Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is globally afflicting an estimated 36 million people and this number is growing in an unabated and frightening manner. Advances in Alzheimer Research, provides researchers with an integrated approach to AD academic literature ranging from basic to advanced clinical research. The series highlights the latest information in order to unravel the origin, pathogenesis and prevention of AD. The purpose of this book series is, therefore, to capture and discuss both, improvements towards the diagnosis and potential treatment of AD by established and novel strategies. This first volume of the series provides an important mechanism to bring individuals having a variety of scientific interests and expertise under one roof to specifically focus on AD and related dementias. This volume presents articles on beta amyloid protein targets as well as research on secretase enzyme systems among other topics that deal with AD therapy.

Alzheimer’s disease (AD) is currently recognized as an untreatable, progressive, degenerative and terminal disease that is global – afflicting over 36 million people worldwide, with the number growing in an unabated and frightening manner. The goal of the series Advances in Alzheimer’s Research , with Volumes 1 and 2, is to provide an integrated approach to AD from basic and clinical research and to highlight the valuable information in order to unravel the origin, pathogenesis and prevention of AD. The aim of this book is to both capture and discuss improvements toward the diagnosis and potential treatment of AD by both established and novel strategies. This book series, including the Volume 2, provides an important mechanism to bring under the same roof a variety of scientific interests and expertise to specifically focus on AD and related dementias. The fullest attempt has been made to disseminate the most current knowledge on recent advances in potential therapy of AD.

Stem cells with self-renewal and multi-lineage differentiation potential have potential for developing medicines for a range of refractory and recurrent disease. This book mainly focuses on the landscape of the biological properties and translational research of stem cells types, including hematopoietic stem cells (HSCs), neural stem cells (NSCs) and mesenchymal stem/stromal cells (MSCs). The book also introduces readers to the current updates and development prospects of stem cells in singular or combination therapies with advanced biomaterials and technological innovations towards large-scale standardization and productization. Key Features: - Introduces readers to stem cell biology and tissue engineering - Covers innovations in stem cell therapy and biomaterials - Includes a brief guide to commercialization of stem cell technology - Includes references for advanced readers The contents will strengthen the reader’s understanding of stem cell-based therapies. This book is a primer on stem cell and regenerative medicine for a wide readership including students, healthcare professionals, researchers and general readers.

Contemporary Endoscopic Spine Surgery brings the reader the most up-to-date information on the endoscopy of the spine. Key opinion leaders from around the world have come together to present the clinical evidence behind their competitive endoscopic spinal surgery protocols. Chapters in the series cover a range of aspects of spine surgery including spinal pain generators, preoperative workup with modern independent predictors of favorable clinical outcomes with endoscopy, anesthesia in an outpatient setting, management of complications, and a fresh look at technology advances in a historical context. The reader will have a first-row seat during the illustrative discussions of expanded surgical indications from herniated disc to more complex clinical problems, including stenosis, instability, and deformity in patients with advanced degenerative disease of the human spine. Contemporary Endoscopic Spine Surgery is divided into three volumes: Cervical Spine, Lumbar Spine, and Advanced Technologies to capture an accurate snapshot in time of this fast-moving field. It is intended as a comprehensive go-to reference text for surgeons in graduate residency and postgraduate fellowship training programs and for practicing spine surgeons interested in looking for the scientific foundation for their practice expansion into endoscopic surgery. This volume (Lumbar Spine) covers the following topics in 18 detailed chapters: Lumbar endoscopy: historical perspectives, present, and future Endoscopic lumbar discectomy - anatomy, nomenclature, indications and advanced techniques Current approaches for the treatment of endstage vacuum degenerative lumbar disc disease Advanced endoscopic techniques of lumbar foraminotomy and treatment of degenerative spondylolisthesis Endoscopic treatment of lumbar facet cysts Endoscopic techniques for the treatment of a wide range of chronic low back pain Endoscopic spine surgery techniques in the elderly Endoscopic fusion techniques Endoscopic resection of schwannoma Technical notes for difficult cases, controversies and complications of lumbar endoscopy.

Nanomedicine is evolving with novel drug formulations devised for multifunctional approaches towards diagnostics ad therapeutics. Nanomedicine-based drug therapy is normally explored at a fixed dose. The drug action is time-dependent, dose-dependent and patient-specific. To overcome challenges of nanomedicine testing, artificial intelligence (AI) serves as a helping tool for optimizing the drug and dose parameters. Real time conversions between these two features enables upgradation of patient data acquisition and improved design of nanomaterials. In this scenario, AI-based pattern analysis and algorithms models can greatly improve accuracy of diagnostics and therapeutics. This book gives a comprehensive explanation of the role of machine learning and artificial intelligence in cancer nanomedicine. It presents 10 chapters that cover multiple dimensions of the subject. These dimensions are: - The need of AI and ML in designing new cancer drugs - Application of AI in cancer drug design - AI-based drug delivery models for cancer drugs - Diagnostic applications of AI - Intelligent nanosensors for biomarker profiling - Predictive models for metastatic cancer - Cancer nanotheranostics - Ethics of AI in medicine Contributions have been made by 16 researchers who are experts in pharmacology and drug design. The contents of the book bridge knowledge gaps between the fields of biomedical engineering, pharmacology and clinical medicine, with a focus on cancer treatment. The book serves as a reference for scholars learning about cancer diagnostics and therapeutics. Biomedical engineers who are involved in healthcare projects will also find the concepts and techniques highlighted in the book informative for understanding modern computer-based approaches used to solve clinical problems.

