Anti-infective agents are a distinct class of pharmacologically important molecules that has served mankind in different capacities to combat life-threating pathologic conditions. They include antibacterial, antifungal, antiviral, antituberculosis, antimalarial and urinary anti-infective agents. However, evolutionary changes, adaptations and development of pathogenic microorganisms strains the therapeutic efficacy of these drugs thus limiting their clinical utility over the years. Frontiers in Anti-Infective Agents Volume 5 is a collection of notable research efforts, successful anti-infective drug development programmes and a comprehensive overview of the successes and failures of recent clinical trials in this domain. The volume covers interesting topics: 1) the treatment of acute wounds with the vikut® formula, 2) anti-infective treatment of ocular diseases and 3) sars-cov vaccine development and antimicrobial therapy for SARS symptoms. A chapter summarizing recent anti-infective approaches rounds up the contents of this volume. This volume is a timely reference for postgraduate scholars and researchers seeking updates in specific areas of anti-infective drug development. Allied healthcare professionals (clinical and public healthcare professionals) can also benefit from the information presented within.

Scientific literature on SARS-COV-2 viruses and its variants (especially variants of concern such as the ‘Delta variant’) and important cellular targets is crucial to help researchers, epidemiologists, virologists and clinicians around the globe to develop a new generation of safer and more effective vaccines, and other treatments to address COVID-19 disease. The accompanying damage to the many organs and tissues of SARS-Co-2-infected people also needs to be understood and researchers are using data to devise meaningful protocols for treating these symptoms. This second volume of Coronaviruses brings together more useful information about the prevention, vaccination, and chemotherapies for the potential treatment of coronavirus infections. The volume includes eight chapters: (1) Broad spectrum antivirals to combat COVID-19 The reality and challenges, (2) COVID-19: Preventive and protective control management strategies, (3) Plant-derived extracts and bioactive compounds against coronavirus progression: preventive effects, mechanistic aspects, and structures, (4) Gastroenteritis: symptoms and epidemiology of SARS-CoV-2, (5) The chronicles of coronavirus: A Chinese king who conquered the entire world, (6) Traditional medicine as a natural remedy in ARDS & COVID-19, (7) Molecular pathogenesis of human coronaviruses of the 21st century, (8) COVID-19, mental health and neuropathophysiology of pain related to temporomandibular disorder. The volume serves as a novel compilation of key data on SARS-CoV-2 and COVID-19 and represents a resource of the utmost value for all scholars studying SARS-CoV infections. It should also be of great interest to clinicians who may be facing an overwhelming number of individuals affected with COVID-19, with over 267 million global cases documented as of the first week of December 2021).

Influenza is one of the most ancient and intriguing diseases that has been accompanying our civilization for millennia. While mankind has successfully defeated many dangerous influenza infections in the last couple of centuries, influenza control remains a serious problem for public health. A number of influenza vaccines and antiviral compounds have been licensed in recent times. However, the influenza virus is still ahead of us, as it continues to persistently infect humans to this day. Influenza: A Century of Research shows how influenza virology has developed historically and the tremendous knowledge that has been uncovered in the study of influenza. In this monograph, the authors present a historical perspective on influenza, chronologically, with an emphasis on its virology. Chapters cover information about the isolation of the first influenza viruses, substrates, and models for studying influenza, structure, and life cycle of the influenza virus, mechanisms of attenuation and virulence. Chapters progress into the multidisciplinary aspects of influenza research such as influenza virus ecology and the evolutionary origin of epidemic and pandemic influenza viruses. A significant part of the book also covers the description of the prevention and treatment of influenza and reasons that have contributed to insufficient control for influenza. The questions of how the COVID-19 pandemic affects the circulation of seasonal respiratory viruses, and if we can eliminate this virus are also addressed. Influenza: A Century of Research is an informative source of information for a broad range of readers, academic or otherwise, who are interested in knowing more about the disease.

