Angiogenesis plays a pivotal role in progression of both solid and hematologic
tumors. We have focused on multiple myeloma (MM) and its bone marrow stromal cells which
are not only a support for tumor cell survival, but also active inducers of angiogenesis by
releasing a broad number of angiogenic cytokines. Also, stromal cells such as macrophages and
mast cells can participate in blood vessels formation in MM through other processes, such as a
vasculogenic mimicry. Finally, it has been discovered that hematopoietic stem and progenitor
cells (HSPCs) are involved in the vasculogenesis of MM.
