The Amaranthaceae family comprises of many species, which are used in nutrition and in
traditional folk medicine for the treatment of several diseases such as infections, inflammation and
fever. Gomphrena, Pfaffia and Alternanthera species are used in the extraction of natural pigments such
as betaxanthin and betalains for application as food colorants and antioxidants. Pfaffia paniculata
(Brazilian ginseng or Suma) has been indicated as a tonic, as well as having aphrodisiac, analgesic, and
antidiabetic properties and may act against cancer. Gomphreneae is the major tribe of Amaranthaceae
and previous chemical analyses have demonstrated the occurrence of anthraquinones, aurone,
betacyanins, betaxanthins, betalains, chromoalkaloids, ecdysteroids, flavonoids, protoalkaloids,
saponins, steroids and triterpenes. Biotechnological investigation with Amaranthaceae plants from the
Gomphreneae tribe, demonstrated their potential for bioprospection of bioactive natural compounds
such as flavonoids, steroids, terpenoides and saponins. Plant cell cultures, nowadays, are an important
strategy for bioprospection of natural products. The in vitro large-scale production of bioactive
compounds or extracts used as phytotherapics, pharmaceutical products, food additives and cosmetics
should be encouraged because of their scientific, economical or ecological importance. Therefore, the
present chapter reviews the literature data of the bioactive chemical constituents and biotechnological
production of secondary metabolites in Amaranthaceae plants (Gomphreneae tribe), species that have
many pharmacological properties and other applications.
Keywords: Traditional folk medicine, Amaranthaceae, Gomphrena, Pfaffia, Alternanthera, secondary
metabolites, biological activity, biotechnological production, chemical diversity, chemical composition,
saponin, triterpen, flavonoid.