Frontiers in Clinical Drug Research – Anti infectives is a book series that brings updated reviews to readers interested in learning about advances in the development of pharmaceutical agents for the treatment of infectious diseases. The scope of the book series covers a range of topics including the chemistry, pharmacology, molecular biology and biochemistry of natural and synthetic drugs employed in the treatment of infectious diseases. Reviews in this series also include research on multi drug resistance and pre-clinical / clinical findings on novel antibiotics, vaccines, antifungal agents and antitubercular agents. Frontiers in Clinical Drug Research – Anti infectives is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critically important information for developing clinical trials and devising research plans in the field of anti infective drug discovery and epidemiology. </p> The seventh volume of this series features these interesting reviews: </p> - Nucleic acid and peptide aptamers as potential antiviral drugs </p> - Host-directed, antibiotic-adjuvant combination, and antibiotic-antibiotic combinations for treating multidrug-resistant (mdr) gram-negative pathogens </p> - Bioactive substances as anti-infective strategies against clostridioides difficile </p> - Anti-toxoplasma drug discovery and natural products: a brief overview </p> - Development of antimalarial and antileishmanial drugs from amazonian biodiversity

The coronavirus disease 2019 (COVID-19) outbreak has spread throughout the globe and much time has passed since it was declared as a pandemic by the World Health Organization (WHO). COVID-19: Diagnosis and Management provides clinicians and scholars all the information on this disease in 2 volumes. Readers will find a concise and visual reference for this viral disease and will be equipped with the knowledge to assess and manage Sar-Cov-2 infection cases in clinical settings. </p> This book is divided into two parts (I and II). Part I provides comprehensive information about 1) History of Coronaviruses, 2) Epidemiology of COVID-19, 3) Clinical presentation of this viral disease and 4) COVID-19 diagnosis. Part II covers broader topics about this communicable disease including 1) the prevention and treatment methodology, 2) mortality and long-term complications, 3) COVID-19 vaccines and future perspectives. </p> Key Features: </p> Covers all the aspects of COVID-19 making this a perfect textbook for virology and medical students. </p> Chapter wise description and segregation of topics from pathophysiology to diagnosis and management of COVID-19. </p> Six chapters in the first part which focus on clinical basics of COVID-19. </p> Six chapters in the second part which cover broader topics for practical infection control. </p> Multiple tables and figures which summarize and highlight important points. </p> Presents a summary of the current standards for the evaluation and diagnosis of COVID-19. </p> Features a detailed list of references, abbreviations, and symbols. </p> This book is an essential textbook reference for medical students, scientists (virologists, pulmonologists) and public health officials who are required to understand COVDI-19 diagnosis and management as part of their clinical training or professional work.

The coronavirus disease 2019 (COVID-19) outbreak has spread throughout the globe and much time has passed since it was declared as a pandemic by the World Health Organization (WHO). COVID-19: Diagnosis and Management provides clinicians and scholars all the information on this disease in 2 volumes. Readers will find a concise and visual reference for this viral disease and will be equipped with the knowledge to assess and manage Sar-Cov-2 infection cases in clinical settings. </p> This book is divided into two parts (I and II). Part I provides comprehensive information about 1) History of Coronaviruses, 2) Epidemiology of COVID-19, 3) Clinical presentation of this viral disease and 4) COVID-19 diagnosis. Part II covers broader topics about this communicable disease including 1) the prevention and treatment methodology, 2) mortality and long-term complications, 3) COVID-19 vaccines and future perspectives. </p> Key Features: </p> Covers all the aspects of COVID-19 making this a perfect textbook for virology and medical students. </p> Chapter wise description and segregation of topics from pathophysiology to diagnosis and management of COVID-19. </p> Six chapters in the first part which focus on clinical basics of COVID-19. </p> Six chapters in the first part which cover broader topics for practical infection control. </p> Multiple tables and figures which summarize and highlight important points. </p> Presents a summary of the current standards for the evaluation and diagnosis of COVID-19. </p> Features a detailed list of references, abbreviations, and symbols. </p> This book is an essential textbook reference for medical students, scientists (virologists, pulmonologists) and public health officials who are required to understand COVDI-19 diagnosis and management as part of their clinical training or professional work.

