The invention and administration of novel antiretroviral therapies (ART) has led to the increased lifespan of People Living with HIV (PLHIV) especially in the developed world and thus, we are facing with increased number of HIV infected people over the age of 50 years. It seems that HIV infection may accelerate the aging process by accelerating the shortening of telomeres. Several adverse habits such as smoking and drug abuse as well as co-infection with other pathogens are more common among PLHIV. So, by increasing the age, inappropriate lifestyle and adverse habits such as cigarette smoking, drinking a lot of coffee, being physically inactive or inappropriate activity, opium and drug abuse and alcoholism put people in higher risk of osteoporosis. Several issues should be considered about aging like osteoporosis, neurocognitive impairment, cardiovascular disorders, and impairment of liver function along with the especial consideration about ART in elderly. There are several recommendations for slowing down the aging process in PLHIV. The cessation of cigarette smoking is the main step to prevent undesirable complications such as lung diseases and cancer, increased risk of heart attacks and strokes, bone mineral loss, muscle wasting and memory disorders. Drug abuse, especially some newer drugs like amphetamines and “crystal” may lead to several memory and behavioral impairment, depression and suicide. Regular exercise is another health habit that should be promoted among older PLHIV.