HIV spread in many developing countries is high as a result of homosexual, heterosexual intercourses and drug abusing. Most HIV infected individuals are attributable to heterosexual intercourse. There are several biologic and behavioral risk factors lead switching a discordant couple to concordant one such as having a high HIV viral load, living together, being uncircumcised for men, and reporting a Sexually Transmitted Disease (STD) within the six months before the beginning of consensual sex intercourse for women. Strategies on prevention includes the use of condom, abstinence and bed separation, contractual agreements for outside sexual partners, and cessation of relationships for any couple, providing early sexually transmitted disease diagnosis and treatment, antiretroviral therapy (ART), and specially designed counseling to HIV discordant couples in stable relationship. ART can protect against the HIV transmission from an infected sexual partner to an uninfected one by reducing viral replication.