The unique feature of photonic crystal fiber (PCF) both as a light guide and a gas/liquid
transmission cell allows synergistic integration of optics and microfluidics. There is a growing interest in
PCF as a platform for spectroscopy-based chemical and biological sensing. In this chapter, we focus on PCF
for sensing and detection using surface-enhanced Raman scattering (SERS). We examine the state-of-theart,
challenges and opportunities in the development of SERS-active PCF sensors.
Keywords: Photonic crystal fiber, surface-enhanced raman scattering, chemical sensing.
