Pain is the most prevalent form of human health malady which, if remain
unaddressed, exerts formidable impact. Pain research has tried hard to unravel the
possibilities in the direction of diagnosis and management of pain conditions, but
knowledge of genetic consequences of pain is still in infancy. During pain, sensory
input is realized, processed and regulated, first and foremost through ones genetic
composition and then different characters of physiology, psychology, sociology and
environment come in the scene. The present exposition demonstrates the precise details
of various genes and genetic variants that participate in different phases of pain and
pain conditions, disseminating an idea that in future, diagnosis and treatment of pain by
harnessing indepth genetic knowledge has startling revelations in store for us.
Keywords: Chronic pain, Conduction, Genes, Modulation, Synaptic transmission,
Transduction.
