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Current Drug Targets

Volume 23, 17 Issues, 2022
ISSN: 1873-5592 (Online)
ISSN: 1389-4501 (Print)
This journal supports open access

Aims & Scope

Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.

Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication full-length/mini review articles and drug clinical trial studies.

As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.

Current Drug Targets


Volume 23


Number 9

Review Article

Bugs as Drugs: Understanding the Linkage between Gut Microbiota and Cancer Treatment

, 23(9): 869 - 888

Dhwani Rana, Sagar Salave, Akhil Perla, Akanksha Nadkarni, Shital Kolhe, Anil B. Jindal, Amit Mandoli, Pradeep Dwivedi* and Derajram Benival*

DOI: 10.2174/1389450123666220309101345

Current Drug Targets, Volume 23 (2022) - Number 11

This issue is in progress but contains articles that are final and fully citable.

Current Drug Targets, Volume 23 (2022) - Number 10

This issue is in progress but contains articles that are final and fully citable.

Articles Ahead of Print

Bacterial Metalo-Aminopeptidases as Targets in Human Infectious Diseases

Jorge González-Bacerio*, Ana C. Varela, Mirtha Elisa Aguado, Maikel Izquierdo, Yanira Méndez, Maday Alonso del Rivero and Daniel G. Rivera

DOI: 10.2174/1389450123666220316085859
View Abstract View on PubMed

Vascular Endothelial Dysfunction in Ischemic Reperfusion Injury Needs Constant Updating

Ricardo Oliveira dos Santos Soares, Agnes Afrodite Sumarelli Albuquerque and Paulo Roberto Barbosa Evora*

DOI: 10.2174/1389450123666220519170221
View on PubMed

Current Research Trends in Cytokine Storm: A Scientometric Study

Kun-Tang Wang, Dong Xu, Yi-Lun Wang, Xin-Ran Dong, Jie Tang, Yue Wang, Tao Qiao, Han Zhang, Qiang-Song Wang* and Yuan-Lu Cui*

DOI: 10.2174/1389450123666220414135249
View Abstract View on PubMed

Hybrid-Compounds Against Trypanosomiases

Jessica Alves Nunes and Edeildo Ferreira da Silva-Júnior*

DOI: 10.2174/1389450123666220509202352
View Abstract View on PubMed

Abstracts Ahead of Print

Therapeutic approaches for combating Aspergillus associated infection

Aruna Punia, Pooja Choudhary, Namita Sharma, Sweety Dahiya, Prity Gulia and Anil K. Chhillar*

DOI: 10.2174/1389450123666220623164548
View Abstract

Prospection of microfluidics for local drug delivery

N. Raghavendra Naveen*, D. Girirajasekhar, Prakash S. Goudanavar, Gunturu Lakshmi Narasimha and C. Bharat Kumar

DOI: 10.2174/1389450123666220404154710
View Abstract

Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy

Sheetu, Tapan Behl, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Saurabh Bhatia, Ahmed Al-Harassi, Simona Bungau and Ebrahim Mostafavi*

DOI: 10.2174/1389450123666220301110140
View Abstract

Published Contents

Editor's Choice

Small-molecule Antiviral Agents in Ongoing Clinical Trials for COVID-19

, 2021; 22(17): 1986 - 2005

Çağla Begüm Apaydın, Gözde Çınar and Gökçe Cihan-Üstündağ*

DOI: 10.2174/1389450122666210215112150

GSK-3 Inhibitors: A New Class of Drugs for Alzheimer’s Disease Treatment

, 2021; 22(15): 1725 - 1737

Dilipkumar Pal, Souvik Mukherjee, In-Ho Song and Satish B. Nimse*

DOI: 10.2174/1389450122666210114095307

Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

, 2021; 22(14): 1596 - 1617

Cristina Daneri-Becerra, Sol M. Ciucci, Gisela Mazaira and Mario D. Galigniana*

DOI: 10.2174/1389450121999201230204320

New Framework for the Discovery of PRC2 Inhibitors: Epigenetic Drugs

, 2021; 22(11): 1198 - 1206

Danishuddin, Naidu Subbarao*, Mohd Khan, Sultan Alouffi and Shahper Khan*

DOI: 10.2174/1389450122666210215111744

The Emergence of Immune-checkpoint Inhibitors in Colorectal Cancer Therapy

, 2021; 22(9): 1021 - 1033

Michele Ghidini*, Nicola Fusco, Massimiliano Salati, Shelize Khakoo, Gianluca Tomasello, Fausto Petrelli, Dario Trapani and Angelica Petrillo