This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discovery. The scope of the book series covers a range of topics including rational drug design and drug discovery, medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. Frontiers in Anti-Infective Drug Discovery is a valuable resource for pharmaceutical scientists and post-graduate students seeking updated and critically important information for developing clinical trials and devising research plans in this field. The ninth volume of this series features 5 reviews that cover some aspects of clinical and pre-clinical antimicrobial drug development, with 2 chapters focusing on drugs to treat leishmaniasis and dengue fever, respectively. - Use of preclinical and early clinical data for accelerating antimicrobial drug development - Post-translational modifications: host defence mechanism, pathogenic weapon, and emerged target of anti-infective drugs - Scope and limitations on the potent antimicrobial activities of hydrazone derivatives - Current scenario of anti-leishmanial drugs and treatment - Dengue hemorrhagic fever: the potential repurposing drugs

The management of COVID-19 is challenging due to the lack of clear information about the Sars-Cov2 and recommendations for specific treatment regimens. The scale of the pandemic has also exacerbated the situation, with health care systems under stress from the high volume of COVID-19 patients. In Demystifying COVID-19: Understanding the Disease, Its Diagnosis, and Treatment, medical experts explain many aspects about the COVID-19 pandemic, including guidelines to minimize risk of infection, diagnostic methods, treatment, real scenarios in the course of the disease and issues that need attention in specific patient groups. The book equips both general readers and healthcare professionals with key information required to understand COVID-19 and navigate a situation typical to a pandemic. Public health officials who wish to mobilize awareness campaigns for the benefit of the general public can also find value in the comprehensive information presented in this reference.

Histopathological Diagnosis of Leprosy, is a comprehensive guide to the medical pathology of Hansen’s disease, which is a complex and clinically challenging infection caused by Mycobacterium leprae. Readers will find 8 chapters on key topics on the subject including general aspects of leprosy, different forms of leprosy (polar, borderline, etc.), reaction types and complications. The information presented in the handbook will equip the reader with the knowledge required to identify the disease in patients and perform differential diagnosis where required. Key Features: - 8 chapters dedicated to key topics about leprosy and its diagnosis - More than 2014 figures featuring over 1000 clinical and histopathological photographs - Complete information about differential diagnosis and reaction phenomena - includes a section dedicated to special and complicated cases - References for further reading - Brings the expertise of renowned physicians to the reader The detailed presentation of the book is of great value to both healthcare professionals (pathologists, dermatologists, physicians) who are involved in the care of leprosy patients, and medical residents who are seeking information about the disease as part of their medical training.

This reference comprehensively covers the clinical aspects of head and neck neoplasms while also highlighting the relationship that exists between inflammation and these cancers. This relationship is critical as it dictates the risks, assessment, treatment, and prognosis of head and neck cancer patients. The book starts with an introduction to the inflammation ecosystem in head and neck malignancy, followed by detailed discussions on the types of head and neck malignancy and their histological classification. The book then provides information about specialized topics relevant to the specialty of head and neck oncology. Key Features: - Comprehensive coverage of head and neck cancers with topic-based chapters - Introductory text explaining the basics of inflammation - Detailed information on the relationship between inflammation and head and neck neoplasms - Information about the classification of head and neck cancers - Methods for diagnosis and treatment - Special topics such as complications caused by HPV infections, chemoradiation, immune-targeted therapy, and inflammatory biomarkers - References for further reading The combination of basic and advanced topics makes this book an informative reference for medical students and professionals at all levels. Residents specializing in otolaryngology, oncology, and surgery as well as researchers studying inflammation will also gain an understanding of the subject in relation to oncogenesis.