Multiple myeloma (MM) is a complex disease which strongly relies on a network of humoral
and cellular interactions within the human bone marrow milieu. Although outcomes of anti-MM
treatments have improved over the past decade, the disease is still incurable. Translational research for
the development of novel therapeutic approaches against MM requires experimental preclinical models
able to recapitulate the disease microenvironment. Over the last few years, a variety of murine MM
models have been developed. These models have significantly improved our understanding of the
disease and led to the development of new therapeutics. We here review the most known models of
MM and discuss both advantages and pitfalls.
Keywords: Xenograft mouse models, diffuse xenograft mouse models, SCID mouse, SCID-hu mouse,
SCID rab mouse, NOD/SCID mouse, 5TMM, VK* myc, LAG-1 model.
