Recycling of endocytic cargoes utilizes multiple pathways employing Rab small GTPases. Rab11a is associated with slow recycling pathways that are responsible for plasma membrane recycling in non-polarized cells and the apical recycling system in polarized cells. Rab11a assembles multiple protein complexes along the recycling pathway utilizing multiple Rab11-Family Interacting Proteins and Class V myosins. Rab8a also assembles regulatory complexes associated with recycling pathways. While myosin V species are involved in both Rab11a- and Rab8a-dependent pathways, the details of interactions between these trafficking pathways remains unclear.
Keywords: Rab11, Rab8, Myosin V, Rab11-FIP, Vesicle Trafficking.