211122164456



Review Article

Physiological and Pathophysiological Role of Cysteine Metabolism in Human Metabolic Syndrome

, 14(3): 177 - 192

Arunachalam Muthuraman*, Muthusamy Ramesh*, Sohrab A. Shaikh, Subramanian Aswinprakash and Dhamodharan Jagadeesh


DOI: 10.2174/1872312814666211210111820


Research Article

Analysis between Linagliptin and Azithromycin: In vitro and In vivo Interaction Study

, 14(3): 193 - 205

Md. Didaruzzaman Sohel, Faisal Asif*, Tonmoy Kumar Mondal, Md. Helal Uddin Sumon and Md. Hassan Kawsar


DOI: 10.2174/1872312814666210910123056


Research Article




Corrigendum

Corrigendum: Inhibitory Effect of Codeine on Sucrase Activity

, 14(3): 232

Dariush Minai-Tehrani, Saeed Minoui, Marzie Sepehre, Zohre Sharif-Khodai and Tooka Aavani


DOI: 10.2174/187231281403211227125217



Articles Ahead of Print

There are currently no Articles Ahead of Print available for this journal.

Editor's Choice











Open Access Articles

Comparative <i>In vitro</i> Metabolism of Enflicoxib in Dogs, Rats, and Humans: Main Metabolites and Proposed Metabolic Pathways

, 2021; 14(3): 206 - 218

Josep Solà, Àngel Menargues, Josep Homedes*, Marta Salichs, Maria Teresa Serafini and Gregorio Encina




The Catalytic Activity of GSTM1 <i>In vitro</i> is Independent of MAPK8

, 2021; 14(3): 163 - 165

Shannon Robin, Khalil Ben Hassine, Simona Jurkovic Mlakar, Vid Mlakar, Marc Ansari* and Chakradhara Rao S. Uppugunduri*




Pharmacokinetics of Darolutamide, its Diastereomers and Active Metabolite in the Mouse: Response to Saini NK et al. (2020)

, 2021; 14(1): 9 - 16

Pirjo Nykänen, Timo Korjamo, Hille Gieschen, Christian Zurth and Mikko Koskinen*




Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture

, 2021; 14(1): 25 - 40

Shogo Ozawa*, Toshitaka Miura, Jun Terashima, Wataru Habano and Seiichi Ishida




The Metabolism of Methazolamide in Immortalized Human Keratinocytes, HaCaT Cells

, 2016; 10(4): 295 - 305

Tetsuo Sasabe*, Shinichiro Maeda, Kenichi Kishida, Mariko Yamano, Yoshihiro Miwa and Toshihiro Sugiyama




Efficiency in Drug Discovery: Liver S9 Fraction Assay As a Screen for Metabolic Stability

, 2016; 10(2): 83 - 90

Samantha J. Richardson, April Bai, Ashutosh A. Kulkarni and Mehran F. Moghaddam






Most Cited Articles

Research Article

Comparison of rat and human pulmonary metabolism using precision-cut lung slices (PCLS)

, 2019; 13(1): 53-63.

Yildiz Yilmaz*, Gareth Williams, Markus Walles, Nenad Manevski, Stephan Krähenbühl and Gian Camenisch


DOI: 10.2174/1872312812666181022114622


Research Article

Imatinib uptake into cells is not mediated by organic cation transporters OCT1, OCT2, or OCT3, but is influenced by extracellular pH

, 2019; 13(2): 102-110.

Jaurès B. Mettral, Nicolas Faller, Sandra Cruchon, Loïc Sottas, Thierry Buclin, Laurent Schild, Eva Choong, Aimable Nahimana and Laurent A. Decosterd*


DOI: 10.2174/1872312813666190207150207


Research Article

“Branched tail” oxyquinoline inhibitors of HIF prolyl hydroxylase: Early evaluation of toxicity and metabolism using liver-on-a-chip

, 2019; 13(1): 45-52.

Andrey A. Poloznikov*, Sergey V. Nikulin, Arpenik A. Zakhariants, Anna Y. Khristichenko, Dmitry M. Hushpulian, Ildar N. Gazizov, Vladimir I. Tishkov and Irina G. Gazaryan


DOI: 10.2174/1872312813666181129100950





Research Article

Transport of bupropion and its metabolites by the model CHO and HEK293 cell lines

, 2019; 13(1): 25-36.