Colorectal Cancer is a complex disease caused by the interaction of hereditary and environmental factors that can be classified based on their importance. Colorectal Cancer Diagnosis and Therapeutic Updates provides comprehensive information about the diagnosis and treatment of colorectal cancer. Chapters first cover the fundamentals of colorectal cancer diagnosis, progressing further towards explaining therapeutic modalities and recent advances in the understanding of the disease. Key Features - 11 organized, reader-friendly chapters that provide a complete overview of colorectal cancer - Covers the colorectal cancer diagnosis, screening and histopathology - Covers multimodal treatment of colorectal cancer, including chemotherapy, radiotherapy and robotic surgery - Covers the management and surveillance of colorectal cancer - Explains the key biochemical mechanisms involved in colorectal cancer treatment - Covers recent information about colorectal cancer theranostics and drug delivery - Includes references for further reading in every chapter. The book serves as an introductory reference for medical students and residents on the subject of colorectal cancer. It also serves as a quick reference on the disease for the practicing general physician.

Diabesity refers to the linkage of both diabetes and obesity that results in the coexistence of these 2 conditions. Research has identified pathophysiological mechanisms revolving around insulin resistance and hyperinsulinemia. Diabesity has important diagnostic and therapeutic implications. This book is a multidisciplinary review of diabesity. It highlights the various pharmacological methods of managing the condition. The book presents 10 chapters contributed by more than 40 experts from around the world. The review starts with an overview of diabesity and progressively describes the relationships of diabesity with the choice of diets and psychological factors. The chapters then cover the role of adipokines as therapeutic biomarkers before presenting research on medicinal and nutritional approaches to treat the condition. Modern approaches to diabesity treatment such as the use of new bioactive phytochemicals, mitigating meta-inflammation and laboratory techniques are also reviewed in the book. Diabesity: A Multidisciplinary Approach is a timely reference for clinicians (in endocrinology and family medicine subspecialties) and students of pharmacology and medicinal chemistry on the intricate relationship between diabetes and obesity.

Advances in biochemistry, molecular biology, virology, and structural biology have enabled the researchers in veterinary medicine to make many exciting discoveries that have, in some cases, conceptually revolutionized our understanding of the discipline. Emerging Trends in Veterinary Virology is a review of selected topics about viral infections in animals. 11 chapters cover recent findings about specific viruses that infect a variety of hosts. The contents cover several types of veterinary infections in birds (Infectious laryngotracheitis (ILT), avian leucosis), cats (feline rabies), dogs (canine distemper), bovines (viral leukemia) and equines (hendra virus disease). Additionally, special topics such as the epidemiology of veterinary zoonoses and SARS are also covered. The book provides updated information for researchers (virologists, microbiologists), students and veterinarians, alike.

Systemic lupus erythematosus (SLE) is an autoimmune disease. SLE affects many parts of the body, with joint pain in the knees and hands being commonly reported symptoms. Arthritis is, therefore, one of the most common symptoms of the disease. This book comprehensively summarizes information about SLE for medical professionals and students. The volume illustrates the process of making accurate diagnoses through systematic interpretation of ABCDEGFGI parameters: A (Alignment): malalignment and deformation; B (Bone): bone changes; C (Capsular lesions): cartilage and intra-articular lesions; D (Distribution): four dimensional distributions; E (Extra-bone): extra-articular soft tissue; F (Further information): further additional medical information; G (Goal): general analysis and integrated comprehensive diagnosis; H (Heal and Heath): treatment and prognosis; and I (Immunological analysis): immunological interpretations. Key Features: - Presents information about the clinical features of SLE and differential diagnosis through 11 chapters - Covers both rheumatic symptoms and systemic symptoms - Provides a comprehensive approach to SLE diagnosis and management which blends both rheumatology and radiology - Explains the ABCDEFGI system for diagnosing and treating SLE patients - Includes more than 750 detailed figures illustrating important information - Includes references for further reading The book is an informative resource for a wide range of scholarly and professional readers who may encounter SLE patients in clinical settings: rheumatologists, orthopedists, radiologists, physiatrists, immunologists, pediatricians, general physicians, medical technicians, caregivers and specialists in internal medicine.

Pediatric Anesthesia: A Guide for the Non-Pediatric Anesthesia is a comprehensive, contemporary reference that addresses all aspects of pediatric anesthesia. Both students and medical practitioners - novice and experienced - will find invaluable educational and practical information in this book. The book covers the subject in two parts. Part I covers basic information about pediatric and neonatal anatomy and physiology, pharmacology, emergency room and operating room procedures and surgery. Chapters on general anesthetic procedures in emergency rooms, operational theatres and common surgeries. Part II covers advanced topics for practicing healthcare professionals which include anesthesia for patients with a range of common and uncommon comorbidities, considerations for critically-ill patients, genetic disorders, pain management, COVID-19 guidelines for anesthesia, patient safety and research. Key features: - Basic and advanced information about pediatric and neonatal anesthesia covered in 25 chapters over two parts - Simple and organized presentation for learners - Contributions by expert clinicians and researchers - Special topics included such as considerations for patients with comorbidities and genetic disorders - References for further reading - Detailed illustrations and tables The text is an essential reference for scholars and professionals affiliated with general anesthesiology and surgery specialties at all levels who want to understand anesthesia for pediatric patients.