Bentham Science Logo

Current Drug Metabolism

Volume 20, 14 Issues, 2019
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Ranking and Category

  • 200th of 298 in

    Biochemistry & Molecular Biology

  • 158th of 267 in

    Pharmacology & Pharmacy

Order Your Article Before Print

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism

,

Volume 20

-

Number 9



Biography   Open Access



Perspective   Open Access



Review Article



Review Article



Review Article



Research Article



Research Article



Research Article



Articles Ahead of Print



Possible Pathways of Hepatotoxicity Caused by Chemical Agents


Roohi Mohi-ud-din*, Reyaz Hassan Mir*, Gifty Sawhney, Mohd Akbar Dar, Mubashir Hussain Masoodi and Zulfiqar Ali Bhat


DOI: 10.2174/1389200220666191105121653
View Abstract View on PubMed


Evaluation of Pharmacokinetic Interaction of Cilostazol with Metoclopramide After Oral Administration in Human


Iram Kaukab, Syed Nisar Hussain Shah, Zelal Kharaba, Ghulam Murtaza*, Abubaker Ali Saad and Shakeel Ahmad


DOI: 10.2174/1389200220666191105115805
View Abstract View on PubMed



Higher Atazanavir Plasma Exposure in Rats is Associated with Gut Microbiota Changes Induced by Cotrimoxazole


Miantezila Basilua Joe*, Sawoo Olivier, Mangin Irène, Dossou-Yovo Flore, Boussard Aline, Chevillard Lucie, Tona Lutete Gaston, Eto Bruno, Peytavin Gilles and Pochart Philippe


DOI: 10.2174/1389200220666191023105609
View Abstract


Expression Level of MiRNA-126 In Serum Exosomes of Allergic Asthma Patients and Lung Tissues of Asthmatic Mice


Mei-Zhen Zhao*, Yu-Pei Li*, Xiao-Rui Geng, Miao Zhao, Shi-Bo Ma, Yu-Huang Yang, Zu-Hui Deng, Li-Mei Luo and Xin-Quan Pan


DOI: 10.2174/1389200220666191011114452
View Abstract


TPMT Genotype and Adverse Effects of Azathioprine Among Jordanian Group


Mohammed M. Mhanna, Munir Gharaibeh, Mohammad Rashid, Ahmad Sharab, Mohammad Shehab and Malek Zihlif


DOI: 10.2174/1389200220666191021100953
View Abstract View on PubMed




Abstracts Ahead of Print



A Retrospective Look at Anti-EGFR Agents in Pancreatic Cancer Therapy


Henu Kumar Verma, Praveen Kumar Kampalli, Saikrishna Lakkakula, Gayathri Chalikonda, Bhaskar V.K.S. Lakkakula* and Smaranika Pattnaik


DOI: 10.2174/1389200220666191122104955
View Abstract


Novel Phytochemical Constituents and Anticancer Activities of the genus, Typhonium


Shaik Ibrahim Khalivulla, Arifullah Mohammed*, Kuttulebbai Nainamohamed Ainamohamed Salam Sirajudeen, Mannur Ismail Shaik, Weibing Ye and Mallikarjuna Korivi*


DOI: 10.2174/1389200220666191118102616
View Abstract



Published Contents

Editor's Choice


Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*


DOI: 10.2174/1389200220666190701094756



Interethnic Variations of UGT1A1 and UGT1A7 Polymorphisms in the Jordanian Population

, 2019; 20(5): 399 - 410

Sara Abudahab*, Nancy Hakooz, Yazun Jarrar, Mohammad Al Shahhab, Ahmad Saleh, Malek Zihlif and Rana Dajani


DOI: 10.2174/1389200220666190528085151



Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*


DOI: 10.2174/1389200220666190111114146







Sodium Oxybate Therapy for Alcohol Withdrawal Syndrome and Keeping of Alcohol Abstinence

, 2018; 19(13): 1056 - 1064

Carmen Mannucci, Simona Pichini, Elvira Ventura Spagnolo, Fabrizio Calapai, Sebastiano Gangemi, Michele Navarra and Gioacchino Calapai*


