Mesothelioma is a rare tumor that derives from the mesothelial cells lining of
body cavities. About 90-95% of mesotheliomas originate in the pleura and 5-10% in the
peritoneal space. Other sites, such as pericardium and tunica vaginalis are very rare.
Generally, mesotheliomas disseminate locally and tend to coat the organs in the
different body cavities. The aim of this chapter is to describe the histological,
histochemical, and immunohistochemical features of pleural mesotheliomas.
Keywords: Calretinin, CEA, histochemistry, immunohistochemistry.
