Thyroid Cancer: A Clinical Overview and A Useful Laboratory Manual

Alternative Methods for the Diagnosis of Thyroid Nodules

Author(s): Paolo E. Macchia

Pp: 15-24 (10)

DOI: 10.2174/9781608057498113010006

* (Excluding Mailing and Handling)


Thyroid nodules can be identified in approximately 5% of the population. The American Thyroid Association guidelines indicate fine needle aspiration as the most accurate method for the evaluation of a thyroid nodule; however in up to 20% of cases, cytology produces indeterminate or suspicious results that require surgery to complete the diagnosis. This chapter reviews molecular markers, which can be detected using protein-based assays, to improve the sensitivity of FNA.

Keywords: Galectin-3, HBME-1, CK-19, CD44v6, HMGI(Y), TPO.

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