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Current Drug Metabolism

Volume 23, 14 Issues, 2022
ISSN: 1875-5453 (Online)
ISSN: 1389-2002 (Print)
This journal supports open access

Aims & Scope

Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism, pharmacokinetics, and drug disposition. The journal serves as an international forum for the publication of full-length/mini review, research articles and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical scientists who wish to be kept informed and up-to-date with the most important developments. The journal covers the following general topic areas: pharmaceutics, pharmacokinetics, toxicology, and most importantly drug metabolism.

More specifically, in vitro and in vivo drug metabolism of phase I and phase II enzymes or metabolic pathways; drug-drug interactions and enzyme kinetics; pharmacokinetics, pharmacokinetic-pharmacodynamic modeling, and toxicokinetics; interspecies differences in metabolism or pharmacokinetics, species scaling and extrapolations; drug transporters; target organ toxicity and interindividual variability in drug exposure-response; extrahepatic metabolism; bioactivation, reactive metabolites, and developments for the identification of drug metabolites. Preclinical and clinical reviews describing the drug metabolism and pharmacokinetics of marketed drugs or drug classes.

Current Drug Metabolism


Volume 22


Number 14

Research Article

Research Article

Identification and Quantification of MIDD0301 Metabolites

, 22(14): 1114 - 1123

M.S. Rashid Roni, Nicolas M. Zahn, Brandon N. Mikulsky, Daniel A. Webb, Md Yeunus Mian, Daniel E. Knutson, Margaret L. Guthrie, James M. Cook, Douglas C. Stafford and Leggy A. Arnold*

DOI: 10.2174/1389200222666211202093841

Research Article

Higher Teicoplanin Blood Level Needed in Elderly Critically Ill Patients

, 22(14): 1124 - 1131

Ling Wang, Mingguang Chen, Hong Ye, Xiaolan Lin, Yixuan Li, Junshan Ruan*, Fenghui Lin* and Yuxing Lin

DOI: 10.2174/1389200222666211122124420

Research Article

Clinical Trial

A Randomized Trial of Short-term Treatment with Folic Acid to Reduce the Oxidative Stress of Patients with Chronic Kidney Disease

, 22(14): 1139 - 1150

Andressa Keiko Matsumoto*, Ana Paula Michelin, Laura de Oliveira Semeão, Walter Sepúlveda-Loyola, João Victor de Lima Pedrão, Guilherme Martins Porto, Beatriz Suellen Arceni, Estefânia Gastaldello Moreira, Vinicius Daher Alvares Delfino and Décio Sabbatini Barbosa

DOI: 10.2174/1389200222666211210153145

Current Drug Metabolism, Volume 23 (2022) - Number 1

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

miRNAs in SARS-CoV-2 Infection: An Update

Asim Azhar*, Wajihul Hasan Khan, Khaled Al-hosaini and Mohammad Amjad Kamal

DOI: 10.2174/1389200223666220321102824
View Abstract View on PubMed

Therapeutic Approaches to Amyotrophic Lateral Sclerosis from the Lab to the Clinic

Vivek Chavda*, Chirag Patel, Dharti Modh, Yavuz Nuri Ertas, Shreya S. Sonak, Nafisa K. Munshi, Krishna Anand*, Arun Soni and Sonal Pandey

DOI: 10.2174/1389200223666220310113110
View Abstract View on PubMed

Simultaneous Method Development and Validation of Anastrozole Along with Piperine: Degradation Studies and Degradants Characterization Using LC-QTOF-ESI-MS Along with In-silico ADMET Predictions

K. Jony Susanna, Rahul Gajbhiye, Bhaskar Sarmah, Sachin Dattram Pawar, Pakhuri Mehta, Upadhyayula Suryanarayana Murty, V. Ravichandiran, Amit Alexander and Pramod Kumar*

DOI: 10.2174/1389200223666220215152606
View Abstract View on PubMed

Orchestration of Obesolytic Activity of Microbiome: Metabiotics at Centre Stage

Bhupinder Kapoor, Apoorva Singh, Monica Gulati*, Sachin Kumar Singh, Pooja Rani, Qushmua Alzahrani, Kamal Dua, Harish Dureja and Leander Corrie

DOI: 10.2174/1389200223666220211095024
View Abstract View on PubMed

Inhibition of Cytochrome P450 Enzyme and Drug-Drug Interaction Potential of Acid Reducing Agents Used in Management of CDK Inhibitors for Breast Cancer Chemotherapy