Lyrialle W. Han, Chunying Gao, Yuchen Zhang, Joanne Wang and Qingcheng Mao*


DOI: 10.2174/1872312813666181129101507



Systematic Review Article

Major cyp450 polymorphism among saudi patients

, 2021; 14(1): 17-24.

Ahmad A. Almeman*


DOI: 10.2174/1872312814666200722122232




Research Article

An effective qwba/uhplc-ms/tissue punch approach: Solving a pharmacokinetic issue via quantitative met-id

, July 2021; 14(2): 152-162.

József Pánczél*, Manfred Schudok, Matthias Schiell, Jens Riedel and Vilmos Kertesz*


DOI: 10.2174/1872312814666210813114700


Letter Article

Pharmacokinetics of darolutamide, its diastereomers and active metabolite in the mouse: Response to saini nk et al. (2020)

, 2021; 14(1): 9-16.

Pirjo Nykänen, Timo Korjamo, Hille Gieschen, Christian Zurth and Mikko Koskinen*


DOI: 10.2174/1872312814666201112121129


Opinion Article

A short exploration of selected sensitive cyp3a4 substrates (Probe drug)

, 2021; 14(1): 2-4.

Sarvesh Sabarathinam and Thangavel M. Vijayakumar*


DOI: 10.2174/1872312814666200811110024


Research Article

Pharmacokinetics of darolutamide in mouse - assessment of the disposition of the diastereomers, key active metabolite and interconversion phenomenon: Implications to cancer patients

, 2021; 14(1): 54-65.

Neeraj K. Saini, Bhavesh B. Gabani, Umesh Todmal, Suresh P. Sulochana, Vinay Kiran, Mohd. Zainuddin, Narayanan Balaji, Sai B. Polina, Nuggehally R. Srinivas and Ramesh Mullangi*


DOI: 10.2174/1872312814666200521091236



Most Accessed Articles






Recent Progress in Prediction Systems for Drug-induced Liver Injury Using In vitro Cell Culture

, 2021; 14(1): 25-40.

Shogo Ozawa*, Toshitaka Miura, Jun Terashima, Wataru Habano and Seiichi Ishida


DOI: 10.2174/1872312814666201202112610


Pharmacokinetics of Darolutamide in Mouse - Assessment of the Disposition of the Diastereomers, Key Active Metabolite and Interconversion Phenomenon: Implications to Cancer Patients

, 2021; 14(1): 54-65.

Neeraj K. Saini, Bhavesh B. Gabani, Umesh Todmal, Suresh P. Sulochana, Vinay Kiran, Mohd. Zainuddin, Narayanan Balaji, Sai B. Polina, Nuggehally R. Srinivas and Ramesh Mullangi*


DOI: 10.2174/1872312814666200521091236





The Effect of Pomegranate Juice on the Expression of Some Murine UDP-Glucuronosyltransferases Genes

, 2021; 14(1): 89-93.

Yacoub M. Irshaid*, Ruba Alani, Razan Al-Rawashdeh, Tuqa Al-Ghazawi, Hiba Hijazi, Dana Amara, Amena Hammad, Zaineh M. Shahrure and Mohammad Al-Shhab


DOI: 10.2174/1872312814999201211203314


Hemodynamic Assessment and In vivo Catabolism of Adenosine 5’-triphosphate in Doxorubicin or Isoproterenol-induced Cardiovascular Toxicity

, 2021; 14(1): 80-88.

Pollen K. Yeung*, Sheyda Mohammadizadeh, Fatemeh Akhoundi, Kelsey Mann, Remigius U. Agu and Thomas Pulinilkunnil


DOI: 10.2174/1872312814666201022103802


Pharmacokinetics Parameters of Diagoxin among Saudi Patients in Qassim Region, Saudi Arabia

, 2021; 14(2): 137-140.

Abdulaziz S. Allihimy, Ahmad A. Almeman*, Nassar A. Alnassar and Jihad Almadhi


DOI: 10.2174/1872312814666210506121637





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