Thyroid Cancer: A Clinical Overview and A Useful Laboratory Manual

Tyrosine Kinase Inhibitor and Target Therapy

Author(s): Brilli Lucia

Pp: 85-95 (11)

DOI: 10.2174/9781608057498113010011

* (Excluding Mailing and Handling)


“Tyrosine kinase inhibitors” (TKI) are small molecules responsible for selectively inhibiting cellular pathways involved in cell proliferation or migration. These molecules have been developed as alternative therapy for refractory or minimal responsive cancers to standard treatments. In this chapter, TKI currently used for anaplastic thyroid cancer, medullary thyroid cancer and/or refractory differentiated thyroid cancer will be described.

Keywords: Tyrosine kinase, Tyrosine Kinase Inhibitors (TKI), growth factor receptors.

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