• The dogma “there is no role for the surgical treatment of liver metastases from non-colorectal non-neuroendocrine tumors” is no longer valid.
• There are no guidelines for the management of non-colorectal non-neuroendocrine liver metastases and the complex decision management should be done by a multidisciplinary tumor board.
• The variety of clinical situations, like individual tumor site and histology, patient age, disease-free interval between treatment of the primary tumor and diagnosis of the metastases, intrahepatic tumor burden, response to chemotherapy, and the presence of extrahepatic disease should be considered in the surgical management of non-colorectal non-neuroendocrine liver metastases.
• In general, liver resection of non-colorectal non-neuroendocrine liver metastases should be considered in patients with well-controlled disease or responding to chemotherapy.
• Hepatic resection of non-colorectal non-neuroendocrine liver metastases is a safe,feasible, and effective treatment.
• Selected patients with non-colorectal non-neuroendocrine liver metastases can have similar survival to their colorectal cancer counterparts.
