Obesity is a global epidemic and one of the major health burdens of modern
times. The prevalence of obesity is increasing worldwide; it constitutes a serious
problem in developed as well as developing countries. Beside adults, the number of
obese teenagers and children in particular has dramatically increased. Obesity is
characterized by accumulation of excess fat in adipose tissues in an extent to produce
adverse effects on health, leading to a reduction in life expectancy and/or a raise in
health hazards. People are classified as overweight (pre-obese) and obese on the basis of
the Body Mass Index (BMI), crude measure which compares weight to height. Obesity
is usually associated with and can lead to many disease conditions, mainly type-2
diabetes, cardiac diseases, hypertension, sleep apnea, cerebrovascular incidents,
osteoarthritis and certain types of cancers. The tremendously increasing number of
reviews on the subject of obesity obviously reflects the amount of investigations
currently dedicated to this field. The core of obesity treatment is dieting and physical
exercise. The consumption of energy-dense food is reduced versus an increase in that of
dietary fibers. Conventional medication relies mainly on drugs which either reduce
appetite or inhibit fat absorption. However, drug treatment of obesity despite short-term
benefits, is often associated with undesirable harmful side effects, rebound weight gain
after discontinuation of drug intake, and the incidence of drug abuse. If diet, exercise
and pharmacological therapy are ineffective; surgical intervention may be useful. The
anti-obesity potential of natural products if accurately explored might provide an
excellent alternative strategy for the scientifically-based development of safe and
effective drugs. Especially that, they are actually widespread for this purpose as
nutritional supplements. OTC anti-obesity natural products are mostly complex in terms
of chemical composition and may exert a variety of pharmacological actions leading to
weight loss. These include: inhibition of lipases activity, suppression of appetite,
stimulation of energy expenditure, inhibition of adipocyte differentiation and regulation
of lipid metabolism. A variety of natural products, including crude extracts and isolated
compounds induce body weight reduction and prevent diet-induced obesity. Examples
of these constituents are polyphenols, triterpenoidal and steroidal saponins, pregnane
glycosides, alkaloids, abietane diterpenes and carotenoids amongst others. In addition, a
number of lipase inhibitors are obtained from microbial sources.
The present chapter is intended to survey the vast array of natural products from plant
and microbial origin currently suggested as conventional drug alternatives for
management of obesity. This will cover the natural sources, extracts, safety assessment
and structures of bioactive compounds, as well as the biochemical markers used to
evaluate the anti-obese effect and/or determine the mechanism of action. New drug
targets that may play a role in the regulation of body weight will also be considered.
Keywords: Anti-obesity, herbal medicine, micro-organisms, mechanisms, natural
products, phytochemicals, plants.