DOI: 10.2174/1389450122666210204204415

Open Access Articles

Characteristic of Cyclodextrins: Their Role and Use in the Pharmaceutical Technology

, 2020; 21(14): 1495 - 1510

Malwina Lachowicz*, Andrzej Stańczak and Michał Kołodziejczyk

Opportunities of Bacterial Cellulose to Treat Epithelial Tissues

, 2019; 20(8): 808 - 822

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch

Blood Eosinophils as Biomarkers to Drive Treatment Choices in Asthma and COPD

, 2018; 19(16): 1882 - 1896

Konstantinos Kostikas, Caterina Brindicci and Francesco Patalano*

Current Status and Perspectives on Pharmacologic Therapy for Abdominal Aortic Aneurysm

, 2018; 19(11): 1265 - 1275

Koichi Yoshimura*, Noriyasu Morikage, Shizuka Nishino-Fujimoto, Akira Furutani, Bungo Shirasawa and Kimikazu Hamano

TXNIP in Metabolic Regulation: Physiological Role and Therapeutic Outlook

, 2017; 18(9): 1095 - 1103

Naif Mohammad Alhawiti, Saeed Al Mahri, Mohammad Azhar Aziz, Shuja Shafi Malik and Sameer Mohammad*

Structural and Functional Aspects of Class A Carbapenemases

, 2016; 17(9): 1006 - 1028

Thierry Naas, Laurent Dortet and Bogdan I. Iorga

Targeted Thromboelastographic (TEG) Blood Component and Pharmacologic Hemostatic Therapy in Traumatic and Acquired Coagulopathy

, 2016; 17(8): 954 - 970

Mary K Bader, Francis J. Castellino, Victoria Ploplis, Faisal Shariff, Anton Crepinsek, Scott Thomas, Alyson Liew-Spilger, Sophia Binz, Jonathon McCollester, Mark Walsh, Adam Miller, Braxton Fritz, Swetha Chitta, Manar Jbara, Sarah Greve, Michael Son, Daniel Hake and Stephanie Fritz

Insights into a Critical Role of the FOXO3a-FOXM1 Axis in DNA Damage Response and Genotoxic Drug Resistance

, 2016; 17(2): 164 - 177

Gabriela Nestal de Moraes, Laura Bella, Stefania Zona, Matthew J. Burton and Eric W.-F. Lam

Most Cited Articles

Review Article

Celecoxib in cancer therapy and prevention - review

, 2019; 20(3): 302-315.

Natalia Tołoczko-Iwaniuk , Dorota Dziemiańczyk-Pakieła, Beata Klaudia Nowaszewska, Katarzyna Celińska-Janowicz and Wojciech Miltyk*

DOI: 10.2174/1389450119666180803121737

Review Article

Cyclin-dependent kinase 2 in cellular senescence and cancer. A structural and functional review

, 2019; 20(7): 716-726.

Priscylla Andrade Volkart, Gabriela Bitencourt-Ferreira, André Arigony Souto* and Walter Filgueira de Azevedo *

DOI: 10.2174/1389450120666181204165344

Review Article

High mobility group box-1 (HMGB1): A potential target in therapeutics

, 2019; 20(14): 1474-1485.

Eyaldeva C. Vijayakumar, Lokesh Kumar Bhatt* and Kedar S. Prabhavalkar

DOI: 10.2174/1389450120666190618125100

Review Article

A survey for predicting enzyme family classes using machine learning methods

, 2019; 20(5): 540-550.

Jiu-Xin Tan, Hao Lv, Fang Wang, Fu-Ying Dao, Wei Chen* and Hui Ding*

DOI: 10.2174/1389450119666181002143355

Review Article

Opportunities of bacterial cellulose to treat epithelial tissues

, 2019; 20(8): 808-822.

Irene Anton-Sales, Uwe Beekmann, Anna Laromaine*, Anna Roig* and Dana Kralisch

DOI: 10.2174/1389450120666181129092144

Review Article

Bioinformatics approaches for anti-cancer drug discovery

, 2020; 21(1): 3-17.

Kening Li, Yuxin Du, Lu Li and Dong-Qing Wei*

DOI: 10.2174/1389450120666190923162203

Review Article

CDK9 as an appealing target for therapeutic interventions

, 2019; 20(4): 453-464.