DOI: 10.2174/1389200219666171207122227




Open Access Articles

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*




Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*




Decreased Disposition of Anticancer Drugs Predominantly Eliminated via the Liver in Patients with Renal Failure

, 2019; 20(5): 361 - 376

Ken-ichi Fujita *, Natsumi Matsumoto, Hiroo Ishida, Yutaro Kubota, Shinichi Iwai, Motoko Shibanuma and Yukio Kato




Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*






Survey of Drug Oxidation Activities in Hepatic and Intestinal Microsomes of Individual Common Marmosets, a New Nonhuman Primate Animal Model

, 2019; 20(2): 103 - 113

Shotaro Uehara, Toru Oshio, Kazuyuki Nakanishi, Etsuko Tomioka, Miyu Suzuki, Takashi Inoue, Yasuhiro Uno, Erika Sasaki and Hiroshi Yamazaki*





Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*




Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*






Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota




Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti




Preclinical Pharmacokinetics, Pharmacodynamics and Safety of Sucroferric Oxyhydroxide

, 2014; 15(10): 953 - 965

Mario Cozzolino, Felix Funk, Viatcheslav Rakov, Olivier Phan and Isaac Teitelbaum





Most Cited Articles

Review Article

Medicinal and therapeutic potential of herbs and plant metabolites/extracts countering viral pathogens-current knowledge and future prospects

, 2018; 19(3): 236-263.

Kuldeep Dhama*, Kumaragurubaran Karthik, Rekha Khandia, Ashok Munjal, Ruchi Tiwari, Rajneesh Rana, Sandip Kumar Khurana, Sana Ullah, Rifat Ullah Khan, Mahmoud Alagawany, Mayada Ragab Farag, Maryam Dadar and Sunil Kumar Joshi


DOI: 10.2174/1389200219666180129145252


Review Article

Long circulating polymeric nanoparticles for gene/drug delivery

, 2018; 19(9): 723-738.

Jiaming Hu, Yan Sheng*, Junfeng Shi, Bohao Yu, Zhiqiang Yu and Guochao Liao*


DOI: 10.2174/1389200219666171207120643


Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*


DOI: 10.2174/1389200219666180820112457


Review Article

Herbal immunomodulators - A remedial panacea for designing and developing effective drugs and medicines: Current scenario and future prospects

, 2018; 19(3): 264-301.

Ruchi Tiwari*, Shyma K. Latheef, Ishtiaq Ahmed, Hafiz M.N. Iqbal, Mohammed Hussen Bule, Kuldeep Dhama, Hari Abdul Samad, Kumaragurubaran Karthik, Mahmoud Alagawany, Mohamed Ezzat Abd El-Hack, Mohd. Iqbal Yatoo and Mayada Ragab Farag


DOI: 10.2174/1389200219666180129125436


Review Article

Role of mitochondrial mechanism in chemotherapy-induced peripheral neuropathy

, 1 January 2018; 19(1): 47-54.

Mohammad Waseem, Pooja Kaushik, Heena Tabassum* and Suhel Parvez


DOI: 10.2174/1389200219666171207121313




Review Article

An insight into the therapeutic potential of major coffee components

, 2018; 19(6): 544-556.

Muhammad Torequl Islam*, Shams Tabrez*, Nasimudeen R. Jabir, Murtaza Ali, Mohammad Amjad Kamal, Lidiane da Silva Araujo, Jose Victor De Oliveira Santos, Ana Maria Oliveira Ferreira Da Mata, Rai Pablo Sousa De Aguiar and Ana Amelia de Carvalho Melo Cavalcante


DOI: 10.2174/1389200219666180302154551


Review Article

Adverse events of proton pump inhibitors: Potential mechanisms

, 2018; 19(2): 142-154.

