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Current Topics in Medicinal Chemistry

Volume 19, 32 Issues, 2019
ISSN: 1873-4294 (Online)
ISSN: 1568-0266 (Print)
This journal supports open access

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  • 20th of 61 in

    Chemistry, Medicinal

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Aims & Scope

Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.

Current Topics in Medicinal Chemistry

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Volume 19

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Number 18



Biography   Open Access



Editorial   Open Access



Review Article



Review Article

Recent Progress in the Development of HIV-1 Entry Inhibitors: From Small Molecules to Potent Anti-HIV Agents

, 19(18): 1599 - 1620

Khomson Suttisintong*, Narongpol Kaewchangwat, Eknarin Thanayupong, Chakkrapan Nerungsi, Onsiri Srikun and Pornpan Pungpo


DOI: 10.2174/1568026619666190712204050


Review Article   Open Access



Review Article



Articles Ahead of Print




Chemical Intuition in Drug Design and Discovery


Julia Galvez B. Pedreira, Lucas S. Franco and Eliezer J. Barreiro*


DOI: 10.2174/1568026619666190620144142
View Abstract View on PubMed




Antitumoral Potential of Lansbermin-I, a Novel Disintegrin from Porthidium lansbergii lansbergii Venom on Breast Cancer Cells


Leonel Montealegre-Sánchez*, Sarah N. C. Gimenes, Daiana S. Lopes, Samuel C. Teixeira, Luis Solano-Redondo, Veridiana de M. Rodrigues and Eliécer Jiménez-Charris*


DOI: 10.2174/1568026619666190806151401
View Abstract View on PubMed



Bothrops alternatus Snake Venom Induces Cytokine Expression and Oxidative Stress on Renal Function


Francisco Assis Nogueira Júnior, Antonio Rafael Coelho Jorge, Aline Diogo Marinho, João Alison de Moraes Silveira, Natacha Teresa Queiroz Alves, Pedro Henrique Sá Costa, Paula Letícia Braga e Silva, Adriano José Maia Chaves-Filho, Dânya Bandeira Lima, Tiago Lima Sampaio, Glayciane Bezerra de Morais, Janaina Serra Azul Monteiro Evangelista, Alice Maria Costa Martins, Rui Seabra Ferreira Jr., Danielle Silveira Macedo, Roberta Jeane Bezerra Jorge* and Helena Serra Azul Monteiro


DOI: 10.2174/1568026619666190809100319
View Abstract View on PubMed



Abstracts Ahead of Print





A Possible Modulation Mechanism of Intramolecular and Intermolecular Interactions for NCAM Polysialylation and Cell Migration


Bo Lu, Xue-Hui Liu, Si-Ming Lia, Zhi-Long Lu, Dong Chen, Frederic A. Troy II, Ri-Bo Huang and Guo-Ping Zhou*


DOI: 10.2174/1568026619666191018094805
View Abstract


Identifying cancer targets based on machine learning methods via Chou’s 5-steps rule and general pseudo components


Ruirui Liang, Jiayang Xie, Chi Zhang, Mengying Zhang, Hai Huang, Haizhong Huo, Xin Cao and Bing Niu*


DOI: 10.2174/1568026619666191016155543
View Abstract


The Present and Future of Novel Protein Degradation Technology


Liwen Xia, Wei Liu, Yinsen Song, Hailiang Zhu and Yongtao Duan*


DOI: 10.2174/1568026619666191011162955
View Abstract





Published Contents

Editor's Choice

Parallelization of Molecular Docking: A Review

, 2018; 18(12): 1015 - 1028

Dong Dong, Zhijian Xu, Wu Zhong and Shaoliang Peng*


DOI: 10.2174/1568026618666180821145215




A Review on Plant Antimicrobials of Past Decade

, 2018; 18(10): 812 - 833

Preet Amol Singh, Sapna D. Desai and Jasbir Singh*


DOI: 10.2174/1568026618666180516123229




Prediction and Targeting of Interaction Interfaces in G-protein Coupled Receptor Oligomers

, 2018; 18(8): 714 - 746

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610






Current Methods Applied to Biomaterials – Characterization Approaches, Safety Assessment and Biological International Standards

, 2018; 18(4): 256 - 274

Justine P.R. Oliveira*, H. Ivan Melendez-Ortiz, Emilio Bucio, Patricia Terra Alves, Mayara Ingrid Sousa Lima, Luiz Ricardo Goulart, Monica B. Mathor, Gustavo H.C. Varca and Ademar B. Lugao


DOI: 10.2174/1568026618666180410151518



Aurora Kinase Inhibitors in Head and Neck Cancer

, 2018; 18(3): 199 - 213

Guangying Qi, Jing Liu, Sisi Mi, Takaaki Tsunematsu, Shengjian Jin, Wenhua Shao, Tian Liu, Naozumi Ishimaru, Bo Tang* and Yasusei Kudo*