Shirin Eyvazi, Mohammad Saeid Hejazi, Homan Kahroba, Mozghan Abasi, Reza Eghdam Zamiri and Vahideh Tarhriz*

DOI: 10.2174/1389450119666181026152221

Review Article

Exosomes in therapy: Engineering, pharmacokinetics and future applications

, 2019; 20(1): 87-95.

Claudia Arenaccio, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Eleonora Olivetta and Maurizio Federico*

DOI: 10.2174/1389450119666180521100409

Review Article

Inhibition of RAGE axis signaling: A pharmacological challenge

, 2019; 20(3): 340-346.

Armando Rojas*, Miguel Morales, Ileana Gonzalez and Paulina Araya

DOI: 10.2174/1389450119666180820105956

Most Accessed Articles

Targeting Host Cell Proteases to Prevent SARS-CoV-2 Invasion

, 2021; 22(2): 192-201.

Kaur, Upinder; Chakrabarti, Sankha Shubhra; Ojha, Bisweswar; Pathak, Bhairav Kumar; Singh, Amit; Saso, Luciano; Chakrabarti, Sasanka

DOI: 10.2174/1389450121666200924113243

Downregulation of Membrane-bound Angiotensin Converting Enzyme 2 (ACE2) Receptor has a Pivotal Role in COVID-19 Immunopathology

, 2021; 22(3): 254-281.

Vieira, Cristina; Nery, Lucas; Martins, Ludimila; Jabour, Luiz; Dias, Raphael; Simoes e Silva, Ana Cristina

DOI: 10.2174/1389450121666201020154033

Physcion and Physcion 8-O-beta-D-glucopyranoside: Natural Anthraquinones with Potential Anticancer Activities

, 2021; 22(5): 488-504.

Adnan, Muhammad; Rasul, Azhar; Hussain, Ghulam; Shah, Muhammad Ajmal; Sarfraz, Iqra; Nageen, Bushra; Riaz, Ammara; Khalid, Rida; Asrar, Muhammad; Selamoglu, Zeliha; Adem, Sevki; Sarker, Satyajit D.

DOI: 10.2174/1389450121999201013154542

Curcumin and its Multi-target Function Against Pain and Inflammation: An Update of Pre-clinical Data

, 2021; 22(6): 656-671.

Uddin, Shaikh Jamal; Hasan, Md Fahim; Afroz, Mohasana; Sarker, Dipto Kumar; Rouf, Razina; Islam, Muhammad Torequl; Shilpi, Jamil A.; Mubarak, Mohammad S.

DOI: 10.2174/1389450121666200925150022

Nanotechnology Based Approach for Hepatocellular Carcinoma Targeting

, 2021; 22(7): 779-792.

Alhalmi, Abdulsalam; Beg, Sarwar; Kohli, Kanchan; Waris, Md; Singh, Tanuja

DOI: 10.2174/1389450121999201209194524

COVID-19 and Renal Diseases: An Update

, 2021; 22(1): 52-67.

Bitencourt, Leticia; Pedrosa, Ana Luisa; Camilo Soares de Brito, Stephanie Bruna; Fontoura Froes, Ana Claudia; de Carvalho, Sarah Tayna; Fonseca, Giulio Gori; Ferreira, Guilherme Costa; Fradico, Pollyanna Faria; Simoes e Silva, Ana Cristina

DOI: 10.2174/1389450121999201013151300

Targeting Drugs Against Fibroblast Growth Factor(s)-Induced Cell Signaling

, 2021; 22(2): 214-240.

Agrawal, Shilpi; Maity, Sanhita; AlRaawi, Zeina; Al-Ameer, Musaab; Kumar, Thallapuranam Krishnaswamy Suresh

DOI: 10.2174/1389450121999201012201926

Colorectal Cancer Epidemiology: Recent Trends and Impact on Outcomes

, 2021; 22(9): 998-1009.

Baidoun, Firas; Elshiwy, Kholoud; Elkeraie, Yasmine; Merjaneh, Zahi; Khoudari, George; Sarmini, Muhammad Talal; Gad, Mohamed; Al-Husseini, Muneer; Saad, Anas

DOI: 10.2174/1389450121999201117115717

Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression

, 2021; 22(2): 183-191.

Bhatt, Shvetank; Kanoujia, Jovita; Dhar, Arghya Kusum; Arumugam, Surendar; Silva, Amanda K. A.; Mishra, Neeraj

DOI: 10.2174/1389450121999201006193005


Francis J. Castellino
(16655 citations)
Dean Emeritus, College of Science,
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
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