Bacteriophages are viral, natural and bacterio-specific entities. As a major
part of the biosphere, they were involved in the origin of life. They still play an
essential role in evolution and are highly involved in the development of molecular
biology. In the issued biotechnology industry, they are promising as a sustainable
antibacterial. Felix d’Hérelle, one of the discoverers of bacteriophages, first proposed
“(bacterio) phage therapy” in the early 20th century. At the Eliava Institute in Tbilisi,
Georgia it was further developed and it is still used in medical practice in all the former
Soviet Republics. The Western world, with the advent of antibiotics, almost forgot
phage therapy.
The antibiotic resistance crisis placed phage therapy again in the spotlights. The main
problem today is the lack of evidence based therapeutic phage studies in accordance to
modern standards as well as the lack of an adapted phage therapy regulatory frame.
Initiating clinical studies in this context is difficult. Phage therapy is sporadically
applied today, although under specific conditions like the Helsinki Declaration and/or
specific national regulatory frames (Poland). This impedes clinical application and
scientific progress.
However, several groups setup animal and human studies, while the idea of using
bacteriophages as antibacterial is already applied in the food industry. In the clinic
application seems imminent. Several issues, also from the fundamental scientific
perspective, still need to be tackled while practically an adapted regulatory frame is
urgently needed.
Keywords: Antibiotic crisis, Antibiotic resistance, Bacterial host, Bacteriophage,
Diarrhoeal diseases, Eliava Institute, Escherichia coli, Food and Drug
Administration, Holins, hormesis, Listeria monocytogenes, Phage cocktail,
Pharmaceutical industry, Pseudomonas aeruginosa, Public health, Regulatory
obstacles, Safety, Seed lots, Staphylococcus aureus, Therapy.