Prajakta Harish Patil, Puralae Channabasavaiah Jagadish*, Fajeelath Fatima, Sumit Birangal, Gurupur Gautham Shenoy, Mahadev Rao, Junaid Farooqui, Himanshu Rastogi, Tarun Sharma and Jakir Pinjari

DOI: 10.2174/1389200223666220218090948
View Abstract View on PubMed

Abstracts Ahead of Print

Impact of POR*28 Variant on Tacrolimus Pharmacokinetics in Kidney Transplant Patients with Different CYP3A5 Genotypes

Janaina B. F. Everton, Fernando J. B. Patrício, Manuel S. Faria, Teresa C. A. Ferreira, Natalino Salgado Filho, Gyl E. B. Silva, Elen A. Romão and Marcelo Magalhães*

DOI: 10.2174/1389200223666220516094226
View Abstract

Recent Advances in Nanotechnology-Based Targeted Therapeutics for Breast Cancer Management

Abdulsalam Alhalmi, Sarwar Beg, Waleed H. Almalki, Saad Alghamdi and Kanchan Kohli*

DOI: 10.2174/1389200223666220514151110
View Abstract

Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s

Vijay Nirusimhan, Daniel Andrew Gideon*, Abhinav Parashar, Sangavi Jeyachandran, Jeyakanthan Jeyaraman, Gowthamkumar Subbaraj and Langeswaran Kulanthaivel*

DOI: 10.2174/1389200223666220511162234
View Abstract

Interactions between meropenem and renal drug transporters

Jing Dong, Yanhui Liu, Longxuan Li*, Yunhe Ding, Jun Qian and Zheng Jiao*

DOI: 10.2174/1389200223666220428081109
View Abstract

Elevated Urinary Tissue Inhibitor Of Metalloproteinase-2 And Insulin-Like Growth Factor Binding Protein-7 Predict Drug-Induced Acute Kidney Injury

K Akalya, Tanusya Murali Murali, Anantharaman Vathsala, Boon-Wee Teo, Sanmay Low, Dharmini Dharmasegaran, Liang-Piu Koh, Glenn Kunnath Bonney, Wei-Zhen Hong, Yi Da and Horng-Ruey Chua*

DOI: 10.2174/1389200223666220425111931
View Abstract

Receptor-Mediated Targeting in Breast Cancer through Solid Lipid Nanoparticles and Its Mechanism

Zoya Malik, Rabea Parveen, Sageer Abass, Mohammad Irfan, Syed Akhtar Husain* and Sayeed Ahmad*

DOI: 10.2174/1389200223666220416213639
View Abstract

Published Contents

Editor's Choice

Metabolite Identification in the Preclinical and Clinical Phase of Drug Development

, 2021; 22(11): 838 - 857

Yali Wu, Lulu Pan, Zhendong Chen, Yuandong Zheng, Xingxing Diao* and Dafang Zhong*

DOI: 10.2174/1389200222666211006104502

In vitro Measurement and In vivo Prediction of Time-Dependent Inhibitory Effects of Three Tyrosine Kinase Inhibitors on CYP3A Activity

, 2021; 22(10): 802 - 810

Liyan Wang, Tingting Zhao, Yunxiang Wang, Banglian Hu, Jianfei Tao, Jinshan Ke, Tingfei Wei, Guangbo Ge, Qiang Meng, Changyuan Wang, Qi Liu, Huijun Sun, Jingjing Wu* and Yanwei Chen*

DOI: 10.2174/1389200222666210902130319

An Overview of Dietary Supplements on Obesity and Type 2 Diabetes: Efficacy and Mechanisms

, 2021; 22(6): 415 - 440

Xiaohong Liu, Xin Zeng, Wen Liu, Yanrong Lu, Jingqiu Cheng and Younan Chen*

DOI: 10.2174/1389200222666210406110450

Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198 - 207

Adiba Sultana, Rajeev K. Singla, Xuefei He, Yan Sun, Md. Shahin Alam and Bairong Shen*

DOI: 10.2174/1389200221999201116143701

Open Access Articles

Glutamine Antagonist GA-607 Causes a Dramatic Accumulation of FGAR which can be used to Monitor Target Engagement