Andrea Corsonello*, Fabrizia Lattanzio, Silvia Bustacchini, Sabrina Garasto, Annalisa Cozza, Roberto Schepisi, Federica Lenci, Filippo Luciani, Marcello Giuseppe Maggio, Andrea Ticinesi, Valeria Butto, Sara Tagliaferri and Francesco Corica


DOI: 10.2174/1389200219666171207125351


General Review Article

Anti-cancer effects of metformin: Recent evidences for its role in prevention and treatment of cancer

, 2018; 19(9): 793-797.

Masoumeh Kheirandish, Hamidreza Mahboobi*, Maryam Yazdanparast, Warda Kamal and Mohammad Amjad Kamal


DOI: 10.2174/1389200219666180416161846


General Review Article

Essential oils: Extraction techniques, pharmaceutical and therapeutic potential - A review

, 2018; 19(13): 1100-1110.

Zarith Asyikin Abdul Aziz, Akil Ahmad, Siti Hamidah Mohd Setapar*, Alptug Karakucuk, Muhammad Mohsin Azim, David Lokhat, Mohd. Rafatullah, Magdah Ganash, Mohammad A. Kamal and Ghulam Md Ashraf*


DOI: 10.2174/1389200219666180723144850



Review Article

Replacing GHB with GBL in recreational settings: A new trend in chemsex

, 2018; 19(13): 1080-1085.

Francesco Paolo Busardò*, Massimo Gottardi, Anastasio Tini, Adele Minutillo, Ascanio Sirignano, Enrico Marinelli and Simona Zaami


DOI: 10.2174/1389200219666180925090834


Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin


DOI: 10.2174/1389200219666181031105916


Review Article

Plant-derived polyphenols in human health: Biological activity, metabolites and putative molecular targets

, 2018; 19(4): 351-369.

Marilo Olivares-Vicente, Enrique Barrajon-Catalan*, Maria Herranz-Lopez, Antonio Segura-Carretero, Jorge Joven, Jose Antonio Encinar and Vicente Micol


DOI: 10.2174/1389200219666180220095236



Most Accessed Articles


Cannabinoids and Cytochrome P450 Interactions

, 2016; 17(3): 206-226.

Ondřej Zendulka, Gabriela Dovrtělová, Kristýna Nosková, Miroslav Turjap, Alexandra Šulcová, Lumír Hanuš and Jan Juřica


DOI: 10.2174/1389200217666151210142051



Metabolism of the Dual Orexin Receptor Antagonist ACT-541468, Based on Microtracer/ Accelerator Mass Spectrometry

, 2019; 20(4): 254-265.

Clemens Muehlan*, Hartmut Fischer, Dieter Zimmer, Hamed Aissaoui, Julien Grimont, Christoph Boss, Marie Croft, Joop van Gerven, Stephan Krähenbühl and Jasper Dingemanse


DOI: 10.2174/1389200220666190206141814


Association of Genetic Variants in CYP3A4, CYP3A5, CYP2C8, and CYP2C19 with Tacrolimus Pharmacokinetics in Renal Transplant Recipients

, 2019; 20(7): 609-618.

Zijie Wang, Ming Zheng, Haiwei Yang, Zhijian Han, Jun Tao, Hao Chen, Li Sun, Miao Guo, Libin Wang, Ruoyun Tan, Ji-Fu Wei* and Min Gu*


DOI: 10.2174/1389200220666190627101927






Nanomedicine: Bioavailability, Biotransformation and Biokinetics

, 2019; 20(7): 542-555.

Selvan Ravindran*, Amlesh J. Tambe, Jitendra K. Suthar, Digamber S. Chahar, Joyleen M. Fernandes and Vedika Desai


DOI: 10.2174/1389200220666190614150708




Editor-in-Chief

Michael Sinz
Bristol Myers Squibb
Princeton, NJ
USA

Biography View Full Editorial Board

Journal History

Current Drug Metabolism was launched in 2000. Dr. Michael Sinz serves as the Editor-in-Chief of the journal.
Track Your Manuscript:


Scopus CiteScore Metrics: 2.22

Related Journals

Related eBooks

eBooks Catalog