DOI: 10.2174/1568026618666180112163741



Open Access Articles

Discovery and Development of Anti-HIV Therapeutic Agents: Progress Towards Improved HIV Medication

, 2019; 19(18): 1621 - 1649

Kenji Maeda*, Debananda Das, Takuya Kobayakawa, Hirokazu Tamamura and Hiroaki Takeuchi*




Targeting the PAC1 Receptor for Neurological and Metabolic Disorders

, 2019; 19(16): 1399 - 1417

Chenyi Liao, Mathilde P. de Molliens, Severin T. Schneebeli, Matthias Brewer, Gaojie Song, David Chatenet, Karen M. Braas, Victor May* and Jianing Li*




Ensemble-Based Modeling of Chemical Compounds with Antimalarial Activity

, 2019; 19(11): 957 - 969

Ana Yisel Caballero-Alfonso, Maykel Cruz-Monteagudo, Eduardo Tejera, Emilio Benfenati, Fernanda Borges, M. Natália D.S. Cordeiro, Vinicio Armijos-Jaramillo and Yunierkis Perez-Castillo*






Treatment of Toxoplasmosis and Neosporosis in Farm Ruminants: State of Knowledge and Future Trends

, 2018; 18(15): 1304 - 1323

Roberto Sánchez-Sánchez, Patricia Vázquez, Ignacio Ferre and Luis Miguel Ortega-Mora*




Mechanical Properties of Composite Hydrogels for Tissue Engineering

, 2018; 18(14): 1214 - 1223

Ramon Rial, J.F. Armando Soltero, Pedro V. Verdes, Zhen Liu and Juan M. Ruso*





Analyzing of Molecular Networks for Human Diseases and Drug Discovery

, 2018; 18(12): 1007 - 1014

Tong Hao, Qian Wang, Lingxuan Zhao, Dan Wu, Edwin Wang* and Jinsheng Sun*




Toward Reproducible Results from Targeted Metabolomic Studies: Perspectives for Data Pre-processing and a Basis for Analytic Pipeline Development

, 2018; 18(11): 883 - 895

Thomas Gross, Mark Mapstone, Ricardo Miramontes, Robert Padilla, Amrita K. Cheema, Fabio Macciardi, Howard J. Federoff* and Massimo S. Fiandaca*





Ubiquitin Proteasome System as a Potential Drug Target for Malaria

, 2018; 18(5): 315 - 320

Pedro H. Scarpelli Pereira, Chiara Curra and Celia R.S. Garcia*




Metabolomics Applications in Precision Medicine: An Oncological Perspective

, 2017; 17(24): 2740 - 2751

Leonor Puchades-Carrasco and Antonio Pineda- Lucena*




InsP3 Signaling in Apicomplexan Parasites

, 2017; 17(19): 2158 - 2165

Celia R.S. Garcia*, Eduardo Alves, Pedro H. S. Pereira, Paula J. Bartlett, Andrew P. Thomas, Katsuhiko Mikoshiba, Helmut Plattner and L. David Sibley






Most Cited Articles

Review Article

Coumarin compounds in medicinal chemistry: Some important examples from the last years

, 2018; 18(2): 124-148.

Thiago Moreira Pereira, Daiana Portella Franco, Felipe Vitorio and Arthur Eugen Kummerle*


DOI: 10.2174/1568026618666180329115523


Review Article

Bis-coumarin derivatives and their biological activities

, 2018; 18(2): 101-113.

Qing-Cheng Ren, Chuan Gao , Zhi Xu , Lian-Shun Feng, Ming-liang Liu*, Xiang Wu* and Feng Zhao*


DOI: 10.2174/1568026618666180221114515


Review Article

Recent development of small molecule glutaminase inhibitors

, 2018; 18(6): 432-443.

Minsoo Song*, Soong-Hyun Kim, Chun Young Im and Hee-Jong Hwang


DOI: 10.2174/1568026618666180525100830



Review Article

Recent development of coumarin derivatives as potential antiplasmodial and antimalarial agents

, 2018; 18(2): 114-123.

Xin-Liang Hu, Chuan Gao, Zhi Xu, Ming-Liang Liu, Lian-Shun Feng and Guang-De Zhang*


DOI: 10.2174/1568026618666171215101158


Research Article

Structure-based virtual screening for the identification of high affinity compounds as potent VEGFR2 inhibitors for the treatment of renal cell carcinoma

, 2018; 18(25): 2174-2185.

Khushboo Sharma, Khushboo Patidar, Meer Asif Ali, Pravin Patil, Himshikha Goud, Tajamul Hussain, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026619666181130142237




Research Article

New benzothiazole-based thiazolidinones as potent antimicrobial agents. Design, synthesis and biological evaluation

, 2018; 18(1): 75-87.

