A multi-target strategies targeting on various biochemical and physiological
pathways implicated in tumour pathogenesis should be developed with the ultimate aim
to manage patients with cancer and reduce the normal-tissue toxicity. Tumor
angiogenesis has been recently discovered as an important strategy in treating cancer as
most tumors rely on angiogenesis to survive, develop, invade and metastasize.
Targeting angiogenesis to inhibit the progression of tumorigenesis has recently been a
focus in developing novel anti-cancer development. This is mainly due to the
specificity that anti-angiogenic possesses: it targets on newly-formed blood vessels and
spares the existing ones. With that being said, inhibiting angiogenesis is now
considered a promising strategy in the development and selection of new anti-cancer
drug candidates. To date, there are cytotoxic drugs which also exhibit antiangiogenic
activity but not angiogenesis inhibitors in whole. In this chapter, we will be discussing
selected natural sources including marine products which have been investigated for
their antiangiogenic activities. Various methods in validating the effects as well as their
possible multiple pathways will also be contended in this chapter.
Keywords: Angiogenesis, Antiangiogenic, Cancer development, Marine
products, Phytochemicals.
