Towards the eventual goal of translating the cancer inhibitory effect of
inositol & InsP6 seen in experimental animals in vivo to cancer prevention and therapy
in humans, studies of human cancer cells lines were performed in vitro; and human
cancer cells xenotransplanted in nude mice were used to test the therapeutic potential. A
consistent and reproducible broad-spectrum anticancer action of InsP6 ± inositol was
observed in various models; in human breast cancer model InsP6 showed synergism
with standard chemotherapeutic agents Adriamycin or Tamoxifen. Suppression of
cancer growth was seen in xenotransplanted rhabdomyosarcoma model and regression
of preexisting cancer was seen in hepatoma model. InsP6 ± inositol also inhibited
various steps in cancer metastasis, inositol potentiated the action. These findings are
compelling reasons for application of InsP6+inositol for human cancer control.
Keywords: Adriamycin, CEA, chemotherapeutic agent, collagen, fibronectin,
haptotactic migration, HepG2, hepatoma, hepatocellular carcinoma, laminin,
MCF-7, MDA MB 231, metastasis, MMP, nude mice, Tamoxifen, TRAMP,
synergism, xenotransplantation.