Oxadiazine scaffold-based compounds are undoubtedly an important class of
heterocyclic derivatives, which always present diverse bioactivities including
cardiovascular, antitumor, antiviral, anti-leishmanial, antibacterial, antimicrobial,
monoamine oxidase inhibition, acricidal, insecticidal, plant-growth regulating activities
and chitin biosynthesis inhibitions. With the development of organic synthesis, versatile
features of oxadiazine ring have emerged, so here we have reviewed the recent
advances of oxadiazine-based heterocyclic derivatives mainly including preparation,
transformation and biological properties, and this report is also an updated version of
our previous review with modifications.
Keywords: Oxadiazine, oxadiazinone, heterocyclic scaffold, synthetic method,
pharmaceutical activity, pesticidal activity, biological application.
