Pharmacogenomics is considered to be the extension of the rapidly growing
field of pharmacogenetics. Its aim is to determine the genetic roles for inter-individual
variations in drug response. It has been applied to various existing chemotherapy
treatments in an attempt to detect genetic factors that play a significant role in optimal
chemotherapy drug selection, dosage, and duration of use. In addition,
pharmacogenomics studies aim to clarify, predict, and detect safety, toxicity, and/or
efficacy of chemotherapy. Moreover, it can be used in predict patients’ response to
chemotherapy and to personalize chemotherapy treatment, thereby tailoring a patient’s
treatment strategy on the basis of his or her genetic map. Therefore, pharmacogenomics
will significantly improve the work of researchers, pharmacists, and physicians working
on the discovery, synthesis, and development of novel chemotherapeutic treatments that
depend on pharmacogenomic science and/or techniques.
Keywords: Cancer, cancer pharmacogenomics, chemotherapy, hematological
tumors, personalizing chemotherapy treatment, pharmacogenetics, pharmacogenomics,
solid tumors.
