Rho GTPases, which control processes such as cell proliferation and
cytoskeleton remodeling, are often hyperexpressed in tumors. Several members, such as
RhoA/B/C, must be isoprenylated to interact with their effectors. Statins, by inhibiting
the synthesis of prenyl groups, may affect RhoA/B/C activity and represent a promising
tool in anticancer therapy.
Keywords: Cancer, chemotherapy, isoprenylation, rho GTPases, statins.