, 2021; 22(9): 735 - 745

Jesse Alt , Sadakatali S. Gori, Kathryn M. Lemberg, Arindom Pal , Vijayabhaskar Veeravalli, Ying Wu, Joanna M.H. Aguilar , Ranjeet P. Dash, Lukáš Tenora , Pavel Majer, Qi Sun, Barbara S. Slusher* and Rana Rais*

Dysregulation of lncRNA and circRNA Expression in Mouse Testes after Exposure to Triptolide

, 2019; 20(8): 665 - 673

Suping Xiong, Yanting Li, Yang Xiang, Na Peng, Chunmiao Shen, Yanqiu Cai, Dandan Song, Peng Zhang, Xiaolong Wang, Xuihui Zeng and Xiaoning Zhang*

Influence of the OATP Polymorphism on the Population Pharmacokinetics of Methotrexate in Chinese Patients

, 2019; 20(7): 592 - 600

Zhiqi Wang, Nan Zhang, Chaoyang Chen, Shuqing Chen, Junyu Xu, Ying Zhou, Xia Zhao* and Yimin Cui*

Effects of CYP2C8 and SLCO1B1 Genetic Polymorphisms on Repaglinide Pharmacokinetics: A Systematic Review and Meta-Analysis

, 2019; 20(4): 266 - 274

Shuang Zhou, Qian Xiang, Guangyan Mu, Lingyue Ma, Shuqing Chen, Qiufen Xie, Zhuo Zhang and Yimin Cui*

Thiazide Therapy in Chronic Kidney Disease: Renal and Extra Renal Targets

, 2018; 19(12): 1012 - 1020

Negiin Pourafshar*, Saeed Alshahrani, Ashkan Karimi and Manoocher Soleimani*

Models of Drug Induced Liver Injury (DILI) – Current Issues and Future Perspectives

, 2018; 19(10): 830 - 838

Lucija Kuna, Ivana Bozic, Tomislav Kizivat, Kristina Bojanic, Margareta Mrso, Edgar Kralj, Robert Smolic, George Y. Wu and Martina Smolic*

Digestive Enzyme Supplementation in Gastrointestinal Diseases

, 2016; 17(2): 187 - 193

Gianluca Ianiro, Silvia Pecere, Valentina Giorgio, Antonio Gasbarrini and Giovanni Cammarota

Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines

, 2015; 16(6): 412 - 426

Derek W. Edwardson, Rashmi Narendrula, Simon Chewchuk, Kyle Mispel-Beyer, Jonathan P.J. Mapletoft and Amadeo M. Parissenti

Most Cited Articles

Review Article

Survey of machine learning techniques in drug discovery

, 2019; 20(3): 185-193.

Natalie Stephenson, Emily Shane, Jessica Chase, Jason Rowland, David Ries, Nicola Justice, Jie Zhang, Leong Chan and Renzhi Cao*

DOI: 10.2174/1389200219666180820112457

Review Article

Recent advances in machine learning methods for predicting heat shock proteins

, 2019; 20(3): 224-228.

Wei Chen*, Pengmian Feng, Tao Liu and Dianchuan Jin

DOI: 10.2174/1389200219666181031105916

Review Article

Cancer nanotechnology: A new revolution for cancer diagnosis and therapy

, 2019; 20(6): 416-429.

Vivek K Chaturvedi, Anshuman Singh, Vinay K. Singh and Mohan P. Singh*

DOI: 10.2174/1389200219666180918111528

Review Article

Magnetic nanoparticles: Current trends and future aspects in diagnostics and nanomedicine

, 2019; 20(6): 457-472.

Naga Veera Srikanth Vallabani, Sanjay Singh* and Ajay Singh Karakoti*

DOI: 10.2174/1389200220666181122124458

Review Article

Herb-drug interactions and hepatotoxicity

, 2019; 20(4): 275-282.

Mohammad K. Parvez* and Vikas Rishi

DOI: 10.2174/1389200220666190325141422

Review Article

Recent advances in the machine learning-based drug-target interaction prediction

, 2019; 20(3): 194-202.

Wen Zhang*, Weiran Lin, Ding Zhang, Siman Wang, Jingwen Shi and Yanqing Niu

DOI: 10.2174/1389200219666180821094047

Review Article

Survey of machine learning techniques for prediction of the isoform specificity of cytochrome P450 substrates

, 2019; 20(3): 229-235.