Michelyne Haroun*, Christophe Tratrat, Katerina Kositzi, Evangelia Tsolaki, Anthi Petrou, Bandar Aldhubiab, Mahesh Attimarad, Sree Harsha, Athina Geronikaki*, Katharigatta N. Venugopala, Heba S. Elsewedy, Marina Sokovic, Jasna Glamoclija and Ana Ciric


DOI: 10.2174/1568026618666180206101814


Review Article

Applications of machine learning methods in drug toxicity prediction

, 2018; 18(12): 987-997.

Li Zhang, Hui Zhang, Haixin Ai, Huan Hu, Shimeng Li, Jian Zhao and Hongsheng Liu*


DOI: 10.2174/1568026618666180727152557


Review Article

Prediction and targeting of interaction interfaces in G-protein coupled receptor oligomers

, 2018; 18(8): 714-746.

Anke C. Schiedel, Meryem Kose, Carlos Barreto, Beatriz Bueschbell, Giulia Morra, Ozge Sensoy* and Irina S. Moreira*


DOI: 10.2174/1568026618666180604082610


Review Article

Learning from nature: Bioinspired strategies towards antimicrobial nanostructured systems

, 2018; 18(1): 22-41.

Giuseppe Vitiello, Brigida Silvestri and Giuseppina Luciani*


DOI: 10.2174/1568026618666180206101129


Review Article

Biological activities of artemisinin derivatives beyond malaria

, 2019; 19(3): 205-222.

Xiaoyan Liu, Jianguo Cao, Guozheng Huang*, Qingjie Zhao* and Jingshan Shen


DOI: 10.2174/1568026619666190122144217


Research Article

Structure-based virtual screening for the identification of high-affinity small molecule towards STAT3 for the clinical treatment of osteosarcoma

, 2018; 18(29): 2511-2526.

Ravina Khandelwal, Aashish Pratap Singh Chauhan, Swarnima Bilawat, Aishwarya Gandhe, Tajamul Hussain, Elizabeth Anne Hood, Anuraj Nayarisseri* and Sanjeev Kumar Singh*


DOI: 10.2174/1568026618666181115092001


Review Article

Tetramethoxyluteolin for the treatment of neurodegenerative diseases

, 2018; 18(21): 1872-1882.

Theoharis C. Theoharides* and Irene Tsilioni


DOI: 10.2174/1568026617666181119154247



Most Accessed Articles



3D-QSAR in Drug Design - A Review

, 2010; 10(1): 95-115.

Jitender Verma, Vijay M. Khedkar and Evans C. Coutinho


DOI: 10.2174/156802610790232260




An Overview on the Potential Antimycobacterial Agents Targeting Serine/Threonine Protein Kinases from Mycobacterium tuberculosis

, 2019; 19(9): 646-661.

Matteo Mori, José Camilla Sammartino, Luca Costantino, Arianna Gelain, Fiorella Meneghetti, Stefania Villa and Laurent Roberto Chiarelli*


DOI: 10.2174/1568026619666190227182701


How Cancer Cells Resist Chemotherapy: Design and Development of Drugs Targeting Protein-Protein Interactions

, 2019; 19(6): 394-412.

Vadim V. Tarasov, Vladimir N. Chubarev, Ghulam Md Ashraf, Samira A. Dostdar, Alexander V. Sokolov, Tatiana I. Melnikova, Susanna S. Sologova, Ekaterina M. Grigorevskich, Alfiya Makhmutovа, Alexander S. Kinzirsky, Sergey G. Klochkov and Gjumrakch Aliev*


DOI: 10.2174/1568026619666190305130141


In Vitro, In Silico and Ex Vivo Studies of Dihydroartemisinin Derivatives as Antitubercular Agents

, 2019; 19(8): 633-644.

Komal Kalani, Sarfaraz Alam, Vinita Chaturvedi, Shyam Singh, Feroz Khan and Santosh Kumar Srivastava*


DOI: 10.2174/1568026619666190305131425



Prediction of Drug-Drug Interactions Related to Inhibition or Induction of Drug-Metabolizing Enzymes

, 2019; 19(5): 319-336.

Alexander V. Dmitriev*, Alexey A. Lagunin, Dmitry А. Karasev, Anastasia V. Rudik, Pavel V. Pogodin, Dmitry A. Filimonov and Vladimir V. Poroikov


DOI: 10.2174/1568026619666190123160406




Editor-in-Chief

Allen B. Reitz
Fox Chase Chemical Diversity Center, Inc.
Doylestown, PA
USA

Biography View Full Editorial Board

Journal History

Current Topics in Medicinal Chemistry was introduced in 2001 with the assistance of Dr. Allen B. Reitz, who is the current Editor-in-Chief serving since 2001.
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Scopus CiteScore Metrics: 1.94


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