Yi Xiong, Yanhua Qiao, Daisuke Kihara, Hui-Yuan Zhang, Xiaolei Zhu* and Dong-Qing Wei*

DOI: 10.2174/1389200219666181019094526

General Review Article

Advanced glycation end products (AGEs), glutathione and breast cancer: Factors, mechanism and therapeutic interventions

, 2019; 20(1): 65-71.

Anil K. Sharma, Var R. Sharma, Girish K. Gupta, Ghulam Md. Ashraf and Mohammad A. Kamal*

DOI: 10.2174/1389200219666180912104342

Most Accessed Articles

Modulation of Drug Resistance by Limonene: Inhibition of Efflux Pumps in Staphylococcus aureus Strains RN-4220 and IS-58

, 2021; 22(2): 110-113.

de Araujo, Ana C. J.; Freitas, Priscilla R.; dos Santos Barbosa, Cristina R.; Muniz, Debora F.; Ribeiro-Filho, Jaime; Tintino, Saulo R.; Junior, Jose P. S.; Filho, Jose M. B.; de Sousa, Gabriela R.; Coutinho, Henrique D. M.

DOI: 10.2174/1389200221999210104204718

Modulation of the Drug Resistance by Platonia insignis Mart. Extract, Ethyl Acetate Fraction and Morelloflavone/Volkensiflavone (Biflavonoids) in Staphylococcus aureus Strains Overexpressing Efflux Pump Genes

, 2021; 22(2): 114-122.

Silva, Andressa K. F. E.; dos Reis, Antonielly C.; Pinheiro, Emanuelly E. A.; de Sousa, Jonas N.; de Alcantara Oliveira, Felipe A.; Moura, Arkellau K. S.; Neto, Jose de Souza L.; Cito, Antonia M. das Gracas L.; Siqueira-Junior, Jose P.; Kaatz, Glenn W.; Barreto, Humberto M.

DOI: 10.2174/1389200221666200523155617

Metabolism and Mechanism of Human Cytochrome P450 Enzyme 1A2

, 2021; 22(1): 40-49.

Guo, Jingchao; Zhu, Xiaohui; Badawy, Sara; Ihsan, Awais; Liu, Zhenli; Xie, Changqing; Wang, Xu

DOI: 10.2174/1389200221999210101233135

Topical Capsaicin for the Treatment of Neuropathic Pain

, 2021; 22(3): 198-207.

Sultana, Adiba; Singla, Rajeev K.; He, Xuefei; Sun, Yan; Alam, Md Shahin; Shen, Bairong

DOI: 10.2174/1389200221999201116143701

A Novel Nanoformulation of Ellagic Acid is Promising in Restoring Oxidative Homeostasis in Rat Brains with Alzheimer's Disease

, 2021; 22(4): 299-307.

Harakeh, Steve; Qari, Mohamad H.; Ramadan, Wafaa S.; Al Jaouni, Soad K.; Almuhayawi, Mohammed S.; Al Amri, Turki; Ashraf, Ghulam Md; Bharali, Dhruba J.; Mousa, Shaker A.

DOI: 10.2174/1389200221666201216170851

Effectiveness and Tolerability of Very-low Volume Preparation for Colonoscopy: A Narrative Review

, 2021; 22(2): 85-88.

Sinagra, Emanuele; Sferrazza, Sandro; Vitello, Alessandro; Morreale, Gaetano; Rossi, Francesca; Conoscenti, Giuseppe; Pallio, Socrate; Raimondo, Dario; Maida, Marcello

DOI: 10.2174/1389200221999201208212007

The Emerging Roles of Extracellular Vesicles in Ovarian Cancer

, 2021; 22(2): 139-149.

Wang, Yin-Xue; Wang, Yi-Xiang; Li, Yi-Ke; Tu, Shi-Yan; Wang, Yi-Qing

DOI: 10.2174/1389200221666201110155721

Advances in Understanding the Metabolites and Metabolomics of Polygonum multiflorum Thunb: A Mini-review

, 2021; 22(3): 165-172.

Yang, Jian-Bo; Gao, Hui-Yu; Song, Yun-Fei; Liu, Yue; Wang, Qi; Wang, Ying; Ma, Shuang-Cheng; Cheng, Xian-Long; Wei, Feng

DOI: 10.2174/1389200221666201201091345


Ming Hu
College of Pharmacy
University of Houston
Houston, TX
(United States)
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Journal History

Current Drug Metabolism was launched in 2000. Dr. Ming Hu serves as the Editor-in-Chief of the journal.



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